Measurement of chloroprocaine and procaine in plasma by flame ionization gas-liquid chromatography.

Smith, R. H.; Brewster, Marge A.; MacDonald, J A; Thompson, Dola S.

doi:10.1093/clinchem/24.9.1599

Cited by 9 publications

(2 citation statements)

References 4 publications

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“…Procaine is rapidly hydrolyzed by pseudocholinesterases, but addition of 1 mg of echothiopate to 1 ml of plasma ensured 100 % recovery of procaine. Plasma was separated and measured by high pressure liquid chromatography (20,22). (6): The response was recorded over the contralateral sensory-motor cortex following stimulation of the right median nerve.…”

Section: Resultsmentioning

confidence: 99%

Cerebral Blood Flow during Early Cardiopulmonary Bypass in Man. Effect of Procaine in Cardioplegic Solutions

Henriksen¹,

Di²,

Ih³

et al. 1986

Thorac cardiovasc Surg

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Cerebral blood flow (CBF), plasma procaine concentrations, and somatosensory evoked potentials (SSEP) were recorded in 2 groups of patients in whom either a high-procaine cardioplegic solution (Bretschneider's n = 29), or a low-procaine cardioplegic solution (St. Thomas', n = 13) was used. In the Bretschneider's group, marked changes in CBF occurred (p less than 0.001). Mean CBF was 27 (range 18 to 51) ml/(100 g X min) between sternotomy and the onset of extracorporeal circulation (ECC). A mean of 6 minutes after the onset of ECC, and before the administration of Bretschneider's cardioplegic solution, CBF increased to 39 ml/(100 g X min). After administration of the cardioplegic solution, CBF decreased significantly within the first 15 minutes, and then gradually increased to a mean of 68 (range 43 to 108) ml/(100 g X min). Cerebral blood flow was 45 ml/(100 g X min) just after ECC was stopped. Marked plasma procaine concentrations, up to 100 mg/l, were reached just after the infusion of Bretschneider's solution. The flow was significantly reduced (p less than 0.015) in patients with plasma procaine greater than or equal to 10 mg/l, when compared to patients with plasma procaine values less than 10 mg/l. In the St. Thomas' cardioplegic solution group the same reduction in CBF did not occur (p less than 0.02). Despite the depressant effect of procaine on CBF in the Bretschneider group, a consistent brain hyperperfusion was observed in all patients during hypothermic ECC if their blood pressure was sufficient to produce hyperemia. In rats (n = 6), during normothermia without extracorporeal circulation, the effect of procaine was much more pronounced. The CBF fell from a mean resting level of 108 ml/(100 g X min) to 68 and 54 ml/(100 g X min) after 15 and 35 minutes, respectively, of continuous infusion of Bretschneider's solution. The flow returned to the resting level about 40 minutes after termination of the infusion.

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Section: Resultsmentioning

confidence: 99%

Cerebral Blood Flow during Early Cardiopulmonary Bypass in Man. Effect of Procaine in Cardioplegic Solutions

Henriksen¹,

Di²,

Ih³

et al. 1986

Thorac cardiovasc Surg

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“…Since procaine hydrochloride is soluble in water, it can be administered in the blood stream. However, since the half‐life of procaine being only 36 seconds, it is immediately excreted in the urine. By adding a small amount of benzoic acid, the half‐life of procaine can be enhanced, thus repairing damaged cells.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensing of Anesthetics using Polythiophene Coated Glassy Carbon Electrodes

Ramkumar

Sangaranarayanan

2019

ChemistrySelect

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A novel electrochemical sensor for anesthetics employing the polymerization of Thiophene onto glassy carbon electrodes is demonstrated. The polymer was characterized by electrochemical and morphological characterizations using cyclic voltammetry, differential pulse voltammetry, Fourier transform infrared spectroscopy and scanning electron microscopy. This polythiophene modified electrode was employed for sensing anesthetics and a lowest detection limit of 35 nM, 50 nM and 20 nM were obtained for Procaine, Benzocaine and Procainamide respectively. The interference studies showed the selectivity of this electrode in the presence of common interfering agents. The Dopaminergic effect of Procaine is studied by varying concentrations of dopamine and a thorough study established the profound effect.

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Pharmacokinetic Model for Procaine in Humans during and following Intravenous Infusion

Smith

Hunt

Seifen

et al. 1979

Journal of Pharmaceutical Sciences

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Measurement of chloroprocaine and procaine in plasma by flame ionization gas-liquid chromatography.

Cited by 9 publications

References 4 publications

Cerebral Blood Flow during Early Cardiopulmonary Bypass in Man. Effect of Procaine in Cardioplegic Solutions

Cerebral Blood Flow during Early Cardiopulmonary Bypass in Man. Effect of Procaine in Cardioplegic Solutions

Electrochemical Sensing of Anesthetics using Polythiophene Coated Glassy Carbon Electrodes

Pharmacokinetic Model for Procaine in Humans during and following Intravenous Infusion

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