Measurement of Corpus Callosum Size Using MRI In Nepalese Population

Abstract

Corpus callosum (CC) is the main fiber tract connecting the cortical and sub-cortical regions of the right, left hemispheres, and plays an essential role in the integration of information between the two hemispheres. By using magnetic resonance imaging (MRI), the dimensions of corpus callosum can be studied. In this cross-sectional quantitative study 80 cases of normal MRI head were selected for study over two months. T1 weighted sagittal spin-echo images with slice thickness of 6 mm, planned from an axial and coronal image were used for measuring length and thickness of corpus callosum. Obtained data were analyzed using SPSS ver.20 software and shown in frequency, percentages and bar diagram. The mean Corpus callosum (CC) length was 68.06 mm in the study population (n=80). The mean thickness of Genu, Body and Splenium were 9.15,5.2 and 9.08 mm respectively and average thickness was 7.81 mm. Statistically significant differences in size of CC for various age groups in both sexes were observed. The mean length of CC was 68.06 mm and mean thickness of CC was 7.81 mm. There were variation in the size of CC with age and sex. The Pearson correlation Coefficient is 0.48829 between Age and Length of CC, its P-value is 0.0019 KEY WORD: Magnetic Resonance Imaging (MRI), Corpus callosum (CC), Genu, Body, Splenium Sagittal Spin-Echo.

Relationship of size of corpus callosum with white matter changes in elderly population; A retrospective analytical cross-sectional study

“…The mean length of the corpus callosum in our study patients was 7.25 cm which was comparable with the results by Gnawali S et al [ 5 ] and Takeda S et al [ 6 ]. Similarly, the thickness of the genu, body, splenium, and rostrum were consistent with the findings described by Gnawali S et al and Takeda S et al The white matter changes are described as WMH by neuroimaging in our study.…”

“…The majority of the studies have found the age-related thinning of CC. But the thinning has been found only modest in all of them [ [3] , [4] , [5] , [6] ]. The MRI has been a cornerstone in assessing the changes in the brain with age.…”

A comprehensive review on role of magnetic resonance imaging in the precise measurement of corpus callosum

“…This study's findings underscore the potential clinical utility of assessing CCa parameters to aid in the diagnosis and grading of cerebral atrophy. Gnawal S., et.al;(2021) 18 : Corpus callosum (CC) serves as the primary fiber tract connecting the right and left hemispheres, facilitating crucial information integration. This cross-sectional quantitative study utilized magnetic resonance imaging (MRI) to investigate CC dimensions in 80 cases with normal MRI head scans over a twomonth period.…”

“…In this comprehensive review on MRI role in corpus callosum measurement have reviewed on many research articles and the outcome about corpus callosum measurement have to variation in length of corpus callosum at different age groups between both sexes. We compare the reviewed outcome with some different authors study Weis S. et.al; (1993), 7 Rajapkase J. et.al; (1996), 8 Dorion A. et.al; (2001), 9 Chiara N. et.al; (2004), 10 Van K. et.al; (2008), 11 Rizzo G. et.al; (2011), 12 Mohammad M. et.al; (2011), 13 Garel C. et.al; (2011), 14 Gao Y. et.al; (2018), 15 Kamal A. et.al; (2019), 16 Ping J. et.al; (2020), 17 Gnawali S. et.al; (2021), 18 Berman S. et.al; (2018), 19 Bayar O. et.al; (2021). 20 Their parameter was significant and population have variation in length of corpus callosum at different age group between both sexes.…”