Measles in Minsk, Belarus, 2001–2003: Clinical, virological and serological parameters

Atrasheuskaya, Alena; Blatun, E.M.; Неверов, А. А.; Kameneva, S.N.; Максимов, Н. Л.; Karpov, Igor; Ignatyev, G. M.

doi:10.1016/j.jcv.2004.11.024

Cited by 18 publications

(13 citation statements)

References 24 publications

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“…Traditionally, measles IgG avidity assays have been used to classify primary (PVF) and secondary (SVF) vaccine failures (2,16,31,33). PVF are vaccinated individuals who never responded to the vaccine and present with classic measles upon measles virus infection.…”

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confidence: 99%

Measles Virus IgG Avidity Assay for Use in Classification of Measles Vaccine Failure in Measles Elimination Settings

Mercader¹,

Garcia²,

Bellini³

2012

Clin. Vaccine Immunol.

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In regions where endemic measles virus has been eliminated, diagnostic assays are needed to assist in correctly classifying measles cases irrespective of vaccination status. A measles IgG avidity assay was configured using a commercially available measlesspecific IgG enzyme immunoassay by modifying the protocol to include three 5-min washes with diethylamine (60 mM; pH 10.25) following serum incubation; serum was serially diluted, and the results were expressed as the end titer avidity index. Receiver operating characteristic analysis was used for evaluation and validation and to establish low (<30%) and high (>70%) end titer avidity thresholds. Analysis of 319 serum specimens expected to contain either high-or low-avidity antibodies according to clinical and epidemiological data indicated that the assay is highly accurate, with an area under the curve of 0.998 (95% confidence interval [CI], 0.978 to 1.000), sensitivity of 91.9% (95% CI, 83.2% to 97.0%), and specificity of 98.4% (95% CI, 91.6% to 100%). The assay is rapid (<2 h) and precise (standard deviation [SD], 4% to 7%). In 18 samples from an elimination setting outbreak, the assay identified 2 acute measles cases with low-avidity results; both were IgM-positive samples. Additionally, 11 patients (15 samples) with modified measles who were found to have high-avidity IgG results were classified as secondary vaccine failures; one sample with an intermediate-avidity result was not interpretable. In elimination settings, measles IgG avidity assays can complement existing diagnostic tools in confirming unvaccinated acute cases and, in conjunction with adequate clinical and epidemiologic investigation, aid in the classification of vaccine failure cases.

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confidence: 99%

Measles Virus IgG Avidity Assay for Use in Classification of Measles Vaccine Failure in Measles Elimination Settings

Mercader¹,

Garcia²,

Bellini³

2012

Clin. Vaccine Immunol.

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“…In a study from Minsk, only 21.4% (3/14) of adult patients demonstrated severe measles symptoms (Atrasheuskaya et al, 2005). The patients' age in that study ranged from 15 to 25 years and; 11/14 patients had a history of prior measles vaccination.…”

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confidence: 89%

Clinical and genetic characterization of measles viruses isolated from adult patients in Shanghai in 2006

Qian

Sheng

et al. 2007

Journal of Clinical Virology

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“…To the best of our knowledge, since 80’, no case of atypical measles syndrome has been reported in the literature. In contrast, non-classical measles that is characterised by a mild clinical presentation has been reported during outbreaks as a diagnosis challenge, mostly in vaccinated patients 13 14. Currently, the live-attenuated and combined measles-mumps-rubella (MMR) vaccine is used and recommended since 1985 in Europe and the USA 1 3.…”

Section: Discussionmentioning

confidence: 99%

Atypical measles syndrome in adults: still around

et al. 2015

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Measles, a vaccine-preventable disease, is currently responsible for worldwide outbreaks mainly due to the failure to maintain high coverage of childhood immunisation. Atypical measles syndrome was first described in the 1960s in association with the inactivated measles vaccine. We report a case of atypical measles syndrome in a 29-year-old man without previous measles immunisation. He presented with fever, shortness of breath and a purpuric rash. Radiological investigations allowed the diagnosis of severe nodular pneumonia. Positive PCR in nasal and pharyngeal samples, and positive serology for a primary infection confirmed measles diagnosis. Both clinical symptoms and pulmonary nodules regressed spontaneously, whereas mediastinal lymph nodes increased and persisted up to 3 months after the primary infection. Physicians should be aware of the atypical measles syndrome presentation in order to limit the delay of diagnosis, to avoid unnecessary investigations and to prevent the potential spread of this infectious disease.

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Measles in Minsk, Belarus, 2001–2003: Clinical, virological and serological parameters

Cited by 18 publications

References 24 publications

Measles Virus IgG Avidity Assay for Use in Classification of Measles Vaccine Failure in Measles Elimination Settings

Measles Virus IgG Avidity Assay for Use in Classification of Measles Vaccine Failure in Measles Elimination Settings

Clinical and genetic characterization of measles viruses isolated from adult patients in Shanghai in 2006

Atypical measles syndrome in adults: still around

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