Measurement of nutrient intake by deuterium dilution in premature infants

Peppard, Rory J.; Karn, Cheryl A.; McCabe, Michael A.; Wassall, Stephen R.; Liechty, Edward A.; Denne, Scott C.

doi:10.1016/s0022-3476(05)81756-1

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…Milk intake was estimated between 1 and 2 wk of age in a subset of lambs using deuterium oxide (D 2 O) dilution, which also assessed body water (17,18). During this time, lambs were in a pen with their mother with no access to any alternative milk source and were removed from their mother only briefly during blood collection and weighing.…”

Section: Methodsmentioning

confidence: 99%

Periconceptional Events Perturb Postnatal Growth Regulation in Sheep

et al. 2011

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Periconceptional undernutrition and twin conception alter intrauterine growth and metabolism and are associated with later adverse metabolic outcomes. The contribution of postnatal growth to these outcomes is less well defined. We investigated whether maternal periconceptional undernutrition or twin conception altered postnatal growth regulation in ways that could lead to metabolic disease. Single and twin offspring of ewes undernourished (UN) from 61 d before until 30 d after mating, fed to achieve and maintain 10 -15% weight loss (UN), were compared with offspring of maintenance-fed controls (N). At 2 h and 1, 6, and 12 wk after birth, lambs were weighed and plasma hormone and metabolite concentrations analyzed. Milk intake, measured by deuterium oxide dilution, was inversely related to birth weight only in N singles, although twins had the greatest postnatal growth velocity. Positive associations were seen between milk intake, growth velocity, and leptin concentrations in N, but not UN, offspring. We conclude that periconceptional undernutrition alters the relationships between regulators of postnatal growth, including nutrient intake and key hormonal axes, in both singles and twins without affecting size at birth or postnatal growth velocity. Dissociation of growth from its key regulators is one possible mechanism underlying adverse metabolic outcomes after periconceptional undernutrition. (Pediatr Res 70: 261-266, 2011)

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Section: Methodsmentioning

confidence: 99%

Periconceptional Events Perturb Postnatal Growth Regulation in Sheep

et al. 2011

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“…Peppard et al 39 Thirteen hospitalized preterm infants age The Pearson correlation between intake estimated by the doubly labeled water procedure and direct measurement was 0.93. The doubly labeled water procedure overestimated intake by 15% when compared with direct measurement (302 vs. 262 mL/d).…”

Section: Direct Observationmentioning

confidence: 98%

“…The validity of using doubly labeled water to measure the milk intake of formula-fed infants was evaluated in seven studies (Table 4). 25,[36][37][38][39][40][41] All the studies compared the method with direct measurement of formula, measuring either the weight or volume of formula consumed.…”

Section: Doubly Labeled Watermentioning

confidence: 99%

“…Length of the doubly labeled water study periods ranged from 5 38,40 to 15 25 days. Although the study populations varied and included healthy infants, 36,38,41 preterm infants, 39,40 and infants from developing countries recovering from protein-energy malnutrition, 25,37 all mean differences between the doubly labeled water procedure and direct measurement of formula were within 15%.…”

Section: Doubly Labeled Watermentioning

confidence: 99%

“…Only four of the seven studies adjusted the doubly labeled water calculations for insensible water losses and environmental water in ux. [36][37][38][39] As indicated, such activities can be important. For example, Butte et al 38 reported that the doubly labeled water method overestimated formula intake by 8% when compared with direct measurement, but after adjustment for environmental water in ux and insensible water losses the overestimate was only 1% to 2%.…”

Section: Doubly Labeled Watermentioning

confidence: 99%

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Assessment of Infant Feeding: the Validity of Measuring Milk Intake

et al. 2002

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Accurate assessment of infant feeding is needed for clinical practice and research. We identified 32 studies that evaluated the validity of direct observation, test weighing, or doubly labeled water methods. Correlations with validation standards were highest for doubly labeled water and test weighing, and lowest for observation. Cost and availability of isotope may limit the doubly labeled water method to research studies, whereas observation may be useful for clinical practice. Test weighing could be applied to either setting, but it may be practical to sample less frequently over 24 hours. Validity results and intended use of the measurement should be considered when selecting a method.

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