Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease

Abstract

IntroductionThe prognostic value of hematological indices in cardiovascular diseases and the association between these parameters and cardiovascular conditions have been established in the literature.AimIn this study, we aimed to investigate the relation of mean platelet volume (MPV), MPV to platelet ratio (MPR) and red cell distribution width (RDW) with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical coronary artery stenosis.Material and methodsA total of 306 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: a group with adequate CCD (n = 214) and a group with impaired CCD (n = 92). Routine complete blood count and biochemical parameters were measured before coronary arteriography.ResultsThe MPV and MPR levels were significantly higher in the inadequate CCD group (10.5 ±1.8 fl vs. 8.7 ±1.9 fl, p < 0.001 and 0.06 ±0.08 vs. 0.05 ±0.07, p = 0.036). Patients with inadequate CCD had significantly higher RDW levels compared to patients with adequate CCD (15.5 ±1.7% vs. 15.0 ±1.9%, p = 0.01). MPV and RDW were significantly associated with Rentrop collateral grading (r = –0.523, p < 0.001 and r = –0.239, p < 0.001, respectively), whereas the association with MPR was not significant. An MPV value greater than 9.95 fl, determined with ROC curve analysis, had 71% sensitivity and 70% specificity in predicting inadequate CCD. An RDW greater than 14.3% has 71% sensitivity and 53% specificity in selecting patients with adequate CCD.ConclusionsThe present study suggests that MPV and MPR may be associated with the degree of collateral development in chronic stable CAD. However, the negative association of RDW with inadequate CCD, in combination with previous contradictory reports, raises a doubt about the possible value of RDW in stable CAD. Although these parameters may be affected by various conditions, a high MPV may lead clinicians to suspect possible inadequate collateral development in stable CAD patients.

Stabi̇l Koroner Arter Hastaliği Olan Yaşli Erkeklerde Ruti̇n İnflamatuar Markerler Ve Ejeksi̇yon Fraksi̇yonu Arasindaki̇ İli̇şki̇

“…Another examined hematological maker is mean RDW. In one study, it was shown that high RDW and MPV values in patients with SCAD showed a negative correlation with collateral development (22). In our study, we found that RDW and MPV values were significantly higher in the group 1 than in the group 2.…”

Initial red cell distribution width as a predictor of poor neurological outcomes in out-of-hospital cardiac arrest survivors in a prospective, multicenter observational study (the KoCARC study)

“…However, elevated RDW may be related myocardial ischemia, as heart failure caused by atherosclerosis of the coronary vessel walls is stimulated by inflammation 9,23,24 . Some studies have shown that RDW is an effective prognostic factor for outcomes in critically ill patients and septic patients [28][29][30][31][32] .…”

“…High red cell distribution width (RDW) values are used as a predictor of poor prognosis in many diseases, including cardiovascular diseases, perioperative stroke, malignancies and respiratory diseases 4 – 8 . Elevated RDW values are associated with adequate collateral development in patients with stable coronary artery disease and perioperative stroke in patients undergoing cardiac valve surgery 9 , 10 . Additionally, high RDW is associated with inflammatory conditions in various diseases, such as Hashimoto’s thyroiditis, rheumatoid arthritis, inflammatory bowel disease and gastrointestinal disorders 11 – 14 .…”

Does Mean Platelet Volume to Lymphocyte Ratio Associates with Irritable Bowel Syndrome and its subtypes?

“…In a recent study it has been reported that, MPV of subjects with vitamin D deficiency, another condition that associated with low grade inflammation, have greater MPV values compared to subjects with normal serum vitamin D levels (14). Increased MPV has been also shown in stable coronary artery disease patients who have inadequate coronary collateral development (15). Moreover, MPV has been studied in IBS in literature and authors reported elevated MPV in patients with IBS compared to healthy subjects (16).…”