Measurement of peripapillary retinal nerve fiber layer thickness and macular thickness in anisometropia using spectral domain optical coherence tomography: a prospective study

Singh, Neha; Rohatgi, Jolly; Gupta, Ved Prakash; Kumar, Vinod

doi:10.2147/opth.s123273

Cited by 11 publications

(12 citation statements)

References 36 publications

(49 reference statements)

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“…Another limitation of our Journal of Ophthalmology study is that there was a difference in terms of astigmatism between two groups. Although there are publications in the literature that astigmatism may not affect RNFL measurements [24,25], the significant difference between the two groups in terms of astigmatism is the limitation of our study.…”

Section: Discussionmentioning

confidence: 81%

Ophthalmologic Manifestations and Retinal Findings in Children with Down Syndrome

Uğurlu

Altınkurt

2020

Journal of Ophthalmology

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Purpose. To evaluate ocular findings in children with Down syndrome and to compare with the healthy children group. Methods. The study patients were divided into two groups as the diagnosed Down syndrome group and the control group. The study was designed as a prospective and single-center study in Istanbul University Faculty of Medicine Department of Ophthalmology. The study included 93 patients in the age range from 7 to 18 years, who applied to the ophthalmology department of our clinic in the period from July 2017 to June 2018. The study included the patients allocated into the control group and the Down syndrome patients allocated into the patient group, containing 49 and 44 participants, respectively. All patients underwent complete ophthalmologic examination with biomicroscopy. Autorefractometer measurements were performed in all patients, and the best corrected visual acuity (BCVA) was determined with the use of the Snellen chart. All patients underwent spectral domain optical coherence tomography (SD-OCT) measurements for central foveal retinal (CRT), subfoveal choroidal (CCT), and peripapillary retinal nerve fiber layer (pRNFL) thicknesses. Results. The average CRT was 241.2 ± 25.7 microns in Down syndrome group and 219.4 ± 21.1 microns in the control group. There was a statistically significant difference between the groups in regards to CRT (p<0.001). The average pRNFL values were 123.1 ± 15.4 microns in the Down syndrome group and 102.2 ± 8.7 microns in the control group (p<0.001). Conclusions. In the subjects with Down syndrome, the incidence of lens opacities, strabismus, and amblyopia was higher than the control group. CRT and pRNFL were thicker in the Down syndrome group than in control group. This may represent retinal developmental changes in the patients with Down syndrome.

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Section: Discussionmentioning

confidence: 81%

Ophthalmologic Manifestations and Retinal Findings in Children with Down Syndrome

Uğurlu

Altınkurt

2020

Journal of Ophthalmology

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“…OCT offered reliable and accurate crosssectional imaging of the retinal structure and evaluation of the retinal changes accompanying amblyopia. However, evidences for direct retinal changes in amblyopia remain controversial [9,16]. In the current study we compared the peripapillary RNFL thickness, macular parameters, and GCL+ thickness of amblyopic eyes (group A) with that of fellow normal eyes (group B) and normal control eyes of non-amblyopic subjects (group C) using SD-OCT.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies examined the amblyopic retinal thickness using OCT and the degree of retinal involvement accompanying amblyopia is controversial. Some of these studies reported no differences between amblyopic and their healthy normal fellow eyes [6][7][8][9][10], whereas others reported significant differences between amblyopic and healthy eyes [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Retinal Nerve Fiber Layer Thickness and Macular Ganglion Cell Evaluation in Unilateral Amblyopia using Optical Coherence Tomography

