Measles Reimmunization in Children Immunized Before 1 Year of Age

Lampe, Richard M.

doi:10.1001/archpedi.1985.02140030035022

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…Our results agree with those reported for similar studies [5]. The significant difference between the measles antibody levels of mothers and children (even when reimmunized) may be due to a natural immunity acquired by the mothers and the lower antigenicity of the Schwartz vaccine [9].…”

Section: Discussionsupporting

confidence: 92%

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Follow-Up Study for Measles Maternal Antibodies and Seroconversion after Measles Vaccination

Abanamy¹,

Khalil²,

Salman³

et al. 1991

Ann Saudi Med

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Seventy-two children were included in this study which examined measles maternal antibodies in children at the ages of six and nine months. The seroconversion after the first measles vaccination at nine months and revaccination at fifteen months was also evaluated. Results of testing were negative in 33% of the children at six months and in 36% at nine months, indicating continued susceptibility to measles. No significant difference was found in the measles IgG level between six and nine months of age. After the initial vaccination at nine months of age, the seroconversion rate was 85%. After revaccination at fifteen months of age, the children showed a significant increase in their measles IgG levels. The persistence of maternal antibodies is the important cause of the primary vaccine failure observed in infants younger than twelve months [1][2][3]. The optimal age of vaccination remains controversial, and varies in different areas. Seroconversion studies in different populations can be done to determine the earliest age for effective vaccination [4]. Alternatively, a seroprevalence study can be carried out in young infants to determine when maternal antibodies are waning.This study aims to evaluate measles maternal antibodies in children at six and nine months of age and their relationship to the mothers' measles antibody level in order to determine the earliest possible age of vaccination, the seroconversion rate after measles vaccination at the age of nine months, and the effect of revaccination at fifteen months of age. Material and MethodsSeventy-two healthy children, who were referred from primary health care centers and who had normal growth parameters and no history of chronic illness at the age of six months, were included in the study. They were followed through four visits, and at each, a special form was filled out. The first visit was made at six months, and blood samples for measles antibodies were taken from the mother and child. At the second visit, when the infant was nine months old, additional blood samples were taken and the child vaccinated (Schwartz vaccine; Rouvax Biomerieux). The third visit was scheduled when the child was fifteen months old. At that time a third blood sample was taken and an MMR vaccine given (Merck, Sharp, and Dohme). The fourth visit was scheduled two weeks following the MMR vaccination.Twenty-one children had four samples taken. The vaccines were tested for potency using TCID50 (tissue culture infective dose 50%). The end titer in Vero cells was determined using growth and maintenance media (Earl's

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Section: Discussionsupporting

confidence: 92%

“…The reciprocal values of fluorescent IgG titers were converted to a logarithm and examined using a paired t test [5]. The geometric mean of the titer (GMT) was computed to quantitatively compare the measles-specific antibodies at various ages.…”

Section: Methodsmentioning

confidence: 99%

Follow-Up Study for Measles Maternal Antibodies and Seroconversion after Measles Vaccination

Abanamy¹,

Khalil²,

Salman³

et al. 1991

Ann Saudi Med

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“…Although this latter regimen avoided the side effects of the live vaccine series, it also was less effective. Recipients not only had immunity of shorter duration but were at risk for atypical measles infection 6 . Notably, whereas the live vaccine induces cell-mediated immunity, the inactivated vaccine does not.…”

Section: Selection Of Vaccine Type: Convenience or Efficacy?mentioning

confidence: 99%

Can successful vaccines teach us how to induce efficient protective immune responses?

Lambert

Liu

Siegrist

2005

Nat Med

173

102

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Some recently introduced vaccines that have excellent efficacy records have been developed without a clear understanding of their mechanism of protection. In fact, successful vaccines have often emerged out of empirical observations and have only rarely been the result of a rational use of the continuously increasing immunological knowledge available to scientists. However, a posteriori deciphering of the biological bases for the efficacy of successful vaccines should be an essential component of research efforts directed at the development of new vaccines for the most challenging infectious diseases.

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“…No entanto, trabalhos posteriores demonstraram claramente que a vacinação aos 9 meses de idade não altera a imunidade conferida pela vacina ou por reforços posteriores [51][52][53][54][55][56] .…”

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Comparison of seroconversion rates between well-nourished and malnourished children after measles immunization at nine months of age

Mj¹,

Mm²,

Sp³

et al. 1996

J Pediatr (Rio J)

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311 Resumo AbstractThe study was based on activities developed at Embu, SP, between October 1989 and June 1990. Its purpose was to study serological turning after child vaccination against measles at the age of nine months. Two groups were compared, both within the same age limits. Group number I included eutrophic children and group number II included undernourished children. Gomes criteria was used to evaluate the children's nutritional state.Antibodies (AB) dosage was done through hemagglutination inhibition (HI) and ELISA. These two laboratory methods were also checked regarding its sensibility.Out of 130 children studied, 80 could be evaluated. From this total, 56 (70%) belonged to group I and 24 (30%) belonged to group II.When the ELISA method was used, a significantly higher seroconversion percentage (P < 0,05 or 5%) was found among children belonging to group II. This percentage was not detected when the HI method was used.J. pediatr. (Rio J.). 1996; 72(5):311-318: vaccine, measles, malnutrition, seroconversion. Viragem sorológica após a vacinação contra o sarampo, realizada em crianças eutróficas e desnutridas, aos nove meses de idade Comparison of seroconversion rates between well-nourished and malnourished children after measles immunization at nine months of age

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Measles Reimmunization in Children Immunized Before 1 Year of Age

Cited by 5 publications

References 3 publications

Follow-Up Study for Measles Maternal Antibodies and Seroconversion after Measles Vaccination

Follow-Up Study for Measles Maternal Antibodies and Seroconversion after Measles Vaccination

Can successful vaccines teach us how to induce efficient protective immune responses?

Comparison of seroconversion rates between well-nourished and malnourished children after measles immunization at nine months of age

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