Measurement of Dietary and Dentifrice Effects Upon Calculus Accumulation Rates in the Domestic Ferret

Harper, D. Scott; Mann, P.H.; Regnier, S.

doi:10.1177/00220345900690020501

Cited by 23 publications

(11 citation statements)

References 18 publications

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“…The formula is I 2/2, C 1/1, Pm 4/4, M 2/2. Ligature-induced periodontitis was obtained within 4 weeks [102, 103]. The evolution in the periodontal lesions was quite similar to that observed in humans.…”

Section: The Different Animal Models In Periodontologymentioning

confidence: 91%

Experimental Animal Models in Periodontology: A Review

Struillou¹,

Boutigny²,

Soueidan³

et al. 2010

TODENTJ

192

206

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In periodontal research, animal studies are complementary to in vitro experiments prior to testing new treatments. Animal models should make possible the validation of hypotheses and prove the safety and efficacy of new regenerating approaches using biomaterials, growth factors or stem cells. A review of the literature was carried out by using electronic databases (PubMed, ISI Web of Science). Numerous animal models in different species such as rats, hamsters, rabbits, ferrets, canines and primates have been used for modeling human periodontal diseases and treatments. However, both the anatomy and physiopathology of animals are different from those of humans, making difficult the evaluation of new therapies. Experimental models have been developed in order to reproduce major periodontal diseases (gingivitis, periodontitis), their pathogenesis and to investigate new surgical techniques. The aim of this review is to define the most pertinent animal models for periodontal research depending on the hypothesis and expected results.

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Section: The Different Animal Models In Periodontologymentioning

confidence: 91%

Experimental Animal Models in Periodontology: A Review

Struillou¹,

Boutigny²,

Soueidan³

et al. 2010

TODENTJ

192

206

View full text Add to dashboard Cite

show abstract

“…Fortunately, artificial milk diets and supplements are the only variations to the natural diet now days Hume, 1991, Pahl andHume, 1986). However, artificial milk and supplement diets have shown in other species to be potential factors in the increase of periodontal disease cases (Holloway et al, 1961, Ashley and Naylor, 1970, Harper et al, 1990, Vosburgh et al, 1982. The natural koala diet of leaf material is highly abrasive, which helps in cleansing the mouth.…”

Section: Dietmentioning

confidence: 99%

Oral health in South East Queensland Koalas: Prevalence of periodontal disease and other pathologies

Pettett¹

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The koala (Phascolarctos cinereus) is one of Australia's most highly specialised folivores with a diet exclusively of eucalyptus leaves to provide all nutritive needs. For this it is dependent on good dentition for optimal health and quality of life. The purpose of this study was to characterise and describe the level of oral health and disease in koalas and then create tools for ongoing analysis.The historical records over a 17-year period were noted for the koalas admitted to the Moggill Koala Hospital in South East Queensland. Further, in this study the conclusions were that oral health issues when they existed were only being identified as "low key" due to the lack of investigative tools being used during examinations. This provided the reasoning and impetus behind developing tools to determine the true extent of oral health conditions in the koala. A suitable assessment tool for diagnosing the oral health was designed based on the index scoring methodology and the layout of the Moggill Koala Hospital admission chart, a new oral health chart template was developed. The chart was based on examination of 30 "free-range koalas" and validation and quality assurance analysis of four examiners of varying qualifications. The chart was separated into three sections; containing general animal information such as sex, age, and current systemic health; the General Oral Cavity section and containing information on 12 koala-specific health questions and finally a section on the periodontal health. The charting data is multifunctional with analysis of individual koalas, (sex, group or age). The data from each section provided an index value that was compatible with values from other species clinical charting systems.Using the chart, populations of 200 "free-range" and 95 captive koalas (from three zoos) were examined. Three major indexes were developed during the chart development process and used the following equation; General Oral Cavity (GOCI) + Oral Health Index (OHI) = Final Oral Health Index (FOHI). Initially, the three major index values plus all additional information of each chart were analysed to show the current baseline values of oral health conditions in the koala. Any ii comparison based on singular or multiple animals would either show a decline, same rate or increase from the baseline. These baseline parameters could be compared against any other species that uses the same 0-3 index system.The proportion of koalas from the whole population with an orally related problem was 86%.The average FOHI for the koala as a species was 3.78 ± 3.19, median 3.00. This is the mild category and held 84.5% of all cases. The maximum scores for the groups showed Zoo 3 as having lower range (Zoo 1; 11.42 for a TWC 1 male, Zoo 2; 13.40, Zoo 3; 4.13 and "free-range"; 15.98). The third zoo was the only group to have also had significantly better oral health than "free-range" koalas.Captive koalas showed high scoring at young age (11.42), the "free-range" comparable age score was 3.84. At population level when controlli...

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“…Ferrets have deciduous and permanent dentitions, with two incisors, one canine, four premolars and two molars in the maxilla, and two incisors, one canine, four premolars and two molars in the mandible (163). The advantages of this preclinical model are related to the small size of the animal, the ease of handling and housing and the low purchase cost (67). Domestic ferret can be used to study plaque accumulation, calculus formation and inhibition (53,67), and gingivitis progression (67,135).…”

Section: Models In Ferretsmentioning

confidence: 99%

Description of the periodontal pocket in preclinical models: limitations and considerations

Donos¹,

Park²,

Vajgel³

et al. 2017

Periodontology 2000

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Establishment of periodontal health and regeneration of the lost periodontal tissues are always the ultimate goal of periodontal treatment. The development of new therapeutic approaches raises the necessity for appropriate experimental models that present periodontal structures and healing capability comparable to humans. Preclinical research and extrapolation of the data to human conditions remains a stage of great importance before the clinical application of the new biomaterials and techniques. Periodontal pockets/defects in preclinical models can be induced experimentally through acute or chronic or a combination of both (induced) modalities. The features of the created defects and those of humans vary greatly mostly due to the nature of the periodontal disease. This is an important point to take into account, since it is well recognized that the potential of periodontal therapy may be dependent on both the biological background and the defect morphology. This review provides insight into the commonly used preclinical models for the reproduction of the periodontal pocket and discusses the advantages and disadvantages of each model in terms of similarity to human conditions, standardization and reproducibility.

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Measurement of Dietary and Dentifrice Effects Upon Calculus Accumulation Rates in the Domestic Ferret

Cited by 23 publications

References 18 publications

Experimental Animal Models in Periodontology: A Review

Experimental Animal Models in Periodontology: A Review

Oral health in South East Queensland Koalas: Prevalence of periodontal disease and other pathologies

Description of the periodontal pocket in preclinical models: limitations and considerations

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