Measurement of drug agglomerates in powder blending simulation samples by near infrared chemical imaging

Li, Weiyong; Woldu, Abraham; Kelly, Richard N.; McCool, Jim; Bruce, Rick; Rasmussen, Henrik T.; Cunningham, J. C.; Winstead, Denita

doi:10.1016/j.ijpharm.2007.08.055

Cited by 49 publications

(16 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Li et al . described the influence of mean particle size and size distribution on the blending behaviour of the API . Different API fractions (60, 80, 100, 120, 200, and 325 mesh) were blended with two excipients (HPMC and MCC) for 20 min and the samples were analyzed using NIR‐CI.…”

Section: Nir‐ci Applications To the Western Solid Dosage Formsmentioning

confidence: 99%

“…Li et al described the influence of mean particle size and size distribution on the blending behaviour of the API. [42] Different API fractions (60, 80, 100, 120, 200, and 325 mesh) were blended with two excipients (HPMC and MCC) for 20 min and the samples were analyzed using NIR-CI. In this study, spectral data cubes of pure API and two excipients were collected to establish a PLS2 model, which was then used to calculate the concentration cube for each NIR-CI data cube.…”

Section: Blending Processmentioning

confidence: 99%

See 1 more Smart Citation

PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR‐CI

Zhou

et al. 2015

Drug Testing and Analysis

View full text Add to dashboard Cite

Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed.

show abstract

Section: Nir‐ci Applications To the Western Solid Dosage Formsmentioning

confidence: 99%

Section: Blending Processmentioning

confidence: 99%

PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR‐CI

Zhou

et al. 2015

Drug Testing and Analysis

View full text Add to dashboard Cite

show abstract

“…Another small-scale experiment was reported by Li et al [25], who studied blend uniformity with the objective of measuring the effect of API particle size (i.e., sieve fraction) on blending behavior as a function of time. Small volumes of powder blends were prepared in 20 mL scintillation vials using a benchtop rotating mixer (Glas-Col brand, Terre Haute, IN, USA) and measured using an FPA-based chemical imaging system (Malvern Instruments).…”

Section: Blend Uniformity Of Powder Samplesmentioning

confidence: 99%

NIR Imaging Applications in the Pharmaceutical Industry

Gerich¹,

Dubois²,

Kidder³

2010

Raman, Infrared, and Near‐Infrared Chemical Imaging

View full text Add to dashboard Cite

“…The collected data contribute to qualitative and quantitative information (also known as chemical imaging, CI) about pharmaceutical tablets, enabling the collection of high fidelity, spatially resolved pictures of the chemistry of the sample. A variety of NIR chemical imaging (NIR-CI) applications are documented in the pharmaceutical field, including the study of homogeneity of powder samples (Ma et al, 2007), particle size determination (Li et al, 2008), determination of concentrations, and distribution of components in solid tablets and content uniformity (Cruz et al, 2011). NIR hyperspectral CI is the most widely used qualitative analysis method that provides information about the chemical distribution in the drug samples, such as the API and excipient ingredients (Palou et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Techniques for Nondestructive Quality Inspection of Pharmaceutical Products: A Review

Kandpal

Park

Tewari

et al. 2015

Journal of Biosystems Engineering

View full text Add to dashboard Cite

Spectroscopy is an emerging technology for the quality assessment of pharmaceutical samples, from tablet manufacturing to final quality assurance. The traditional methods for the quality management of pharmaceutical tablets are time consuming and destructive, while spectroscopic techniques allow rapid analysis in a non-destructive manner. The advantage of spectroscopy is that it collects both spatial and spectral information (called hyperspectral imaging), which is useful for the chemical imaging of pharmaceutical samples. These chemical images provide both qualitative and quantitative information on tablet samples. In the pharmaceutics, spectroscopic techniques are used for a variety of applications, such as analysis of the homogeneity of powder samples as well as determination of particle size, product composition, and the concentration, uniformity, and distribution of the active pharmaceutical ingredient in solid tablets. This review paper presents an introduction to the applications of various spectroscopic techniques such as hyperspectroscopy and vibrational spectroscopies (Raman spectroscopy, FT-NIR, and IR spectroscopy) for the quality and safety assessment of pharmaceutical solid dosage forms. In addition, various chemometric techniques that are highly essential for analyzing the spectroscopic data of pharmaceutical samples are also reviewed.

show abstract

Measurement of drug agglomerates in powder blending simulation samples by near infrared chemical imaging

Cited by 49 publications

References 6 publications

PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR‐CI

PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR‐CI

NIR Imaging Applications in the Pharmaceutical Industry

Spectroscopic Techniques for Nondestructive Quality Inspection of Pharmaceutical Products: A Review

Contact Info

Product

Resources

About