Measurement of calcium stable isotope tracers using cool plasma ICP-MS

Patterson, Kristine Y.; Veillon, Claude; Hill, A. David; Moser-Veillon, Phylis B.; O’Haver, T. C.

doi:10.1039/a900677j

Cited by 55 publications

(51 citation statements)

References 21 publications

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“…Calcium is normally susceptible to interferences when determined by quadrupole ICP-MS and was the element with the highest bias, 23%. 9 Due to the high background associated to sodium a bias of 15% was observed. The other elements have shown a bias lower than 10%.…”

Section: Resultsmentioning

confidence: 99%

Multi-site PM2.5 and PM2.5-10 aerosol source apportionment in Rio de Janeiro, Brazil

Soluri

Godoy

et al. 2007

J. Braz. Chem. Soc.

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Foi realizada a amostragem de aerossol em dez locais distribuídos em diferentes regiões da cidade do Rio de Janeiro, de setembro/2003 a setembro/2004, em uma base semanal com amostragens de 24 horas. As frações do aerossol PM 2.5 e PM 2.5-10 foram amostradas usando um sistema com filtros em série. Foram determinadas: a massa do aerossol, carbono elementar, a concentração dos íons solúveis, assim como a concentração total de alumínio, cálcio, ferro, magnésio, potássio, sódio e titânio. A concentração mássica média anual do PM 10 variou de 18 a 38 μg m -3 , sem violação dos padrões brasileiros de qualidade do ar. Para as frações fina e grossa, entre 70 e 90% da massa medida foi identificada como sendo devido à poucas fontes, sendo que a poeira do solo explica 37-63% da massa da fração grossa (PM 2.5-10 ). Por outro lado, o carbono elementar e o aerossol secundário representam proporções elevadas (45-58%) da massa da fração fina (PM 2.5 ).Aerosol sampling was performed at ten sites distributed in different location of Rio de Janeiro city, from September/2003 to Sepetember/2004, on a weekly basis with 24 h sampling time interval. PM 2.5 and PM 2.5-10 aerosol particles were sampled using Stacked Filter Units (SFU). Aerosol mass, black carbon, water soluble ions concentration as well as total aluminum, calcium, iron, magnesium, potassium, sodium and titanium concentration were determined. Mean annual PM 10 mass concentration ranged from 18 to 38 μg m -3 , without violation of the Brazilian air quality standards. For fine and coarse modes, between 70 and 90% of the measured mass was apportioned to relatively few sources, soil dust accounts for 37-63% of the coarse mode mass. On the other hand, black carbon and secondary aerosol, related to anthropogenic sources as fuel burning, represents very high proportions (45-58%) of the PM 2.5 mass.Keywords: Brazil, air pollution, aerosol, source apportionment IntroductionThe city of Rio de Janeiro is one of the twenty biggest urban agglomerations in the world, with 11 million inhabitants in the metropolitan area and the first, among the Brazilian cities, in respect to the population density, with 1700 hab/km 2 . 1,2 Among the metropolitans regions existing in the country, Rio de Janeiro has the highest degree of urbanization, 96.8%, and responds for 80% of the internal income of the State and 13% of the Country. 1,3 Factors such as local topography, irregular occupation of the space, presence of open sea and a fraction of the urban area at the Guanabara Bay influence the urban atmosphere of the city of Rio de Janeiro. These factors result in an efficient, however complex, regimen of atmospheric circulation, combining winds with the canalizations originated from its topography, and, consequently, contributing to an irregular distribution and dispersion of pollutants. The climatological evaluation of the atmospheric circulation in Rio de Janeiro shows that the highest wind direction frequency is from SouthSoutheast to Northeast sectors, along the year, with average wind velocity o...

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Section: Resultsmentioning

confidence: 99%

Multi-site PM2.5 and PM2.5-10 aerosol source apportionment in Rio de Janeiro, Brazil

Soluri

Godoy

et al. 2007

J. Braz. Chem. Soc.

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“…The sample matrix therefore has an influence on the observed mass bias and the correction procedures applied should be based on natural abundance isotope ratios of the element of interest determined in the sample matrix and not in aqueous standard solutions. Nevertheless, the most often used correction procedure is bracketing of samples with standards of known isotopic composition [41,49,57,58]; bracketing with "baseline" human samples taken before application of the enriched stable isotope is less often used [18]. One of the fundamental problems in choosing a mass-bias procedure is that the underlying physics is not fully understood.…”

