Platelets in Skin Autoimmune Diseases

Liu, Xiaobo; Gorzelanny, Christian; Schneider, Stefan W.

doi:10.3389/fimmu.2019.01453

Cited by 19 publications

(24 citation statements)

References 241 publications

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“…[36] With regard to HA, it is believed to have both tumor-promoting and suppressing properties. [37] Our results provide insights into the dual nature of HA. In contrast to our findings due to the combined effects of CXCL12-γ and HA, the addition of HA alone to collagen-based matrices suppresses angiogenesis and vessel permeability.…”

Section: Discussionmentioning

confidence: 73%

Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties

Chang

Seibel

Avendano

et al. 2020

Adv Healthcare Materials

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Angiogenesis is associated with increased vessel sprouting and permeability. Important mediators of these angiogenic responses include local environment of signaling molecules and supporting extracellular matrix (ECM). However, dissecting the interplay of these instructive signals in vivo with multiple cells and extracellular molecules remains a central challenge. Here, microfluidic biomimicry is integrated with 3D ECM hydrogels that are well‐characterized for molecular‐binding and mechanical properties to reconstitute vessel‐like analogues in vitro. This study focuses on three distinct isoforms of the pro‐metastatic chemokine CXCL12. In collagen‐only hydrogel, CXCL12‐α is the most potent isoform in promoting sprouting and permeability, followed by CXCL12‐β and CXCL12‐γ. Strikingly, addition of hyaluronan (HA), a large and negatively charged glycosaminoglycan, with collagen matrices selectively increases vessel sprouting and permeability conferred by CXCL12‐γ. This outcome is supported by the measured binding affinities to collagen/HA ECM, suggesting that negatively charged HA increases the binding of CXCL12‐γ to augment its angiogenic potency. Moreover, it is shown that addition of HA to collagen matrices on its own decreases vessel sprouting and permeability, and these responses are nullified by blocking the HA receptor CD44. Collectively, these results demonstrate that differences in binding to extracellular HA help underlie CXCL12 isoform‐specific responses toward directing angiogenesis.

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Section: Discussionmentioning

confidence: 73%

Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties

Chang

Seibel

Avendano

et al. 2020

Adv Healthcare Materials

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“…Platelets have also been engaged in inflammation and regulating immune responses in addition to the quintessential roles in hemostasis and thrombosis. Activated platelets could help to foster an inflammatory environment by the release of biologically active molecules in some skin disorders, such as systemic sclerosis and systemic lupus erythematosus [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis

et al. 2020

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Background: Psoriasis is an immune-mediated inflammatory skin disease in conjunction with the systemic inflammatory process. It appears to be related to increased risks of cardiovascular disease events, especially in severe cases. The hemostatic balance is disrupted due to the prothrombotic bias in psoriasis, which might be mainly preserved by platelet hyperactivity. Platelets are also immune cells that initiate and regulate immune and inflammatory processes, except as the principal mediator of hemostasis and thrombosis, and platelet dysfunction is deeply involved in the pathogenesis of psoriasis. Summary: The aim of this study is to perform a review that expounds abnormal platelet function in psoriasis and explains the important role of platelets in the pathogenic mechanism of psoriasis in order to provide new targets for comprehensive medical treatment.

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“…Additionally, activated platelets could stimulate an inflammatory environment by releasing biologically active molecules in some skin disorders, such as psoriasis, systemic lupus erythematous and multiple sclerosis. [ 49 ] Cytokines released by activated platelets are reported to play a key role in psoriasis. Platelets are the major source of IL-1β, and an increased IL-1 level is involved in the development and progression of inflammation in psoriasis.…”

Section: The Pathogenic Connection Between Psoriasis and Vascular Diseasementioning

confidence: 99%

The Association Between Psoriasis and Cardiovascular Diseases

2021

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Cardiovascular diseases and psoriasis have been well established as separate entities, however, there is uncertainty with regards to a link between the two diseases. A few environmental, psychological and social factors have been implicated as potential common risk factors that may exacerbate the two diseases, and an array of complex immune and non-immune inflammatory mediators can potentially explain a plausible link. Pharmacotherapy has also played a role in establishing a potential association, especially with the advent of biological agents which directly act on inflammatory factors shared by the two diseases. This review will look at existing evidence and ascertain a potential correlation between the two.

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Platelets in Skin Autoimmune Diseases

Cited by 19 publications

References 241 publications

Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties

Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties

Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis

The Association Between Psoriasis and Cardiovascular Diseases

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