Measles Elimination in the Americas: A Comparison Between Countries With a One-Dose and Two-Dose Routine Vaccination Schedule

Sever, Adrianne; Rainey, Jeanette J.; Zell, Elizabeth R.; Hennessey, Karen; Uzicanin, Amra; Castillo‐Solórzano, Carlos; Dietz, Vance

doi:10.1093/infdis/jir445

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…The age for the second dose varies across countries: the second dose is either administrated few months apart from the first dose (e.g., France, Austria, Germany, Brazil, Australia) or a few years apart (e.g., USA, UK, Italy, Sweden, Finland), around the age of school enrollment [51,53,54]. The implementation of measles vaccination programs has led in many settings to the elimination of endemic transmission of measles, at least temporarily [51,55,56], even before adopting routine two-dose schedules [57].…”

Section: Application To Measlesmentioning

confidence: 99%

“…Our theoretical findings offer insight on vaccine parameters when the epidemic was eliminated at least temporarily through voluntary vaccination. We consider countries where measles vaccination programs have led to the elimination of measles using a one-dose routine vaccination schedule (e.g., some countries in the Americas [57]) or two doses administered in a relatively short period of time (e.g., Australia [56]). In this case, according to Eq.…”

Section: Application To Measlesmentioning

confidence: 99%

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Prevention of treatable infectious diseases: A game-theoretic approach

Jijón¹,

Breban²

2017

Vaccine

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We model outcomes of voluntary prevention using an imperfect vaccine, which confers protection only to a fraction of vaccinees for a limited duration. Our mathematical model combines a single-player game for the individual-level decision to get vaccinated, and a compartmental model for the epidemic dynamics. Mathematical analysis yields a characterization for the effective vaccination coverage, as a function of the relative cost of prevention versus treatment; note that cost may involve monetary as well as non-monetary aspects. Three behaviors are possible. First, the relative cost may be too high, so individuals do not get vaccinated. Second, the relative cost may be moderate, such that some individuals get vaccinated and voluntary vaccination alleviates the epidemic. In this case, the vaccination coverage grows steadily with decreasing relative cost of vaccination versus treatment. Unlike previous studies, we find a third case where relative cost is sufficiently low so epidemics may be averted through the use of prevention, even for an imperfect vaccine. However, we also found that disease elimination is only temporary-as no equilibrium exists for the individual strategy in this third case-and, with increasing perceived cost of vaccination versus treatment, the situation may be reversed toward the epidemic edge, where the effective reproductive number is 1. Thus, maintaining relative cost sufficiently low will be the main challenge to maintain disease elimination. Furthermore, our model offers insight on vaccine parameters, which are otherwise difficult to estimate. We apply our findings to the epidemiology of measles.

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Section: Application To Measlesmentioning

confidence: 99%

Section: Application To Measlesmentioning

confidence: 99%

Prevention of treatable infectious diseases: A game-theoretic approach

Jijón¹,

Breban²

2017

Vaccine

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“…Measles transmission was "effectively eliminated" in the United States and Canada around 1998 [1] and post-elimination surveillance was elegantly reviewed by Fiebelkorn Parker and colleagues [2]. However, the Centers for Disease Control and Prevention (CDC) reported 222 cases of measles and 17 outbreaks in the United States in 2011 [3].…”

Section: Introductionmentioning

confidence: 99%

A travel clinic’s role in reducing measles and pertussis in the community

Rapose¹

2016

Clin Res Trials

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Background: There were an increased number of cases of measles in the United States in the year 2011, and in 2012 the US recorded the most number of pertussis cases in a single year compared to the previous fifty years. A Travel Clinic can serve as an important contact point to increase uptake of vaccines against these two diseases. Methods:There was an increased emphasis on testing for measles immunity and vaccination with MMR and Tdap vaccines in persons seeking pre-travel counseling at our Travel Clinic in the year 2011. A retrospective chart analysis of patients seen at the Travel Clinic was performed in 2012. We evaluated the number of MMR and Tdap vaccines administered, as well as the number of persons tested for measles immunity by serology.Results: 1261 persons were evaluated for in-person consultation in 2011. In addition to traditional "travel vaccines", 133 MMR vaccines and 397 Tdap vaccines were administered. In addition, 416 patients were evaluated for measles immunity by serology testing. Conclusions:The Travel Clinic is accessed by a large number of persons prior to their travel abroad. Those who are not up-to-date with Tdap vaccine and those not immune to measles have an opportunity to receive the recommended vaccines at their pre-travel visit. The Travel Clinic hence represents a unique opportunity to increase the uptake of MMR and Tdap vaccines in healthy individuals who may not otherwise visit their primary-care-providers, thus reducing the overall risk of outbreaks in the community.

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Measles Virus Infection and Subacute Sclerosing Panencephalitis

Anlar

Yalaz

2012

Viral Infections of the Human Nervous System

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Measles Elimination in the Americas: A Comparison Between Countries With a One-Dose and Two-Dose Routine Vaccination Schedule

Cited by 7 publications

References 25 publications

Prevention of treatable infectious diseases: A game-theoretic approach

Prevention of treatable infectious diseases: A game-theoretic approach

A travel clinic’s role in reducing measles and pertussis in the community

Measles Virus Infection and Subacute Sclerosing Panencephalitis

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