Mean platelet volume is associated with infarct size and microvascular obstruction estimated by cardiac magnetic resonance in ST segment elevation myocardial infarction

Andrés, Óscar; Cubillos-Arango, A.; Ferrando-Beltrán, Mónica; Bochard-Villanueva, Bruno; García-González, Pilar; Estornell-Erill, Jordi; Berenguer-Jofresa, Alberto; Fácila, Lorenzo; Ridocci-Soriano, Francisco; Morell, Salvador

doi:10.1093/eurheartj/eht310.p4890

Cited by 3 publications

(3 citation statements)

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“…Recently, the relationship between MPV and infarct size (percentage with respect to the total myocardial mass) in STEMI patients was reported (53). There are no reports of a significant association between peak hsCRP level or MPV and infarct transmurality in STEMI patients who underwent primary PCI.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Infarct Transmurality From C‐Reactive Protein Level and Mean Platelet Volume in Patients With ST‐Elevation Myocardial Infarction: Comparison of the Predictive Values of Cardiac Enzymes

Kim

Choi

Kim

et al. 2016

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 99%

Prediction of Infarct Transmurality From C‐Reactive Protein Level and Mean Platelet Volume in Patients With ST‐Elevation Myocardial Infarction: Comparison of the Predictive Values of Cardiac Enzymes

Kim

Choi

Kim

et al. 2016

Clinical Laboratory Analysis

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“…Platelets play a critical role in the pathogenesis and prognosis of ACS [5]. They secrete a number of substances that are key mediators of coagulation, thrombosis and atherosclerosis [6].…”

Section: Introductionmentioning

confidence: 99%

Predictors of thrombus burden and no-reflow of infarct-related artery in patients with ST-segment elevation myocardial infarction

Cakici

Çetın²,

Ballı³

et al. 2014

Blood Coagulation &Amp; Fibrinolysis

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Preprocedural high-thrombus burden (HTB) of infarct-related artery (IRA) is a harbinger of procedural complications following primary percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI). The HTB of IRA can lead to poor outcomes by various mechanisms, including no-reflow phenomenon, increased myocardial necrosis and with subsequent reduced survival benefit at follow-up. In this study, we investigated the relationship between all platelet indices on admission and thrombus burden and the no-reflow phenomenon after primary PCI of IRA in patients with STEMI. We retrospectively enrolled 475 patients with STEMI undergoing primary PCI. Study population was divided into two groups according to the thrombolysis in myocardial infarction thrombus grade of IRA as low-thrombus burden or HTB. There were no statistically significant differences in platelet indices, including platelet count, platelet-large cell ratio (P-LCR), mean platelet volume (MPV) and platelet distribution with (PDW) among the groups. However, in the subgroup analysis, P-LCR, MPV and PDW were significantly higher in the no-reflow patients than reflow patients despite similar platelet count (P for all < 0.001). The cutoff value of P-LCR for predicting no-reflow was 26.5% with a sensitivity of 67.0% and a specificity of 62% (area under the curve, 0.689; 95% confidence interval, 0.614-0.765; P < 0.001). Furthermore, P-LCR, MPV and PDW had similar AUC (0.689, P < 0.001; 0.688, P < 0.001; and 0.677, P < 0.001; respectively) for predicting no-reflow phenomenon after primary PCI. As a result, all of the platelet indices have no effect on thrombus load of IRA, however, these parameters seem to impair epicardial perfusion after primary PCI.

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“…Circulating platelets are heterogeneous in size, density and reactivity [1,2], and changes in these variables are important for the development of acute coronary syndromes [3]. There is strong evidence indicating that the corpuscular volume of the platelets, also know as mean platelet volume (MPV), is an important variable in predicting systemic inflammation and the thrombotic potential of the blood [4].…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume is a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction

Ghaffari

Pourafkari

Javadzadegan

et al. 2015

Thrombosis Research

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Mean platelet volume is associated with infarct size and microvascular obstruction estimated by cardiac magnetic resonance in ST segment elevation myocardial infarction

Cited by 3 publications

References 0 publications

Prediction of Infarct Transmurality From C‐Reactive Protein Level and Mean Platelet Volume in Patients With ST‐Elevation Myocardial Infarction: Comparison of the Predictive Values of Cardiac Enzymes

Prediction of Infarct Transmurality From C‐Reactive Protein Level and Mean Platelet Volume in Patients With ST‐Elevation Myocardial Infarction: Comparison of the Predictive Values of Cardiac Enzymes

Predictors of thrombus burden and no-reflow of infarct-related artery in patients with ST-segment elevation myocardial infarction

Mean platelet volume is a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction

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