Measurement, correlation and thermodynamics of solubility of metronidazole in 2-(2-ethoxyethoxy)ethanol+water cosolvent mixtures at (298.15 to 333.15)K

Shakeel, Faiyaz; Haq, Nazrul; Alanazi, Fars K.

doi:10.1016/j.molliq.2014.11.008

Cited by 13 publications

(3 citation statements)

References 25 publications

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“…The relationship between solubility and temperature could be expressed as follows ln nobreak0em0.25em⁡ x 1 = A 0 + B 0 T + C 0 nobreak0em0.1em⁡ ln nobreak0em0.25em⁡ T where T is the absolute temperature (K). A 0 , B 0 , and C 0 represent the empirical model parameters of the equation, , and these parameters can be calculated by the multiple linear regression method. Average relative deviation (ARD) and root-mean-square deviations (RMSDs) are adopted to assess model accuracies and are expressed as eqs and …”

Section: Solubility and Model Calculationmentioning

confidence: 99%

“…The relationship between solubility and temperature could be expressed as follows where T is the absolute temperature (K). A 0 , B 0 , and C 0 represent the empirical model parameters of the equation, , and these parameters can be calculated by the multiple linear regression method. Average relative deviation (ARD) and root-mean-square deviations (RMSDs) are adopted to assess model accuracies and are expressed as eqs and …”

Section: Solubility and Model Calculationmentioning

confidence: 99%

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Solubility Determination and Thermodynamic Modeling of L-Phenylalanine in 12 Monosolvents from 283.15 to 323.15 K

Zhang,

Liu,

Wang

et al. 2024

J. Chem. Eng. Data

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The L-phenylalanine solubilities in 12 pure solvents (water, ethanol, methanol, n-propanol, isopropanol, n-butanol, isobutanol, acetonitrile, 1,4-dioxane, acetone, methyl acetate, and ethyl acetate) were measured from 283.15 to 325.15 K at 101.2 kPa. The results indicated that the L-phenylalanine solubility increased with temperature. Powder X-ray diffraction pattern (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) were used to identify and characterize the equilibrated solid-phase samples. The solubility behavior and the solute–solvent interaction of L-phenylalanine in each selected monosolvent were explored by the empirical solvents’ polarity parameter (E T(30)), hydrogen bonding, cohesive energy density, molecular structure, viscosity, and Hansen solubility parameters (HSPs). To extend the application range of the results, the experimental solubility data were correlated to the modified Apelblat model and the Yaws model. According to the Akaike Information Criterion (AIC), the modified Apelblat model was found to be better for the correlation of the L-phenylalanine solubility.

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Section: Solubility and Model Calculationmentioning

confidence: 99%

Section: Solubility and Model Calculationmentioning

confidence: 99%

Solubility Determination and Thermodynamic Modeling of L-Phenylalanine in 12 Monosolvents from 283.15 to 323.15 K

Zhang,

Liu,

Wang

et al. 2024

J. Chem. Eng. Data

View full text Add to dashboard Cite

show abstract

“…The mathematical expression is shown in eq . where T is the absolute temperature (K). A 1 , B 1 , and C 1 represent the empirical model parameters band of the modified Apelblat equation, , and these parameters can be calculated according to the nonlinear regression analysis method.…”

Section: Thermodynamic Modelsmentioning

confidence: 99%

Solubility of Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine in 12 Pure Organic Solvents from 298.15 to 358.15 K

Wang

Chen

et al. 2020

J. Chem. Eng. Data

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The solubility of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) in 12 pure solvents was measured in the temperature range of 298.15–358.15 K by the static equilibrium method through high-performance liquid chromatography (HPLC) at the atmospheric pressure, including dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), N,N-dimethylformamide (DMAC), 1,4-butyrolactone (BL), triethyl phosphate, propylene carbonate, N,N-dimethylformamide (DMF), cyclohexanone, cyclopentanone, acetonitrile, acetone, and pyridine. The experimental solubility data were correlated with three thermodynamic models, including the modified Apelblat model, the Yaws model, and the ideal solution model. Experimental data indicate that the solubility of HMX increases with increasing temperature in all test solvents, and three kinds of thermodynamic models gave satisfactory correlations. All of these results lay the foundation for the crystallization process study of HMX and provide guidance for the use of suitable crystallization methods in different solvents.

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Application of diethylene glycol monoethyl ether in solubilization of poorly water-soluble drugs

Lee

Choi

et al. 2019

J. Pharm. Investig.

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Measurement, correlation and thermodynamics of solubility of metronidazole in 2-(2-ethoxyethoxy)ethanol+water cosolvent mixtures at (298.15 to 333.15)K

Cited by 13 publications

References 25 publications

Solubility Determination and Thermodynamic Modeling of L-Phenylalanine in 12 Monosolvents from 283.15 to 323.15 K

Solubility Determination and Thermodynamic Modeling of L-Phenylalanine in 12 Monosolvents from 283.15 to 323.15 K

Solubility of Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine in 12 Pure Organic Solvents from 298.15 to 358.15 K

Application of diethylene glycol monoethyl ether in solubilization of poorly water-soluble drugs

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