Measurement of RBC deformation and velocity in capillaries in vivo

Jeong, Jooyeon; Sugii, Yasuhiko; Minamiyama, Motomu; Okamoto, Koji

doi:10.1016/j.mvr.2006.02.006

Cited by 87 publications

(68 citation statements)

References 11 publications

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“…Stress can lead to biological and biochemical consequences in cells, such as cell deformation, differentiation, and even cell death. 35,36 Simulation will help select proper experimental conditions (fluid pressure, velocity, trap material, etc.) that avoid undesired damage of the fragile particles.…”

Section: -11mentioning

confidence: 99%

Finite element simulations of hydrodynamic trapping in microfluidic particle-trap array systems

Nehorai

2013

Biomicrofluidics

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Computational fluid dynamic (CFD) simulation is a powerful tool in the design and implementation of microfluidic systems, especially for systems that involve hydrodynamic behavior of objects such as functionalized microspheres, biological cells, or biopolymers in complex structures. In this work, we investigate hydrodynamic trapping of microspheres in a novel microfluidic particle-trap array device by finite element simulations. The accuracy of the time-dependent simulation of a microsphere's motion towards the traps is validated by our experimental results. Based on the simulation, we study the fluid velocity field, pressure field, and force and stress on the microsphere in the device. We further explore the trap array's geometric parameters and critical fluid velocity, which affect the microsphere's hydrodynamic trapping. The information is valuable for designing microfluidic devices and guiding experimental operation. Besides, we provide guidelines on the simulation set-up and release an openly available implementation of our simulation in one of the popular FEM softwares, COMSOL Multiphysics. Researchers may tailor the model to simulate similar microfluidic systems that may accommodate a variety of structured particles. Therefore, the simulation will be of particular interest to biomedical research involving cell or bead transport and migration, blood flow within microvessels, and drug delivery.

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Section: -11mentioning

confidence: 99%

Finite element simulations of hydrodynamic trapping in microfluidic particle-trap array systems

Nehorai

2013

Biomicrofluidics

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“…The perfusion of blood via capillary bed is regulated by physical laws. We can quantify neither the details of myogenic tonus of arterioles, nor the transmural pressure within capillaries [5][6][7].…”

Section: The Role Of Microcirculationmentioning

confidence: 99%

Harmful or Helpful Hypertension – Pathophysiological Basis

Budaj¹,

Hulín²

2012

Genetics and Pathophysiology of Essential Hypertension

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“…To calibrate the model, data were extracted from the experimental work of Hong Jeong et al [18], which indicated RBC deformation index DI = 1.55 and velocity V = 1.8 mm/s inside the capillary of a rat mesentery. Assuming that blood density at normal temperature is = 1.05 g/cm 3 as was stated by Nakano and Sugii [19] and that the velocity of the RBCs is representative of the average blood velocity in the capillary, then the estimated blood viscosity is = 2.35 cP and the average Reynolds number is Re ≈ 0.0055 for a random capillary size.…”

Section: Surface Tension Effects On a Single File Flow Rbcs Shape Andmentioning

confidence: 99%

A multi‐component lattice Boltzmann model with non‐uniform interfacial tension module for the study of blood flow in the microvasculature

Farhat¹,

Lee²,

Lee³

2011

Numerical Methods in Fluids

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SUMMARYThis study aims at analyzing the red blood cell (RBC) deformation and velocity while streaming through venules and through capillaries whose diameters are smaller than the RBC size. The characteristics of the RBC shape change and velocity can potentially help in diagnosing diseases. In this work, the RBC is considered as a surfactant-covered droplet. This is justified by the fact that the cell membrane liquefies under pressure in the capillaries, and this allows the marginalization of its mechanical properties. The RBC membrane is in fact a macro-colloid containing lipid surfactant. When liquefied, it can be considered as a droplet of immiscible hemoglobin covered with lipid surfactant in a plasma surrounding. The local gradient in the surface tension due to non-uniform local interface surfactant distribution is neglected here, and a non-uniform zonal-averaged value of surface tension representative of the surfactant bulk zonal concentration is rather implemented. The interplay between the surface tension geometry and the hydrodynamic conditions determines the droplet shape by affecting a change in its Weber number, and influences its velocity. The Gunstensen lattice Boltzmann model for immiscible fluids is used here since it provides independent adjustment of the local surface tension, and allows the use of fluids with viscosity contrast. The proposed concept was used to investigate the dynamic shape change of the RBC while flowing through the microvasculature, and to explore the Fahraeus and the Fahraeus-Lindqvist effects.

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Measurement of RBC deformation and velocity in capillaries in vivo

Cited by 87 publications

References 11 publications

Finite element simulations of hydrodynamic trapping in microfluidic particle-trap array systems

Finite element simulations of hydrodynamic trapping in microfluidic particle-trap array systems

Harmful or Helpful Hypertension – Pathophysiological Basis

A multi‐component lattice Boltzmann model with non‐uniform interfacial tension module for the study of blood flow in the microvasculature

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