Mean platelet volume is a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction

Ghaffari, Samad; Pourafkari, Leili; Javadzadegan, Hassan; Masoumi, Nayyer; Jafarabadi, Mohammad Asghari; Nader, Nader D.

doi:10.1016/j.thromres.2015.05.003

Cited by 20 publications

(20 citation statements)

References 34 publications

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“…12 Platelets are involved in the pathogenesis of various diseases and elevated MPV has been associated with higher risk of adverse events in several disease conditions, such as acute coronary syndrome, stroke. 13,14 Higher MPV is also reported in the venous thromboembolism setting. 15,16 It has been reported to be a risk indicator for predicting the possibility of PTE in patients with unprovoked DVT.…”

Section: Discussionmentioning

confidence: 94%

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Ghaffari

Parvizian

Pourafkari

et al. 2020

J Cardiovasc Thorac Res

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Introduction: Given the role of platelets in thrombus formation, markers of platelet activation may be able to predict outcomes in patients with acute pulmonary thromboembolism (PTE). Methods: In a prospective cohort study, 492 patients with acute PTE were enrolled. Patients were evaluated for platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and platelet-lymphocyte-ratio (PLR), as well as for the simplified Pulmonary Embolism Severity Index (PESI) risk score. The primary endpoint was in-hospital all-cause mortality. Major adverse cardiopulmonary events (MACPE, composite of mortality, thrombolysis, mechanical ventilation and surgical embolectomy during index hospitalization) and all-cause death during follow-up were secondary endpoints. Results: MPV, PDW and PLR were 9.9±1.0 fl, 13.5±6.1%, and 14.7±14.5, respectively, in the total cohort. Whilst MPV was higher in those with adverse events (10.1±1.0 vs 9.9±1.0 fl; P = 0.019), PDW and PLR were not different between two groups. MPV with a cut-off point of 9.85 fl had a sensitivity of 81% and a specificity of 50% in predicting in-hospital mortality, but it had lower performance in predicting MACPE (Area under the curve: AUC 0.58; 95%CI 0.52-0.63) or long-term mortality (AUC 0.54; 95% CI 0.47-0.61). The AUC for all these three markers were lower than the AUC calculated for the simplified PESI score (0.80; 0.71-0.88). Conclusion: Platelet indices had only fair-to-good predictive performance in predicting in-hospital all-cause death. Established PTE risk scoring models such as simplified PESI outperform these indices in predicting adverse outcomes. Article info TUOMS P R E S SPlatelets indicies in acute pulmonary thromboembolism

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Section: Discussionmentioning

confidence: 94%

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Ghaffari

Parvizian

Pourafkari

et al. 2020

J Cardiovasc Thorac Res

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“…High MPV is an independent predictor of large intracoronary thrombus burden and short-term mortality in STEMI patients (Lai et al, 2015). Also, it is associated with lower ST-segment resolution and higher prevalence of major adverse cardiac events in patients receiving thrombolytic therapy for first time STEMI (Ghaffari et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction

Hudzik

Szkodziński

Lekston

et al. 2016

Journal of Diabetes and its Complications

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“…Apart from their effects on thrombosis, platelets are also inflammatory cells. They release several substances, including thromboxane A2, platelet factor 4, P-selectin, platelet derived growth factor, and chemotactic and mitogenic factor contributing to vascular neointimal proliferation [ 34 – 36 ]. Large platelets are metabolically and enzymatically more active than small ones [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease

Sıncer¹,

Güneş²,

Mansıroğlu³

et al. 2018

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IntroductionThe prognostic value of hematological indices in cardiovascular diseases and the association between these parameters and cardiovascular conditions have been established in the literature.AimIn this study, we aimed to investigate the relation of mean platelet volume (MPV), MPV to platelet ratio (MPR) and red cell distribution width (RDW) with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical coronary artery stenosis.Material and methodsA total of 306 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: a group with adequate CCD (n = 214) and a group with impaired CCD (n = 92). Routine complete blood count and biochemical parameters were measured before coronary arteriography.ResultsThe MPV and MPR levels were significantly higher in the inadequate CCD group (10.5 ±1.8 fl vs. 8.7 ±1.9 fl, p < 0.001 and 0.06 ±0.08 vs. 0.05 ±0.07, p = 0.036). Patients with inadequate CCD had significantly higher RDW levels compared to patients with adequate CCD (15.5 ±1.7% vs. 15.0 ±1.9%, p = 0.01). MPV and RDW were significantly associated with Rentrop collateral grading (r = –0.523, p < 0.001 and r = –0.239, p < 0.001, respectively), whereas the association with MPR was not significant. An MPV value greater than 9.95 fl, determined with ROC curve analysis, had 71% sensitivity and 70% specificity in predicting inadequate CCD. An RDW greater than 14.3% has 71% sensitivity and 53% specificity in selecting patients with adequate CCD.ConclusionsThe present study suggests that MPV and MPR may be associated with the degree of collateral development in chronic stable CAD. However, the negative association of RDW with inadequate CCD, in combination with previous contradictory reports, raises a doubt about the possible value of RDW in stable CAD. Although these parameters may be affected by various conditions, a high MPV may lead clinicians to suspect possible inadequate collateral development in stable CAD patients.

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Mean platelet volume is a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction

Cited by 20 publications

References 34 publications

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction

Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease

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