Measurement of cortisol and lymphocyte subpopulations in depressed and conduct-disordered adolescents

Targum, Steven D.; Clarkson, Lindsay L.; Magac‐Harris, Kelly; Marshall, Lois E.; Skwerer, Robert G.

doi:10.1016/0165-0327(90)90064-f

Cited by 30 publications

(15 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Boys with early emergence (by age 10 years) of the first CD symptom had lower cortisol concentrations than those with late emergence. Some earlier studies, [22][23][24] including one that focused on aggression, 25 produced dissimilar results. However, accrual of other direct and indirect evidence linking life-course-persistent aggression to low cortisol concentrations attests that the current findings are not isolated.…”

Section: Commentmentioning

confidence: 87%

Low Salivary Cortisol and Persistent Aggression in Boys Referred for Disruptive Behavior

McBurnett

Lahey

Rathouz³

et al. 2000

Arch Gen Psychiatry

429

278

View full text Add to dashboard Cite

Background: Persistent antisocial behavior in adulthood is often preceded by childhood-onset aggressive conduct disorder. Aggressive syndromes in both children and adults have previously been associated with abnormalities in peripheral responses to stress. One peripheral measure, salivary cortisol concentration, may reflect individual differences in the hypothalamic-pituitary-adrenal axis that underlie propensities for aggression, socialization, and adaptation to stress.

show abstract

Section: Commentmentioning

confidence: 87%

Low Salivary Cortisol and Persistent Aggression in Boys Referred for Disruptive Behavior

McBurnett

Lahey

Rathouz³

et al. 2000

Arch Gen Psychiatry

429

278

View full text Add to dashboard Cite

show abstract

“…The underlying mechanism may be an increased turnover of these activated cells under proinflammatory conditions reflected by increased C-reactive protein levels in maltreated children with depression [9]. Studies ignoring ACEs such as maltreatment may therefore fail to detect the association of adolescent depression and altered cellular immunity [30]. …”

Section: Discussionmentioning

confidence: 99%

Preliminary Evidence for a Compromised T-Cell Compartment in Maltreated Children with Depression and Posttraumatic Stress Disorder

Bielas

Jud²,

Lips³

et al. 2015

Neuroimmunomodulation

View full text Add to dashboard Cite

Objective: Adverse childhood experiences, such as maltreatment, and affective disorders are associated with a proinflammatory state and/or variably compromised counts in lymphocyte subsets in adults. Animal models of social stress indicate that recent thymic emigrant cells (RTE), which maintain the T-cell compartment, are affected. Methods: In this study, we examined the association between lymphocyte subsets, and depression and posttraumatic stress disorder (PTSD) among 16 maltreated children (aged 6-17 years) 1-3 years after the intervention by the Child Protection Team and among 14 healthy age-matched controls. The participants completed psychological assessment and had blood drawn for fluorescent-activated cell sorting analysis. Results: Among maltreated children and adolescents, depression was associated with lower counts of RTEs and T-helper cells after controlling for age. We found additional trends and large effect sizes with regard to the percentages of these cells, as well as for related lymphocyte subsets. Similar effects were found for PTSD, i.e. lower counts of naïve T cells, which was also supported by a trend for their percentage. Compared to controls, maltreated participants with a clinical level of depression had decreased percentages of RTEs, with a similar trend for PTSD. Conclusion: Limited by the nature of a pilot study and the small sample size, these preliminary findings of a compromised T-cell compartment related to psychiatric symptoms in maltreated children and adolescents need to be further studied; particularly the role of RTEs needs further evaluation.

show abstract

“…In an above mentioned research, measuring salivary T and CORT levels in 36 college students and 29 delinquent participants of a similar age, T levels were higher in violent delinquent adolescents than in normal college students; but CORT levels did not differed in any of the samples (Banks & Dabbs, 1996;Kruesi et al, 1989;Targum et al, 1990).…”

Section: Report Of the Studiesmentioning

confidence: 99%

Hormones and aggression in childhood and adolescence

Ramírez

2003

Aggression and Violent Behavior

View full text Add to dashboard Cite

This review is a survey on recent psychobiosocial studies on association between hormones and aggression/violence in children and adolescents, with a special focus on puberty, given the rapid changes in both hormones and behavior occurring during that developmental period. Since it cannot be assumed that all readers have much background knowledge, it inevitably begins with some comments about the concept and multifaceted nature of aggression, as well as with a brief reminding about hormone candidates to be linked to aggression during human development. Then, we finish off with the status of its knowledge in today's science, tackling in a systematic way with the main data published, hormone by hormone. The origin of the gender-based differences in aggression must lie in neuroendocrinological events occurring during prenatal life or early in postnatal life. A complex and indirect effect of testosterone on aggression is proposed. A low HPA axis activity seems associated with chronic aggressive and antisocial behaviors. It is also suggested that early adrenal androgens contribute to the onset and maintenance of persistent violent and antisocial behavior, and that it begins early in life and persists into adulthood, at least in young boys. There are also some studies suggesting an association between aggression and some pituitary hormones in children, even if present data are still far from being consistent. The hormone-aggression link during development thus is not consistently reported. There can be an indirect relation in three ways: hormones can be involved in the development of aggression as a cause, as a consequence, or even as a mediator. Psychosocial factors may influence the causation and progression of violence in children through hormonal action. D

show abstract

Measurement of cortisol and lymphocyte subpopulations in depressed and conduct-disordered adolescents

Cited by 30 publications

References 36 publications

Low Salivary Cortisol and Persistent Aggression in Boys Referred for Disruptive Behavior

Low Salivary Cortisol and Persistent Aggression in Boys Referred for Disruptive Behavior

Preliminary Evidence for a Compromised T-Cell Compartment in Maltreated Children with Depression and Posttraumatic Stress Disorder

Hormones and aggression in childhood and adolescence

Contact Info

Product

Resources

About