Measles IgM response during reinfection of previously vaccinated children

The changing epidemiology of hospitalized pediatric patients in three measles outbreaks

“…17 The anti-measles IgM antibody has been studied for determining the vaccine failures. A positive anti-measles IgM has been regarded as an indication of primary vaccine failure in some studies, 10,11,18 although there is some controversy. 17,19 In addition, the vaccinees who subsequently develop measles have been reported to have a milder illness than the non-vaccinees in some studies, 20,21 whereas other studies reported that there were no differences for clinical illness between the two groups.…”

Measles Vaccine Failure

“…The single patient who was vaccinated when older than fifteen months and who had no IgM antibody response had been immunized since the age of 4 years and 10 months. This probably represents a secondary vaccine failure [7,8]. Our study therefore shows that the main cause of vaccine failure is primary failure due to persistent maternal antibodies and cold chain defect.…”

“…In secondary vaccine failure, clinically apparent infection develops despite an immune response to vaccination [7][8][9]. However, this elicited response may not be adequate to protect against the subsequent inoculum of wild-type virus, or an initially protective response may wane over time.…”

Antibody Responses In Bangladeshi Children Following Measles Vaccination.

“…Persons who have experienced an initial antigenic stimulation from either natural measles or vaccines generally exhibit an anamnestic or secondary response after either vaccination or exposure to natural measles. 8 This secondary response is characterized by rapid and often transient increase in IgG antibody. 9 Though measles has been targeted for global eradication but currently, there is insufficient data from Bangladesh regarding the antibody responses in children following measles vaccination.…”