Measurement of Adhesion Strength of Bonds Using Nonlinear Acoustics

Fassbender, S.; Arnold, W.

doi:10.1007/978-1-4613-0383-1_172

Cited by 17 publications

(5 citation statements)

References 7 publications

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“…The electrical current flowing through the resonator is a time derivative of the charge directly transduced from internal mechanical stresses. It is well-known that nonlinearity in mechanical stresses can be primarily dominated by interactions at the contact interface . Contact acoustic nonlinearity is, thus, widely used to characterize material defects. − This fundamental principle is the basis of ADT.…”

Section: Technique Descriptionmentioning

confidence: 99%

Anharmonic Surface Interactions for Biomolecular Screening and Characterization

2010

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The acoustic response of conventional mechanical oscillators, such as a piezoelectric crystal, is predominantly harmonic at modest amplitudes. However, here, we observe from the electrical response that significant motional anharmonicity is introduced in the presence of attached analyte. Experiments were conducted with streptavidin-coated polystyrene microbeads of various sizes attached to a quartz crystal resonator via specific and nonspecific molecular tethers in liquid. Quantitative analysis reveals that the deviation of odd Fourier harmonics of the response caused by introduction of microbeads as a function of oscillation amplitude presents a unique signature of the molecular tether. Hence, the described anharmonic detection technique (ADT) based on this function allows screening of biomolecules and provides an additional level of selectivity in receptor-based detection that is often associated with nonspecific interactions. We also propose methods to extract mechanical force-extension characteristics of the molecular tether and activation energy using this technique.

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Section: Technique Descriptionmentioning

confidence: 99%

Anharmonic Surface Interactions for Biomolecular Screening and Characterization

2010

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“…doi:10. 1016/j.ijsolstr.2005.11.006 of imperfect interfaces and cracks (Solodov et al, 1993;Hirose and Achenbach, 1993;Rudenko and Vu, 1994;Fassbender and Arnold, 1996;Nazarov and Sutin, 1997;Hirsekorn, 2001;Chen et al, 2001;Donskoy et al, 2001;Solodov and Korshak, 2002;Pecorari, 2003;Gusev et al, 2003;Biwa et al, 2004). Especially when a crack is closed, it may remain undetected by the linear ultrasonic techniques (Rokhlin and Kim, 2003) even though it can be excited ultrasonically to generate measurable second and higher order harmonic signals (Buck et al, 1978).…”

Section: Introductionmentioning

confidence: 95%

Hysteretic linear and nonlinear acoustic responses from pressed interfaces

Kim

Baltazar

et al. 2006

International Journal of Solids and Structures

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An analysis of the linear and nonlinear acoustic responses from an interface between rough surfaces in elastoplastic contact is presented as a model of the ultrasonic wave interactions with imperfect interfaces and closed cracks. A micromechanical elastoplastic contact model predicts the linear and second order interfacial stiffness from the topographic and mechanical properties of the contacting surfaces during a loading-unloading cycle. The effects of those surface properties on the linear and nonlinear reflection/transmission of elastic longitudinal waves are shown. The second order harmonic amplitudes of reflected/transmitted waves decrease by more than an order of magnitude during the transition from the elastic contact mode to the elastoplastic contact mode. It is observed that under specific loading histories the interface between smooth surfaces generates higher elastoplastic hysteresis in the interfacial stiffness and the acoustic nonlinearity than interfaces between rough surfaces. The results show that when plastic flow in the contacting asperities is significant, the acoustic nonlinearity is insensitive to the asperity peak distribution. A comparison with existing experimental data for the acoustic nonlinearity in the transmitted waves is also given with a discussion on its contact mechanical implication.

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“…The contributions to nonlinear output response from the contact interfaces is often significantly higher than that from the bulk at modest drive amplitudes so that intrinsic material nonlinearity can be neglected . Acoustic nonlinearity at the contact interfaces is, thus, widely used to characterize material defects. − In this method, the nonlinearity in the interaction forces at the biological interface transduced into an electrical signal is used for detection of surface-bound species.…”

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confidence: 99%

Anharmonic Interaction Signals for Acoustic Detection of Analyte

2010

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The challenges with frequency-based acoustic detection systems in sensitive, selective, and reliable quantitative estimation of surface-bound analyte are well-known. These systems are traditionally used in their linear incarnations; i.e., the measurement frequency is the same as the driving frequency. However, it was found in this work that interactions of adsorbents with sensor surface show significant anharmonicity even at low drive amplitudes. In particular, using streptavidin-coated polystyrene microbeads on an oscillating quartz surface in air, it has been demonstrated through modeling and experiments that the anharmonic signal from microparticle to surface interaction is significantly higher relative to that from bare quartz and orders of magnitude higher than relative shifts in resonant frequency. The signal is proportional to the number of microparticles and holds a well-defined functional relationship with the amplitude of oscillation, distinct to the nature of interaction with the surface for a given analyte. This approach, thus, can be used for ultrasensitive and quantitative detection of surface adsorbents and characterization of different kinds of surface interactions, distinguishing specific from nonspecific adsorbents. The modeling also reveals a direct functional relationship between the measured anharmonic signal and the interaction potential of the adsorbent with the surface.

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Measurement of Adhesion Strength of Bonds Using Nonlinear Acoustics

Cited by 17 publications

References 7 publications

Anharmonic Surface Interactions for Biomolecular Screening and Characterization

Anharmonic Surface Interactions for Biomolecular Screening and Characterization

Hysteretic linear and nonlinear acoustic responses from pressed interfaces

Anharmonic Interaction Signals for Acoustic Detection of Analyte

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