Measurement and Correlation of the Solubility of Florfenicol Form A in Several Pure and Binary Solvents

Abstract

The solubility of florfenicol form A in eight pure organic solvents (propionic acid, ethanol, 1-propanol, 1-butanol, 2-propanol, 2-methyl-1-propanol, 3-methyl-1-butanol, and 2-ethyl-1-hexanol) and three binary solvents (dimethyl sulfoxide + ethanol, dimethyl sulfoxide + 1-propanol, and dimethyl sulfoxide + 1-butanol) was measured by a laser dynamic method at temperature from 283.15 to 323.15 K. The experimental results show that the mole fraction solubility of florfenicol in the pure solvents decreased according to the following order: ethanolThe experimental results show that the mole fraction solubility of florfenicol form A in the binary solvents increased with the increase of temperature and dimethyl sulfoxide mass fraction. The experimental solubility data were well correlated with the four thermodynamic models: modified Apelblat equation, λh equation, NRTL model equation, and Wilson model equation. The modified Apelblat model equation was regarded as the best one to fit the experimental values in the pure solvents.

Solid–Liquid Equilibrium Measurements for Posaconazole and Voriconazole in Several Solvents between T = 278.2 and 323.2 K Using Differential Thermal Analysis/Thermal Gravimetric Analysis

“…The modified Apelblat equation is often preferred for the direct empirical correlation of T – x solid–liquid equilibrium data in place of eq , which employs correlation via activity coefficients. This is because it has provided excellent fitting results for numerous solution systems in low solubility ranges as shown in recent studies. − It is useful for the correlation of SLE data as precise interpolation to different solubility temperatures can be easily achieved within the experimental range.…”

“…The equilibration measurement procedure has been applied before in the literature − and has been verified in previous works. − To confirm the procedures used for the binary solubility data, a test measurement for the benzoic acid (1) + water (2) system was conducted and compared to literature data. This is shown in Figure .…”

Measurement and Modeling of the Solubility of N,N-Dibenzylhydroxylamine in 17 Solvents from T = 273.15 to 323.35 K and Thermodynamic Properties of Solution

“…The Wilson model is based on the local composition concept and used to correlate the activity coefficient of solute in solvents. The model is given by eqs – − where γ 1 and γ 2 are the activity coefficients of solute and solvent, respectively; V 1 and V 2 represent the molar volume of solute and solvent, respectively, which can be calculated by eq with mole mass ( M ) and density (ρ); and Δλ 12 and Δλ 21 are two energy parameters regarding cross-interactions between the solute and solvent, respectively.…”

Solubility Measurement and Phase Equilibrium Modeling of 2-Aminobenzamide in 15 Pure Solvents

“…In the monosolvent system, the Wilson model is an expression of the activity coefficient and used to calculate the activity coefficient of the solute in the solvent. The model is given by eqs – − γ 1 and γ 2 are the activity coefficients of the solute and the solvent. V 1 and V 2 represent the molar volume of 2-AB and the solvent, respectively.…”