Measurement of pore size distribution and prediction of membrane filter virus retention using liquid–liquid porometry

Giglia, Sal; Bohonak, David M.; Greenhalgh, Patricia; Leahy, Anne

doi:10.1016/j.memsci.2014.11.053

Cited by 32 publications

(17 citation statements)

References 21 publications

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“…The liquid-liquid displacement method was used as proposed by Erbe [25] and Bechhold et al [26]. This method is a standard industrial method used for characterizing filters in the wet state under the close-to-operational conditions, including virus removal filters, e.g., Viresolve by Merck Millipore [9]. Two immiscible liquids were used for LLP, i.e.…”

Section: Methodsmentioning

confidence: 99%

“…The flow weighted pore-size distribution was calculated using Equations (2) and (3) as described by S. Giglia et al [9]:R(∆P)=Q2phase(∆P)QIntrusion fluid(∆P) FQ(r)=normald(R(∆P))normald(∆P) · ∆P22kγcosθ where Q 2 phase (Δ P ) is the volumetric flow of intrusion liquid when the wetting fluid is present in the membrane at a set pressure, Q Intrusion fluid (Δ P ) is the volumetric flow of intrusion fluid in absence of wetting fluid present in the membrane, Δ P is the pressure, F Q ( r ) is the flow weighted pore-size distribution, k is the shape factor which is set to 1 approximating a cylindrical pore shape, and γ is the interfacial surface tension between the two fluids, which has been reported as approximately 6.3 × 10 −4 N at 22 °C [27]. The measured volumetric two-phase flow data were fitted to a weighted smooth spline function using Matlab.…”

Section: Methodsmentioning

confidence: 99%

“…In this respect, two wet-porometry methods that are useful to probe mesoporous materials include liquid-liquid porometry (LLP) and cryoporometry with differential scanning calorimetry (CP-DSC). LLP is an isothermal method that is based on replacement of one pore-filling liquid with another immiscible liquid, wherein the pore size is related to applied pressure needed to replace two liquids with each other based on the Hagen-Poiseuille equation [8,9]. CP-DSC is an isobaric method, which relates the pore size to the melting pressure depressing of water present in pores as compared to bulk water situated outside the pores [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative Analysis of Dry and Wet Porometry Methods for Characterization of Regular and Cross-Linked Virus Removal Filter Papers

et al. 2018

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Pore-size distribution (PSD) is the most critical parameter for size-exclusion virus removal filters. Yet, different dry- and wet-state porometry methods yield different pore-size values. The goal of this work is to conduct comparative analysis of nitrogen gas sorption (NGSP), liquid-liquid and cryoporometry with differential scanning calorimetry (CP-DSC) methods with respect to characterization of regular and cross-linked virus removal filter paper based on cellulose nanofibers, i.e. the mille-feuille filter. The filters were further characterized with atomic force and scanning electron microscopy. Finally, the removal of the worst-case model virus, i.e. minute virus of mice (MVM; 20 nm, nonenveloped parvovirus) was evaluated. The results revealed that there is no difference of the obtained PSDs between the wet methods, i.e. DSC and liquid-liquid porometry (LLP), as well as no difference between the regular and cross-linked filters regardless of method. MVM filtration at different trans membrane pressure (TMP) revealed strong dependence of the virus removal capability on applied pressure. It was further observed that cross-linking filters showed enhanced virus removal, especially at lower TMP. In all, the results of this study highlight the complex nature of virus capture in size-exclusion filters.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Analysis of Dry and Wet Porometry Methods for Characterization of Regular and Cross-Linked Virus Removal Filter Papers

et al. 2018

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“…Commercial virus filtration membranes that use size exclusion as the primary filtering mechanism require a high degree of control over the pore size distribution; where a larger pore sizes reduces the filters ability to retain the virus[ 122 ]. To create a reproducible filter using emulsion templating, every mixing aspect of the initial emulsion has to be controlled.…”

Section: Emulsion Reproducibility and Scalabilitymentioning

confidence: 99%

Considerations Using Additive Manufacture of Emulsion Inks to Produce Respiratory Protective Filters Against Viral Respiratory Tract Infections Such as the COVID-19 Virus

Sherborne¹,

Claeyssens²

2024

IJB

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This review paper explores the potential of combining emulsion-based inks with additive manufacturing (AM) to produce filters for respiratory protective equipment (RPE) in the fight against viral and bacterial infections of the respiratory tract. The value of these filters has been highlighted by the current severe acute respiratory syndrome coronavirus-2 crisis where the importance of protective equipment for health care workers cannot be overstated. Three-dimensional (3D) printing of emulsions is an emerging technology built on a well-established field of emulsion templating to produce porous materials such as polymerized high internal phase emulsions (polyHIPEs). PolyHIPE-based porous polymers have tailorable porosity from the submicron to 100 s of μm. Advances in 3D printing technology enables the control of the bulk shape while a micron porosity is controlled independently by the emulsion-based ink. Herein, we present an overview of the current polyHIPE-based filter applications. Then, we discuss the current use of emulsion templating combined with stereolithography and extrusion-based AM technologies. The benefits and limitation of various AM techniques are discussed, as well as considerations for a scalable manufacture of a polyHIPE-based RPE.

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“…Note that the function f(D) is called "the permeance probability density function" [21] or "the flow-weighted" PSD [22]. The average pore diameter was calculated in the usual way:…”

Section: Study Of Pore Size and Membrane Permeancementioning

confidence: 99%

Phase Separation within a Thin Layer of Polymer Solution as Prompt Technique to Predict Membrane Morphology and Transport Properties

et al. 2020

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In this work, the precipitation of a thin layer of a polymer solution was proposed to imitate the process of asymmetric membrane formation by a non-solvent induced phase separation (NIPS) technique. The phase inversion within the thin (<500 μm) and bulk (~2 cm) layer of polyamic-acid (PAA) in N-methyl-2-pyrrolidone (NMP) by using water as non-solvent was considered. It was shown that polymer films formed within the “limited” layer of polymer solution showed a good agreement with the morphology of corresponded asymmetric flat-sheet membranes even in the case of three-component casting solution (PAA/NMP/EtOH). At the same time, the polymer films formed on the interface of two bulk phases (“infinite” regime) did not fully correspond to the membrane structure. It was shown that up to 50% of NMP solvent in PAA solution can be replaced by ethanol, which can have a renewable origin. By changing the ethanol content in the casting solution, the average size of transport pores can be varied in the range of 12–80 nm, and the liquid permeance from 16.6 up to 207 kg/m2∙h∙bar. To summarize, the precipitation of polymer solution within the thin layer can be considered a prompt technique and a powerful tool for fast screening and optimization of the complex composition of casting solutions using its small quantity. Furthermore, the prediction of membrane morphology can be done without casting the membrane, further post-treatment procedures, and scanning electron microscopy (SEM) analysis.

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Measurement of pore size distribution and prediction of membrane filter virus retention using liquid–liquid porometry

Cited by 32 publications

References 21 publications

Comparative Analysis of Dry and Wet Porometry Methods for Characterization of Regular and Cross-Linked Virus Removal Filter Papers

Comparative Analysis of Dry and Wet Porometry Methods for Characterization of Regular and Cross-Linked Virus Removal Filter Papers

Considerations Using Additive Manufacture of Emulsion Inks to Produce Respiratory Protective Filters Against Viral Respiratory Tract Infections Such as the COVID-19 Virus

Phase Separation within a Thin Layer of Polymer Solution as Prompt Technique to Predict Membrane Morphology and Transport Properties

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