Mean Platelet Volume, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Severe Preeclampsia

Yavuzcan, Ali; Çağlar, Mete; Üstün, Yusuf; Dilbaz, Serdar; Özdemir, İsmail; Yildiz, Elif; Özbilgeç, Sıtkı; Kumru, Selahattin

doi:10.17772/gp/1713

Cited by 81 publications

(74 citation statements)

References 17 publications

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“…It is worth to mention that Yavuzcan et al21 observed no significant difference in the MPV between women with severe preeclampsia, healthy pregnant women, and healthy non-pregnant women. It is noteworthy that some researchers failed to confirm PC and MPV as predictors of preeclampsia,25,26 probably because of the differences in the methods and/or equipment used to obtain hemogram.…”

Section: Discussionmentioning

confidence: 87%

“…Various indices are used to measure platelet functions, for example, the platelet count (PC), mean platelet volume (MPV), the PC to MPV ratio, and platelet distribution width (PDW); PDW measures platelet size distribution 9. The utility of different platelets indices as predictors of preeclampsia has been studied previously;10–21 however, reports in this regard are controversial. The current study was conducted to evaluate platelets indices in women with preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

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Platelet count and platelet indices in women with preeclampsia

Al-Sheeha¹,

Alaboudi²,

Al-Ghasham³

et al. 2016

VHRM

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BackgroundAlthough the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia.ObjectiveTo compare platelet indices, namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and PC to MPV ratio in women with preeclampsia compared with healthy controls.SettingQassim Hospital, Kingdom of Saudi Arabia.DesignA case–control study. Sixty preeclamptic women were the cases and an equal number of healthy pregnant women were the controls.ResultsThere was no significant difference in age, parity, and body mass index between the study groups. Sixteen and 44 of the cases were severe and mild preeclampsia, respectively. There was no significant difference in PDW and MPV between the preeclamptic and control women. Both PC and PC to MPV ratios were significantly lower in the women with preeclampsia compared with the controls. There was no significant difference in the PC, PDW, MPV, and PC to MPV ratio when women with mild and severe preeclampsia were compared. Using receiver operating characteristic (ROC) curves, the PC cutoff was 248.0×103/µL for diagnosis of pre-eclampsia (P=0.019; the area under the ROC curve was 62.4%). Binary regression suggests that women with PC <248.010×103/µL were at higher risk of preeclampsia (odds ratio =2.2, 95% confidence interval =1.08–4.6, P=0.03). The PC/MPV cutoff was 31.2 for diagnosis of preeclampsia (P=0.035, the area under the ROC curve was 62.2%).ConclusionPC <248.010×103/µL and PC to MPV ratio 31.2 are valid predictors of preeclampsia.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Platelet count and platelet indices in women with preeclampsia

Al-Sheeha¹,

Alaboudi²,

Al-Ghasham³

et al. 2016

VHRM

View full text Add to dashboard Cite

show abstract

“…Similarly, PCT is a well‐known parameter obtained from complete blood count (CBC) . These markers are related to the inflammatory processes of pregnancy, such as gestational diabetes mellitus, acute appendicitis, pre‐eclampsia and preterm labor …”

Section: Introductionmentioning

confidence: 99%

Association between platelet to lymphocyte ratio, plateletcrit and the presence and severity of hyperemesis gravidarum

Çift

Burcu

Özgen

et al. 2017

J of Obstet and Gynaecol

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“…Se ha demostrado que el volumen plaquetario medio durante el primer y tercer trimestre de embarazo es más elevado en embarazadas que posteriormente desarrollan preeclampsia, pero con bajo valor predictivo para el diagnóstico de preeclampsia 22,23 . Otro estudio encontró que el volumen plaquetario medio podría servir como un marcador de monitoreo de inicio y severidad de la preeclampsia 24 .…”

Section: Discussionunclassified

Utilidad diagnóstica del volumen plaquetario medio en embarazadas con preeclampsia

Rondón-Tapía

Mejia-Montilla

Reyna-Villasmil

et al. 2018

Rev. chil. obstet. ginecol.

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Utilidad diagnóstica del volumen plaquetario medio en embarazadas con preeclampsia. RESUMENOBJETIVO: Establecer la utilidad diagnóstica del volumen plaquetario medio en embarazadas con preeclampsia. MÉTODOS: Se realizó un estudio de de casos y controles en el Hospital Central "Dr. Urquinaona", Maracaibo, Venezuela. Se seleccionó un total de 180 embarazadas. Se incluyeron 90 preeclámpticas como grupo de estudio (grupo A) y un grupo de control seleccionado por tener edad e índice de masa corporal similares al grupo de estudio, que consistió en 90 embarazadas normotensas sanas (grupo B). Las muestras de sangre se recolectaron en todas las pacientes antes del parto e inmediatamente después del diagnóstico en el grupo A, para determinar los valores de volumen plaquetario medio. Se determinaron las características generales, valores de volumen plaquetario medio y eficacia diagnóstica. RESULTADOS: Se encontraron diferencias estadísticamente significativas en los valores de volumen plaquetario medio entre las pacientes del grupo A (10,35 +/-1,11 fL) y las pacientes del grupo B (9,54 +/-0,96 fL; p < 0,001). No se observaron correlaciones significativas con los valores de presión arterial sistólica y diastólica (p = ns). Un valor de corte de 10,3 fL presentó un valor por debajo de la curva de 0,71, sensibilidad del 53,3%, especificidad del 63,1%, valor predictivo positivo del 63,2% y valor predictivo negativo del 59,6%, con una exactitud diagnóstica del 61,1%. CONCLUSIÓN: Los valores volumen plaquetario medio no son útiles para discriminar el diagnóstico de preeclampsia en las embarazadas, a pesar que las preeclámpticas presentaron valores significativamente más elevados de al compararlo con embarazadas normotensas sanas.

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Mean Platelet Volume, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Severe Preeclampsia

Cited by 81 publications

References 17 publications

Platelet count and platelet indices in women with preeclampsia

Platelet count and platelet indices in women with preeclampsia

Association between platelet to lymphocyte ratio, plateletcrit and the presence and severity of hyperemesis gravidarum

Utilidad diagnóstica del volumen plaquetario medio en embarazadas con preeclampsia

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