El-Fiky¹,

Fayed²,

El-Nagar³

2020

Benha Journal of Applied Sciences

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The aim of the current study is to evaluate retinal nerve fiber layer (RNFL) thickness, macular parameters and ganglion cell thickness (GCL+) in unilateral anisometropic amblyopic eye in relation to the normal healthy fellow eye and control one using spectral domain optical coherence tomography (SD-OCT). This study included 56 eyes of 28 cases aged from 8-30 years old subdivided into: 20 amblyopic eyes of patients with unilateral anisometropic amblyopia (group A), 20 sound fellow eyes of the unilateral anisometropic amblyopic patients (group B) and 16 emmetropic eyes of normal non amblyopic control (group C). Anisometropic amblyopic patients further subdivided according to refractive error into hypermetropic, myopic, and astigmatic amblyopic subgroups. All cases underwent detailed ophthalmic examination including visual acuity by Snellen's chart, cycloplegic refraction, ocular motility and alignment test, slit lamb biomicroscopy, intraocular pressure, fundus examination and OCT imaging by SD-OCT. Regarding peripapillary RNFL thickness, macular parameters including (central macular thickness (CMT), average macular thickness and macular volume), and GCL+ thickness, there was no significant difference among the amblyopic, fellow eyes, and normal eyes of non-amblyopic group, P˃0.05 . By further analysis to compare subgroups according to the refractive error between amblyopic and their fellow eyes, peripapillary RNFL thickness revealed a significant increase in amblyopic eyes of hypermetropic (mean 121.750±8.647µm) and astigmatic subgroups (mean 111.888±7.043µm) compared with their fellow eyes (116.125±8.509 and 107.333±6.480) respectively, but it was significantly thinner in myopic amblyopic eyes (mean 81.333±23.352µm) than that of their fellow eyes (mean 110.00±17.578). CMT revealed a significant increase in myopic amblyopic eyes (mean 199.00±26.851µm) compared with their fellow eyes (mean 191.00±26.00µm). Other OCT parameters did not significantly differ between amblyopic and their fellow eyes in different subgroups. OCT parameters including peripapillary RNFL thickness, macular parameters, and GCL+ thickness showed no significant difference among the amblyopic, fellow eyes, and normal eyes of non-amblyopic group. Hypermetropic and astigmatism amblyopic eyes showed increased peripapillary RNFL thickness than their fellow eyes, while myopic amblyopic eyes had decreased peripapillary RNFL thickness than their fellow eyes. CMT revealed a significant increase in amblyopic eyes of the myopic anisometropic subgroup compared with their fellow eyes.

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“…Unlike the macular vessel system, our data showed unchanged mean macular thickness in unilateral anisometropic amblyopes and in successfully treated anisometropic amblyopic children after adjustment for the AL. Many studies using OCT have examined retinal thickness of amblyopia and evaluated the reversal of difference after treatment with varied methodologies [33][34][35][36][37] . It is reported studies that showed difference in retinal thicknesses tend to show increased thickness associated with amblyopia.…”

Section: Discussionmentioning

confidence: 99%

Effect of amblyopia treatment on macular microvasculature in children with anisometropic amblyopia using optical coherence tomographic angiography

Zhang

Xie

Liu

et al. 2021

Sci Rep

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To measure the retinal microvascular density in patients with anisometropic amblyopia using optical coherence tomographic angiography (OCTA) and to evaluate the effects of successful amblyopia treatment on microvasculature in retina. 59 children (5–12 years old) including 22 newly diagnosed unilateral anisometropic amblyopia, 16 recovered unilateral anisometropic amblyopia, and 21 control children were imaged with OCTA using 6 × 6-mm macular scan pattern. Vessel densities of the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and the overall macular thickness were acquired and compared among the three groups. After adjustment for axial length, the amblyopia group showed lower macular vessel density in the SCP (P = 0.005) and in the DCP (P = 0.004) compared with that of the control group. However, for the recovered amblyopia group, no difference of vessel density was found when compared with the control group in both the SCP (P = 0.548) and the DCP (P = 0.124). No difference of the mean macular thickness was found among three groups (P ≥ 0.15). Children with anisometropic amblyopia have reduced macular vessel density in OCTA, while no difference of macular vessel density was found between the recovered amblyopic and control eyes. Macular thickness showed no difference in anisometropic amblyopia and remained unchanged after amblyopic treatment.

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Measurement of peripapillary retinal nerve fiber layer thickness and macular thickness in anisometropia using spectral domain optical coherence tomography: a prospective study

Cited by 11 publications

References 36 publications

Ophthalmologic Manifestations and Retinal Findings in Children with Down Syndrome

Ophthalmologic Manifestations and Retinal Findings in Children with Down Syndrome

Retinal Nerve Fiber Layer Thickness and Macular Ganglion Cell Evaluation in Unilateral Amblyopia using Optical Coherence Tomography

Effect of amblyopia treatment on macular microvasculature in children with anisometropic amblyopia using optical coherence tomographic angiography

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