Measurement of Quantitative Viscoelasticity of Bovine Corneas Based on Lamb Wave Dispersion Properties

Zhang, Xinyu; Yin, Yin; Guo, Yanrong; Fan, Ning; Lin, Haoming; Liu, Fulong; Diao, Xingchun; Dong, Changfeng; Chen, Xin; Wang, Tianfu; Chen, Siping

doi:10.1016/j.ultrasmedbio.2014.12.017

Cited by 12 publications

(13 citation statements)

References 33 publications

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“…On the other hand, a mechanical model that can incorporate the effects of thickness would improve the accuracy of quantifying biomechanical properties [35,62]. Nevertheless, the SWE can be used to obtain a reasonable first-order estimate of Young's modulus [63].…”

Section: Discussionmentioning

confidence: 99%

Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography

Singh

Han

et al. 2016

Biomed. Opt. Express

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In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Young's modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the Young's modulus and elastic anisotropy of the cornea and their changes as a function of IOP and CXL, opening new avenues of research for evaluating the effects of CXL on corneal biomechanical properties.

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Section: Discussionmentioning

confidence: 99%

Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography

Singh

Han

et al. 2016

Biomed. Opt. Express

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“…1). Currently, imaging systems employed in micro-elastography are based on both clinical and laboratory imaging modalities, including MRI (1.5 Tesla (T) to 14T), 57,80,96,98,115,161 ultrasound (6–50 MHz) 69,87,104,123,138,164 and OCT 33,54,71,75,102,151 (Table 1). …”

Section: The Value Of Elastography In Biomaterials and Tissuesmentioning

confidence: 99%

“…164 Instead of using shear waves, 103,104 the dispersion of vibration in the cornea was modeled as a surface wave propagating as a Lamb wave on a viscoelastic substrate. This approach is applicable to characterization of biomaterial substrates with thickness of less than 1 mm.…”

Section: Ultrasound Elastographymentioning

confidence: 99%

“…While only ARFI, SWEI and SSI have been discussed, imaginative combinations of pulse generation techniques ultimately may provide further advancement of current tissue engineering-oriented UE. In particular, ARF UE offers non-contact remote-controlled tissue forcing and rapid acquisition of elasticity and even viscoelastic properties of tissue, 164 the latter of which is currently not easily achievable by other types of elastography techniques.…”

Section: Ultrasound Elastographymentioning

confidence: 99%

“…However, with a number of successful studies—high resolution strain elastograms, 138 viscoelasticity, 88,164 in vivo measurements 104 and 2D stiffness elastograms in vivo 123 —have come to a point that any of these techniques can be applied to monitoring of stiffness in biomaterials and tissue engineering constructs.…”

Section: Ultrasound Elastographymentioning

confidence: 99%

See 2 more Smart Citations

Application of Elastography for the Noninvasive Assessment of Biomechanics in Engineered Biomaterials and Tissues

et al. 2016

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The elastic properties of engineered biomaterials and tissues impact their post-implantation repair potential and structural integrity, and are critical to help regulate cell fate and gene expression. The measurement of properties (e.g., stiffness or shear modulus) can be attained using elastography, which exploits noninvasive imaging modalities to provide functional information of a material indicative of the regeneration state. In this review, we outline the current leading elastography methodologies available to characterize the properties of biomaterials and tissues suitable for repair and mechanobiology research. We describe methods utilizing magnetic resonance, ultrasound, and optical coherent elastography, highlighting their potential for longitudinal monitoring of implanted materials in vivo, in addition to spatiotemporal limits of each method for probing changes in cell-laden constructs. Micro-elastography methods now allow acquisitions at length scales approaching 5–100 μm in two and three dimensions. Many of the methods introduced in this review are therefore capable of longitudinal monitoring in biomaterials and tissues approaching the cellular scale. However, critical factors such as anisotropy, heterogeneity and viscoelasity—inherent in many soft tissues—are often not fully described and therefore require further advancements and future developments.

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Effective elastic modulus of an intact cornea related to indentation behavior: A comparison between the Hertz model and Johnson-Kendall-Roberts model

Ren

Chen

et al. 2021

Experimental Eye Research

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Measurement of Quantitative Viscoelasticity of Bovine Corneas Based on Lamb Wave Dispersion Properties

Cited by 12 publications

References 33 publications

Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography

Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography

Application of Elastography for the Noninvasive Assessment of Biomechanics in Engineered Biomaterials and Tissues

Effective elastic modulus of an intact cornea related to indentation behavior: A comparison between the Hertz model and Johnson-Kendall-Roberts model

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