Measurement of Amniochorionic Membrane Thickness Using High-Frequency Ultrasound

Frigo, Peter; Lang, C. Max; Golaszewski, Th.; Gruber, Denis; Berger, Angelika; Ulrich, R.; Eppel, Wolfgang; Huber, J.F.K.

doi:10.1002/(sici)1097-0223(199604)16:4<313::aid-pd849>3.0.co;2-0

Cited by 4 publications

(15 citation statements)

References 18 publications

(9 reference statements)

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“…No intra-observer variability or inter-observer variability data was included in this study. Similar to their other study, there was an increased thickness in the intermediary zone of the placental membrane [17, 18]. Distinct leukocyte infiltration of the entire amniochorionic membrane in patients with PPROM was noted on histologic preparation.…”

Section: Resultssupporting

confidence: 84%

“…Frigo and colleagues published a 1996 paper evaluating fetal membranes in vitro from 28 women who had normal term deliveries [17]. Measurements were carried out on a membrane specimen obtained 5–8 cm from the internal os.…”

Section: Resultsmentioning

confidence: 99%

“…The authors were able to visualize the amnion and chorion as echo-dense, the intermediary zone as echo-poor and inhomogeneous with the boundaries of each zone easily discernible. The authors indicated that the intermediary zone appeared to be primarily responsible for membrane thickness [17]. This intermediary zone lies between the amnion and chorion, and it allows membranes to absorb physical stress by providing a surface for which the amnion can slide on the chorion.…”

Section: Resultsmentioning

confidence: 99%

“…The first study by Frigo found that transabdominal ultrasound yielded in vitro measurements of membrane thickness that were similar to that of histological measurements [17]. The second study by Frigo found that in vitro fetal membrane thickness was significantly thinner in PROM patients with evidence of leukocyte infiltration and a thicker intermediary zone [18].…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, Basaran used a similar methodology with a much lower preterm birth rate of 6.8% and did not find a statistically significant difference between fetal membrane thickness in those who delivered preterm and those who delivered at term. [20] Frigo and colleagues found preterm birth associated with thinner fetal membranes with ex vivo ultrasound measurements, while the in vivo studies by Severi and colleagues had the opposite finding, albeit measuring thickness at different locations [17–20]. Basaran and colleagues note that a reason for the differing results of these two in vivo studies are that PPROM represents a final common pathway for a variety of etiological mechanisms.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions

Nunes

Cross

Speich

et al. 2016

BMC Pregnancy Childbirth

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BackgroundPreterm premature rupture of membranes (PPROM) is the largest identifiable cause of preterm birth. There is currently no good screening test for PPROM in low-risk asymptomatic patients. Our goal was to identify how imaging methods can be utilized for examining the risks for PPROM in asymptomatic patients.MethodsThis paper is a systematic review of the literature on fetal membrane thickness and its use for the prediction of PPROM. Four key studies are identified and reviewed; two in vitro studies and two in vivo ultrasound studies each using differing methodologies. Additionally reviewed is a study using Optical Coherence Tomography, an emerging technique using near-infrared technology to produce high-resolution images.ResultsThere is currently insufficient data to determine the association between fetal membrane thickness and PPROM by ultrasound.ConclusionsFetal membrane thickness could have relevant clinical ramifications for the prediction of PPROM. Suggested improvements in study methodology and design will lead to progress in this area of research, as well as the use of newer technologies. Larger sample sizes, histological comparison, uniform methodologies for data collection, longitudinal study design and expanding data analysis beyond fetal membrane thickness to other properties would expand our knowledge in this field. In addition, transvaginal ultrasound should be utilized to improve resolution, as well as emerging methodologies such as MRI fusion imaging using ultrasound and Shear Wave Elastography.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions

Nunes

Cross

Speich

et al. 2016

BMC Pregnancy Childbirth

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Membrane thickness and PROM—high-frequency ultrasound measurements

et al. 1998

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Premature rupture of the membranes (PROM) is still an unsolved problem in obstetrics. Neither prevention nor diagnosis nor therapy is readily available. The amniotic sac is stabilized mechanically by a dense network of collagenous fibres; in the event of PROM, the collagenous mesh is dissolved and the thickness of the amniotic sac is reduced. In a prospective study involving 32 patients, we measured the thickness of the membranes in vitro by high‐frequency ultrasound and by light microscopy of histological sections, between gestational weeks 28 and 32. We compared 18 patients with premature rupture of the amnio‐chorionic membrane with 14 patients following induction of labour, with intact membranes at the same gestational age in vitro. We were able to show that the membrane in the PROM group (0·54±0·9 mm) was markedly thinner with fewer collagenous fibres than in the control group (0·74±1·01 mm). The application of high‐frequency ultrasound in vivo in PROM may become helpful for the prediction of PROM; further studies are therefore desirable. © 1998 John Wiley & Sons, Ltd.

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Ultrasound and histological measurements of dividing membrane thickness in twin gestations

Bracero

Huff

Blitz

et al. 2017

Ultrasound in Obstet & Gyne

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Prenatal ultrasound measurement of twin dividing membrane thickness is positively correlated with postnatal histological measurement. Dichorionicity can be determined by a magnified dividing membrane thickness ≥ 1.9 mm. Measurements with the ultrasound beam parallel to the dividing membrane may be more accurate than perpendicular measurements. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.

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Measurement of Amniochorionic Membrane Thickness Using High-Frequency Ultrasound

Cited by 4 publications

References 18 publications

Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions

Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions

Membrane thickness and PROM—high-frequency ultrasound measurements

Ultrasound and histological measurements of dividing membrane thickness in twin gestations

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