Measurement of brain glutamate using TE‐averaged PRESS at 3T

Hurd, Ralph E.; Sailasuta, Napapon; Srinivasan, Radhika; Vigneron, Daniel B.; Pelletier, Daniel; Nelson, Sarah J.

doi:10.1002/mrm.20007

Cited by 223 publications

(244 citation statements)

References 25 publications

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“…However, this is unlikely as at least the dorsal caudate of FEP showed higher Glu with no difference in NAA levels. Further studies using specific techniques to measure Glu, such as multiple echo times (Zhang et al, 2007), TE-averaged PRESS (Hurd et al, 2004), or constant time PRESS (Mayer and Spielman, 2005) are needed.…”

Section: Limitationsmentioning

confidence: 99%

Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis

Fuente‐Sandoval

León-Ortíz

Favila

et al. 2011

Neuropsychopharmacol

208

157

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The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological basis of the disease. The aim of this study was to compare, using proton magnetic resonance spectroscopy ( 1 H-MRS), glutamate levels in the precommissural dorsal-caudate (a dopamine-rich region) and the cerebellar cortex (negligible for dopamine) in the following: (1) 18 antipsychotic-naïve subjects with prodromal symptoms and considered to be at ultra high-risk for schizophrenia (UHR), (2) 18 antipsychotic-naïve first-episode psychosis patients (FEP), and (3) 40 age-and sex-matched healthy controls. All subjects underwent a 1 H-MRS study using a 3Tesla scanner. Glutamate levels were quantified and corrected for the proportion of cerebrospinal fluid and percentage of gray matter in the voxel. The UHR and FEP groups showed higher levels of glutamate than controls, without differences between UHR and FEP. In the cerebellum, no differences were seen between the three groups. The higher glutamate level in the precommissural dorsal-caudate and not in the cerebellum of UHR and FEP suggests that a high glutamate level (a) precedes the onset of schizophrenia, and (b) is present in a dopamine-rich region previously implicated in the pathophysiology of schizophrenia.

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Section: Limitationsmentioning

confidence: 99%

Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis

Fuente‐Sandoval

León-Ortíz

Favila

et al. 2011

Neuropsychopharmacol

208

157

View full text Add to dashboard Cite

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“…Due to the higher SNR and improved spectral separation at higher fields, an accurate and reproducible quantification of Glx becomes realistic. A recent study applying a TE-averaged PRESS technique at 3 T showed significantly increased Glutamate concentration in active lesions and also in the NAWM, suggesting that neuro-toxicity expressed by higher concentration of glutamate might play a substantial role in the inducement of axonal damage and therefore clinical disability [78,79].…”

Section: Quantitative Mri Methodsmentioning

confidence: 99%

High field MRI in the diagnosis of multiple sclerosis: high field–high yield?

Wattjes

Barkhof

2009

Neuroradiology

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Following the approval of the U.S. Food and Drug Administration (FDA), high field magnetic resonance imaging (MRI) has been increasingly incorporated into the clinical setting. Especially in the field of neuroimaging, the number of high field MRI applications has been increased dramatically. Taking advantage on increased signal-to-noise ratio (SNR) and chemical shift, higher magnetic field strengths offer new perspectives particularly in brain imaging and also challenges in terms of several technical and physical consequences. Over the past few years, many applications of high field MRI in patients with suspected and definite multiple sclerosis (MS) have been reported including conventional and quantitative MRI methods. Conventional pulse sequences at 3 T offers higher lesion detection rates when compared to 1.5 T, particularly in anatomic regions which are important for the diagnosis of patients with MS. MR spectroscopy at 3 T is characterized by an improved spectral resolution due to increased chemical shift allowing a better quantification of metabolites. It detects significant axonal damage already in patients presenting with clinically isolated syndromes and can quantify metabolites of special interest such as glutamate which is technically difficult to quantify at lower field strengths. Furthermore, the higher susceptibility and SNR offer advantages in the field of functional MRI and diffusion tensor imaging. The recently introduced new generation of ultra-high field systems beyond 3 T allows scanning in submillimeter resolution and gives new insights into in vivo MS pathology on MRI. The objectives of this article are to review the current knowledge and level of evidence concerning the application of high field MRI in MS and to give some ideas of research perspectives in the future.

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“…Two are examples of how to add a Carr-Purcell pulse train, and loop over either sequence timings or the number of pulses in the train. One generates basis functions for TE-averaged PRESS acquisitions [20], and four investigate corrections for PRESS acquisitions due to chemical shift artifacts caused by real RF localization pulses by including the effects of spatial variations of the B 1 profiles and a full simulation using complete user-defined time-domain RF pulse shapes [25]. The source code for all seven libraries serves as examples for how to create and integrate additional pulse sequences into the GAVA environment.…”

Section: New/addto Experiments Module (Spectral Simulations)mentioning

confidence: 99%

GAVA: Spectral simulation for in vivo MRS applications

Soher

Young

Bernstein

et al. 2007

Journal of Magnetic Resonance

109

102

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An application that provides a flexible and easy to use interface to the GAMMA spectral simulation package is described that is targeted at investigations using in vivo MR spectroscopic methods. The program makes available a number of widely used spatially-localized MRS pulse sequences and NMR parameters for commonly-observed tissue metabolites, enabling spectra to be simulated for any pulse sequence parameter and viewed in an integrated display. The application is interfaced with a database for storage of all simulation parameters and results of the simulations. This application provides a convenient method for generating a priori spectral information used in parametric spectral analyses and for visual examination of the effects of difference pulse sequences and parameter settings.

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Measurement of brain glutamate using TE‐averaged PRESS at 3T

Cited by 223 publications

References 25 publications

Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis

Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis

High field MRI in the diagnosis of multiple sclerosis: high field–high yield?

GAVA: Spectral simulation for in vivo MRS applications

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