Platelet count and platelet indices in women with preeclampsia

Abstract

BackgroundAlthough the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia.ObjectiveTo compare platelet indices, namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and PC to MPV ratio in women with preeclampsia compared with healthy controls.SettingQassim Hospital, Kingdom of Saudi Arabia.DesignA case–control study. Sixty preeclamptic women were the cases and an equal number of healthy pregnant women were the controls.ResultsThere was no significant difference in age, parity, and body mass index between the study groups. Sixteen and 44 of the cases were severe and mild preeclampsia, respectively. There was no significant difference in PDW and MPV between the preeclamptic and control women. Both PC and PC to MPV ratios were significantly lower in the women with preeclampsia compared with the controls. There was no significant difference in the PC, PDW, MPV, and PC to MPV ratio when women with mild and severe preeclampsia were compared. Using receiver operating characteristic (ROC) curves, the PC cutoff was 248.0×103/µL for diagnosis of pre-eclampsia (P=0.019; the area under the ROC curve was 62.4%). Binary regression suggests that women with PC <248.010×103/µL were at higher risk of preeclampsia (odds ratio =2.2, 95% confidence interval =1.08–4.6, P=0.03). The PC/MPV cutoff was 31.2 for diagnosis of preeclampsia (P=0.035, the area under the ROC curve was 62.2%).ConclusionPC <248.010×103/µL and PC to MPV ratio 31.2 are valid predictors of preeclampsia.

Alterations of Several Serum Parameters Are Associated with Preeclampsia and May Be Potential Markers for the Assessment of PE Severity

“…There have been controversies regarding the value of several hematological parameters (such as D-dimer, Fbg, PLT, MPV, and PDW) and biochemical tests (such as ALB, TP, PA, ALP, and LDH) in PE prediction or in the evaluation of PE severity. For example, the value of platelet count and platelet indices in PE is supported by several studies; however, there are also studies that found no significance [23][24][25]. The significance of ALB in assessing the onset and severity of preeclampsia is also controversial [26,27].…”

Study of a Two-Step Centrifugation Protocol for Concentrating Cells and Growth Factors in Bovine Platelet-Rich Plasma

“…MPV and PDW are frequently used parameters for indicating PLT activation in humans [34, 35], horses [17, 36], dogs [37, 38], and cattle [39], among others. These parameters are useful to determine PRP quality.…”

Study of the effect of selective inhibitor of Arginase II KUD 975 and of low doses of Acetylsalicylic acid on the functional parameters of the cardiovascular system In experimental preeclampsia

“…The positive effects of aspirin are related to its ability to irreversibly inhibit cyclooxygenase 1 (COX 1) of platelets (AlSheeha et al 2016, Khodzhaeva et al 2018). This reduces the formation of thromboxane A2, which causes vasoconstriction and activation of platelet adhesion and aggregation.…”

“…In recent years, the number of studies indicating that the main role in the development of preeclampsia is played by a violation of the functional state of the vascular endothelium, which entails the development of a generalized spasm, increased blood pressure and, as a consequence, ischemic disorders in the organs. In addition, especially dangerous and attracting an increased attention are disturbances in the hemostatic system in preeclampsia (AlSheeha et al 2016, Severinova et al 2019.…”