Measurement of Glomerular Filtration Rate by Contrast Media Containing I-131 Isotopes

Stokes, James; Conklin, J. W.; Huntley, H.C.

doi:10.1016/s0022-5347(17)65017-1

Cited by 22 publications

(7 citation statements)

References 2 publications

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“…Based on clearance studies in man and dog, apical and basolateral uptake of diatrizoate has been postulated. From kidney cortex slices (Mudge et al 1971) and clearance studies (Denneberg 1966;Donaldson 1968;Stokes et al 1962) it has been suggested that diatrizoate uptake occurs in a manner similar to organic anion transport systems. Indeed, probenecid has been found to block diatrizoate uptake (Mudge et al 1971).…”

Section: Discussionmentioning

confidence: 99%

Contrast media induced changes in tubular electrophysiology and glomerular filtration rate in the mouse kidney

Morgunov¹,

Foster²,

Hirsch³

1997

Can. J. Physiol. Pharmacol.

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The isolated perfused mouse proximal tubule was used to examine electrophysiologic effects of diatrizoate and ioversol. Luminal or basolateral application of diatrizoate resulted in a dose-dependent, reversible hyperpolarization of the proximal tubule cell basolateral membrane potential (VB), which could be abolished by the addition of 10 microM probenecid. While there was a modest reduction in intracellular ATP following a 60-min exposure to diatrizoate, there was no deterioration of VB after 90 min of diatrizoate exposure, even following a 20-min hypoxic insult. Ioversol did not elicit an electrical response. Neither diatrizoate nor ioversol significantly affected transepithelial potential (VT) in the isolated perfused medullary thick ascending limb. In vivo studies showed that only the ionic contrast agent diatrizoate significantly reduced glomerular filtration rate, by 70%. The observed acute contrast media induced reduction in glomerular filtration rate does not appear to depend on direct renal tubular cytotoxicity.

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Section: Discussionmentioning

confidence: 99%

Contrast media induced changes in tubular electrophysiology and glomerular filtration rate in the mouse kidney

Morgunov¹,

Foster²,

Hirsch³

1997

Can. J. Physiol. Pharmacol.

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“…However, significant tubular secretion was calculated in two other reports after applying a correction factor for plasma binding [11,12]. In another paper, tubular reabsorption was reported [25]. By the stop-flow technique, the diatrizoate pattern was similar to that of creatinine [34].…”

Section: Introductionmentioning

confidence: 95%

Renal Transport of Diatrizoate in the Rabbit, Dog, and Rat

Mudge¹,

Berndt²,

Saunders³

et al. 1971

Nephron

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The renal transport of ¹²⁵I-diatrizoate was examined in three species, dog, rabbit, and rat. In the rabbit this organic acid behaved like many such compounds, i.e. it was secreted by the proximal tubular organic anion process as judged by stop-flow analysis. The proximal tubular peak was abolished by probenecid. In vitro experiments with renal cortex slices gave results entirely consistent with the in vivo studies. Diatrizoate uptake by the slices was an energy-dependent, saturable process that was blocked by several organic acids known to be accumulated by the organic acid transport system. Rat renal cortex slices showed significant diatrizoate uptake, although of a lesser magnitude than noted with rabbit tissue (rat S/M = 1–2; rabbit S/M = 3–5). Except for the failure of acetate to stimulate diatrizoate uptake, accumulation by the rat slices appeared to be by the organic acid transport process. On the other hand, dog slices failed to accumulate diatrizoate. The process was not stimulated by acetate or any other metabolic substrate nor was it blocked by metabolic inhibitors or various organic acid competitors. No evidence of proximal tubular secretion was noted in the dog using stop-flow analysis; diatrizoate-inulin U/P ratios were approximately 0.9. Furthermore in p-amino-hippurate (PAH) clearance experiments in the dog, administration of diatrizoate failed to alter PAH clearance. These data indicate active renal transport of diatrizoate in certain species, but not in others.

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“…Although some tubular transport may occur at low doses [14,20,26,27] this becomes insignificant at doses used clinically. In the present study the upper half of our dose range covers the spectrum of clinical usage.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dose on Renal Diatrizoate Concentrations in Experimental Acute Renal Failure

Robinson¹,

Gaunt²,

McLachlan³

1976

Nephron

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In rats with glycerol-induced acute renal failure (ARF) and controls, renal concentrations of ¹²⁵I-labelled sodium diatrizoate were measured 5 min after intravenous doses ranging from 14 to 1,800 mg/kg body weight. Renal concentrations of diatrizoate, at all doses, were much higher in controls than in ARF. A linear relationship existed between dose and renal concentration in ARF. In controls, at doses above 225 mg/kg body weight, the fraction of the dose present in the kidneys diminished and renal iodine content approached that observed in ARF. Differences in diatrizoate concentration which existed between cortical and medullary zones in healthy kidneys at low doses were progressively eliminated as dosage increased, consistent with the osmotic diuretic effect of diatrizoate. In ARF, the pattern of intrarenal distribution at all doses was similar to that seen in controls at high doses, though concentrations in outer cortex were consistently slightly higher than those in inner cortex. These observations suggest continuing, though reduced, filtration of diatrizoate in ARF by glomeruli already subjected to a large solute load.

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Measurement of Glomerular Filtration Rate by Contrast Media Containing I-131 Isotopes

Cited by 22 publications

References 2 publications

Contrast media induced changes in tubular electrophysiology and glomerular filtration rate in the mouse kidney

Contrast media induced changes in tubular electrophysiology and glomerular filtration rate in the mouse kidney

Renal Transport of Diatrizoate in the Rabbit, Dog, and Rat

Effect of Dose on Renal Diatrizoate Concentrations in Experimental Acute Renal Failure

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