Measles Virus Infection and Subacute Sclerosing Panencephalitis

Anlar, Banu; Yalaz, Kalbiye

doi:10.1007/978-3-0348-0425-7_1

Cited by 5 publications

(11 citation statements)

References 68 publications

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“…MSCs are immunomodulatory or immunosuppressive in vivo and in vitro: they can induce or prevent differentiation and immunoglobulin secretion of B cells depending on experimental conditions . Measles Immunoglobulin G titers or synthesis index do not correlate with clinical state in SSPE . Hypothetically, the highly active intrathecal immunoglobulin synthesis of patients with SSPE may not be overcome by MSC application.…”

Section: Discussionmentioning

confidence: 99%

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Mesenchymal stem cell application in children with subacute sclerosing panencephalitis

Kuşkonmaz

Uçkan

Yalnızoğlu

et al. 2015

Develop Med Child Neuro

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Subacute sclerosing panencephalitis (SSPE) is a serious, often fatal disease that responds poorly to current treatment modalities. Recently, the ability of mesenchymal stem cells (MSCs) to produce neurotrophic factors and inflammatory molecules has placed them among potential treatment agents for neurological conditions. We report the results of four patients treated with MSC for SSPE. The patients were followed up clinically, and by periodical laboratory evaluations, magnetic resonance imaging (MRI), and electroencephalography. One patient deteriorated to stage III of the disease, two patients remained in the same stage, and one died from disease progression and respiratory problems. Neurological findings and electroencephalography scores were consistent with the clinical course of the patient whereas MRI showed new inflammatory lesions in two patients. This is the first report of the application of MSC in SSPE. No benefit is demonstrated.

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Section: Discussionmentioning

confidence: 99%

“…Subacute sclerosing panencephalitis (SSPE) is a chronic disorder caused by persistent measles virus . Treatment options are scarce, and results, variable.…”

mentioning

confidence: 99%

Mesenchymal stem cell application in children with subacute sclerosing panencephalitis

Kuşkonmaz

Uçkan

Yalnızoğlu

et al. 2015

Develop Med Child Neuro

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“…35 Alternatively vaccine failure has been reported in a small number of patients, who were typically immunised before 12 months of age and did not seroconvert. 37 Subacute sclerosing panencephalitis during pregnancy is very rare. Our review of the scientifi c literature yielded 21 prior cases (table 2).…”

Section: Grand Roundmentioning

confidence: 99%

“…37,54 Cerebrospinal fl uid analysis for both anti-measles virus IgG titres and intrathecal synthesis of virus-specifi c IgG index is diagnostic for subacute sclerosing panencephalitis. 37,54 Intrathecal synthesised IgG is typically markedly elevated with oligoclonal bands; however, IgG might not be solely specifi c for measles virus but to other viruses at lower titres. Detection of anti-measles IgM in cerebrospinal fl uid has been suggested to lead to an extended course of subacute sclerosing panencephalitis.…”

Section: Grand Roundmentioning

confidence: 99%

“…Measles RNA is rarely identifi ed, but it is diagnostic for subacute sclerosing panencephalitis. 37,54 Investigators of one study 55 found that patients with the disease had cerebrospinal fl uid-to-serum ratios between 1:80 and 1:5. This represents the antibody index, which calculates the cerebrospinal fl uid-to-serum antibody ratio that could diff erentiate between blood-derived and brain-derived pathogenesis.…”

Section: Grand Roundmentioning

confidence: 99%

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Subacute sclerosing panencephalitis in pregnancy

Chiu

Meatherall

Nikolić

et al. 2016

The Lancet Infectious Diseases

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We present a case of subacute sclerosing panencephalitis that developed in a previously healthy 29-year-old pregnant woman who had returned from a trip to rural India shortly before the onset of symptoms. She was admitted to hospital at 27 weeks' gestation with a history of cognitive decline and difficulty completing simple tasks. She had no clinical signs of infection. The working diagnosis was autoimmune encephalitis, although extensive investigations did not lead to a final classifying diagnosis. The patient became comatose and developed hypertension, and an emergency caesarean section was done at 31 weeks to deliver the child, who seemed healthy. The patient died about 6 weeks after the onset of symptoms. The patient was found to have had subacute sclerosing panencephalitis at autopsy. In this Grand Round, we review the clinical features and treatment of subacute sclerosing panencephalitis, and the epidemiological and public health aspects of the case.

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Modulation of immune responses in the central nervous system by Zika virus, West Nile virus, and dengue virus

Wu,

Zhang,

Qiang

et al. 2024

Reviews in Medical Virology

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Arthropod‐borne viruses (arboviruses) pose significant threats to global public health by causing a spectrum of diseases ranging from mild febrile illnesses to severe neurological complications. Understanding the intricate interplay between arboviruses and the immune system within the central nervous system is crucial for developing effective strategies to combat these infections and mitigate their neurological sequelae. This review comprehensively explores the mechanisms by which arboviruses such as Zika virus, West Nile virus, and Dengue virus manipulate immune responses within the CNS, leading to diverse clinical manifestations.

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Measles Virus Infection and Subacute Sclerosing Panencephalitis

Cited by 5 publications

References 68 publications

Mesenchymal stem cell application in children with subacute sclerosing panencephalitis

Mesenchymal stem cell application in children with subacute sclerosing panencephalitis

Subacute sclerosing panencephalitis in pregnancy

Modulation of immune responses in the central nervous system by Zika virus, West Nile virus, and dengue virus

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