Mean Platelet Volume (MPV) as an indicator of  disease activity and severity in lupus

Khan, Abidullah; Haider, Iqbal; Ayub, Maimoona; Khan, Salman

doi:10.12688/f1000research.10763.2

Cited by 15 publications

(22 citation statements)

References 26 publications

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“…On the other hand, Khan et al. 11 found that MPV was significantly lower in adult patients with active lupus than those without a flare and this may be attributed to the consumption of the large and activated platelets at the site of inflammation, leaving small platelets behind. Also, Hartmann et al.…”

Section: Discussionmentioning

confidence: 98%

Mean platelet volume in children with systemic lupus erythematosus

Talat

Allah

Khalifa

et al. 2020

Lupus

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Background Platelets are heterogeneous in size, density, metabolic, functional, and biochemical properties. Mean platelet volume (MPV) is a measure of the average size of platelet in a blood sample. Aim We aimed to evaluate the mean platelet volume as a marker for disease activity in children with systemic lupus erythematosus. Materials and Methods This was a prospective case-control study, which included 50 patients with SLE and 50 age and sex, matched healthy controls. All subjects were subjected to history taking, physical examination and laboratory parameters in active and remission phases of the diseases. Results The MPV value in the SLE group was significantly higher than control group (9.6 ± 1.3 fL, 9.1 ± 0.57 fL, respectively, p = 0.04). There was a significant increase of weight, blood pressure, urea, creatinine, proteinuria, CRP, ESR, cholestrol, MPV values, SLEDAI-2K scores and significant decrease of HB, albumin, C3, mean platelet volume (MPC) in the active stage than in the remission stage. There was a significant negative correlation between MPV and MPC in active stage of the disease but the correlation was insignificant in remission stage. Conclusion MPV increased in active phase of patients with SLE and can be an easy, rapid, inexpensive and simple method to assess disease activity in children with SLE.

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Section: Discussionmentioning

confidence: 98%

Mean platelet volume in children with systemic lupus erythematosus

Talat

Allah

Khalifa

et al. 2020

Lupus

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“…The mean platelet volume (MPV) is widely used for assessing platelet activation in various inflammatory conditions. However, the current literature on MPV in SLE is contradictory and the usefulness of MPV as a biomarker in SLE still need to be explored (20, 98–101). On the molecular level, the production of thromboxane, P-selection expression and the release of sCD40L, PMPs and β-thromboglobulin have been reported as markers for platelet activation.…”

Section: Platelets Role In Skin Autoimmune Diseasesmentioning

confidence: 99%

Platelets in Skin Autoimmune Diseases

2019

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Systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and small vessel vasculitis are three autoimmune diseases frequently manifested in the skin. They share common pathogenic features, including production of autoantibodies, loss of tolerance to self-antigens, tissue necrosis and fibrosis, vasculopathy and activation of the coagulation system. Platelets occupy a central part within the coagulation cascade and are well-recognized for their hemostatic role. However, recent cumulative evidence implicates their additional and multifaceted immunoregulatory functions. Platelets express immune receptors and they store growth factors, cytokines, and chemokines in their granules enabling a significant contribution to inflammation. A plethora of activating triggers such as damage associated molecular patterns (DAMPs) released from damaged endothelial cells, immune complexes, or complement effector molecules can mediate platelet activation. Activated platelets further foster an inflammatory environment and the crosstalk with the endothelium and leukocytes by the release of immunoactive molecules and microparticles. Further insight into the pathogenic implications of platelet activation will pave the way for new therapeutic strategies targeting autoimmune diseases. In this review, we discuss the inflammatory functions of platelets and their mechanistic contribution to the pathophysiology of SSc, ANCA associated small vessel vasculitis and other autoimmune diseases affecting the skin.

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“…One of these was excluded because they included other diseases [31]. Thus, nine articles met the inclusion criteria [3,[10][11][12][13][14][15][16][17] (Table 1, Figure 1). One report contained data on two different groups [12], so we analyzed these studies independently.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Studies on NLR, PLR, and MPV in SLE patients compared to healthy controls, on the relationship between NLR, PLR, and MPV levels and SLE activity, and on the association of NLR with renal involvement in SLE have reported controversial results [3,[10][11][12][13][14][15][16][17]. This may be because of the small sample sizes, low statistical power, and/or the presence of clinical heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume with Systemic Lupus Erythematosus Disease Activity: A Meta-analysis

Lee

Song

2017

J Rheum Dis

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Objective. A series of common blood tests neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) could provide a measure of systemic lupus erythematosus (SLE) activity. Methods. We searched the Medline, Embase, and Cochrane databases and performed a meta-analysis comparing NLR, PLR, and MPV in patients with SLE to controls, and examined correlation coefficients between NLR, PLR, and MPV and SLE activity based on SLE Disease Activity Index (SLEDAI) using random-effects models. Results. Nine studies were included in this meta-analysis. Meta-analysis revealed that NLR was significantly higher in the SLE group than in the control group (standard mean difference [SMD]=2.747, 95% confidence interval [CI]=1.241∼4.254, p＜0.001). PLR was also significantly higher in the SLE group (SMD=1.564, 95% CI=0.122∼3.006, p=0.034). Meta-analysis of correlation coefficients showed that both NLR and PLR were positively associated with SLEDAI (correlation coefficient=0.404, 95% CI=0.299∼0.500, p＜0.001; correlation coefficient=0.378, 95% CI=0.234∼0.505, p＜0.001). The pooled sensitivity and specificity of NLR for diagnosis of lupus nephritis were 75.1% (95% CI, 68.5∼81.0) and 72.9% (95% CI, 64.9∼80.0), respectively. The area under the curve of NLR were 0.794. However, meta-analysis indicated no elevated MPV in the SLE group and no correlation between MPV and SLE activity. Conclusion. This meta-analysis demonstrated that both NLR and PLR are higher in patients with SLE, a significantly positive correlation exists between NLR/PLR and SLE activity. (J Rheum Dis 2017;24:279-286)

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Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus

Cited by 15 publications

References 26 publications

Mean platelet volume in children with systemic lupus erythematosus

Mean platelet volume in children with systemic lupus erythematosus

Platelets in Skin Autoimmune Diseases

Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume with Systemic Lupus Erythematosus Disease Activity: A Meta-analysis

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