Section: Accuracy and Precisionmentioning

confidence: 98%

“…This approach was applied by Patterson et al [41] who used cool plasma quadrupole ICPMS to measure calcium isotope ratios ( 42 Ca + / 43 Ca + and 44 Ca + / 43 Ca + ) in urine, feces, serum, and milk. Patterson reports that when using a plasma power of 650 W formation of doubly charged strontium ions (Sr 2+ interferes with 42 Ca + , 43 Ca + and 44 Ca + ) was completely eliminated and formation of 40 Ar 1 H 2 + and 12 C 16 O 2 + (which interfere with 42 Ca + and 44 Ca + ) were reduced to levels in which accurate and precise de- [41], comparable with that of high-resolution ICPMS [12,49] and surpassed only by that of TIMS [50,51] and multi-collector ICPMS [52].…”

Section: Quadrupole Icpmsmentioning

confidence: 99%

“…Although more infrequently than for zinc, quadrupole ICPMS methods have also been published for other elements with the purpose of being used in nutritional studies; examples include Ca [35,40,41,42], Fe [23,35,42,43], Cu [17,20,35], Mg [44], Mo [45,46,47], and Se [48]. The main limitation to the use of quadrupole ICPMS for these elements is the large number of polyatomic ion interferences and the difficulty of removing them while still leaving the 2 or 3 isotopes needed for analysis free from interferences.…”

Section: Quadrupole Icpmsmentioning

confidence: 99%

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The use of ICPMS for stable isotope tracer studies in humans: a review

St�rup

2004

Analytical and Bioanalytical Chemistry

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The use of stable isotope tracers in human studies is a rapidly growing research field that benefits from the many new developments in inorganic mass spectrometric instrumentation and from the better availability of mass spectrometric techniques to nutritional scientists during the last three decades. Traditionally, thermal ionization mass spectrometry (TIMS) has been the preferred technique for these studies, but the development of new inductively coupled plasma mass spectrometric (ICPMS) techniques with better isotope-ratio measurement and interference-removal capabilities (e.g. single and multi-detector ICPMS and reaction/collision cell ICPMS) has enabled broader use of ICPMS for determination of stable isotope tracers in nutritional research. This review discusses the current and future use of ICPMS in stable isotope tracer studies in humans.

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“…As a result of the respective ionization potentials, charge transfer from Ar + or Ar-containing ions to NO and O 2 molecules is a spontaneous reaction, leading to a reduction of the signal intensity of these ions by several orders of magnitude. Patterson et al, e.g., used cool plasma conditions to suppress the contributions from molecular ions such as ArH + 2 and CO + 2 , interfering with 42 Ca/ 43 Ca and 44 Ca/ 43 Ca isotope ratio determination in the Ca fractions, isolated from serum, urine, faeces, and breast milk by means of precipitation as oxalate [49]. Murphy et al used cool plasma conditions to enable isotopic analysis of K and Ca in biological samples after isolation of these elements from the matrix by means of cation exchange chromatography [50].…”

Section: Chemical Resolutionmentioning

confidence: 99%

Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP?mass spectrometry

Vanhaecke

Moëns

2004

Analytical and Bioanalytical Chemistry

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For isotope ratio applications where an internal isotope ratio precision >0.05-0.1% relative standard deviation suffices, single-collector inductively coupled plasma mass spectrometry (ICPMS) is fit-for-purpose, but for detecting more subtle variations in the natural isotopic composition of a target element, only multi-collector ICPMS (MC-ICPMS) can compete with thermal ionization mass spectrometry (TIMS). While as a result of the extensive sample preparation (analyte isolation) preceding TIMS and the "softer" ionization in vacuum, spectral interferences only seldom occur with this technique, their occurrence is recognized to be the most important drawback of ICPMS. This paper discusses high mass resolution and chemical resolution in a collision or dynamic reaction cell as powerful and versatile means to overcome spectral overlap and illustrates how their introduction has led to a substantial extension of the application range of ICPMS for isotope ratio applications. High mass resolution is the most elegant and straightforward way to overcome the problem of spectral overlap. Offering the possibility to operate the mass analyzer at a higher mass resolution, while at the same time preserving the flat-topped or trapezoidal peak shape required for highly precise isotope ratio measurements, was a challenge for the manufacturers of MC-ICPMS instrumentation. It will be discussed how these apparently contradicting requirements could be fulfilled simultaneously and an overview of the current situation will be given. Chemical resolution in a collision or dynamic reaction cell is an alternative to high mass resolution for overcoming spectral overlap. Real-life examples will be given to illustrate how also this approach can be used to advantage in isotope ratio work. Despite the greater flexibility and straightforwardness of high mass resolution, some situations will be discussed where chemical resolution is to be preferred. Finally, some desires as to future instrumentation are formulated.

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Measurement of calcium stable isotope tracers using cool plasma ICP-MS

Cited by 55 publications

References 21 publications

Multi-site PM2.5 and PM2.5-10 aerosol source apportionment in Rio de Janeiro, Brazil

Multi-site PM2.5 and PM2.5-10 aerosol source apportionment in Rio de Janeiro, Brazil

The use of ICPMS for stable isotope tracer studies in humans: a review

Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP?mass spectrometry

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