Measurement and Correlation of the Solubility of 2-Mercapto-1,3,4-thiadiazol in Aqueous Binary Solvent Mixtures

Ma, Yuanchang; Gao, Yun-Long; Gao, Xujie; Wang, Zi-Hao; Feng, Weichun; Xing, Wenguo; Li, Hongcheng; Yu, Shaoming

doi:10.1021/acs.jced.1c00970

Cited by 5 publications

(2 citation statements)

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“…The Sun model is used to correlate the solubility data at different temperatures and different compositions of mixed solvents, which can be described as follows 20 where x 1 , x 2 0 , and x 3 0 are the mole fractions of solute, good solvent, and antisolvent, respectively; T is the absolute temperature; N is the number of the solvents, which is equal to two for a binary solvent mixture; and J i constitutes the model parameters. When combined with the modified Apelblat model, the modified Jouyban−Acree model can be obtained and expressed as follows 23 = + where A 1 to A 9 are the final model parameters.…”

Section: Sun Modelmentioning

confidence: 99%

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Solubility Measurement and Correlation of Itraconazole Hydroxy Isobutyltriazolone in Four Kinds of Binary Solvent Mixtures with Temperature from 283.15 to 323.15 K

Dong,

Yu,

Wang

et al. 2023

ACS Omega

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The solubility of itraconazole hydroxy isobutyltriazolone (IHI) in four commonly used binary solvent mixtures of N,N-dimethylformamide (DMF) + water, DMF + ethanol, tetrahydrofuran (THF) + water, and THF + ethanol was determined with gravimetric method at temperatures ranging from 283.15 to 323.15 K under atmospheric pressure. The solubility of IHI in all selected solvents increases with the increase of temperature. The maximum solubility of IHI exists in the solvent of DMF + ethanol (0.06523 mol·mol–1, x 2 0 = 0.7, T = 323.15 K), while the minimum solubility exists in DMF + water (0.0003723 mol·mol–1, x 2 0 = 0.3, T = 283.15 K). There is a co-solvency phenomenon in the mixed solvents of DMF+ ethanol, THF + water, and THF + ethanol. Four thermodynamic models, including the modified Apelblat model, the Yaws model, the Sun model, and the modified Jouyban–Acree model, were selected to fit the solubility data of IHI. All the RAD values are less than 0.0484, and RMSD values are not more than 0.001319. The Yaws model and the modified Apelblat model fit the solubility data of IHI better than the other two models. All the selected four models can fit the solubility data of IHI well.

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Section: Sun Modelmentioning

confidence: 99%

“…The Sun model is used to correlate the solubility data at different temperatures and different compositions of mixed solvents, which can be described as follows 20 where D 1 to D 7 are the model parameters.…”

Section: Theoretical Modelsmentioning

confidence: 99%