Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study

Abstract

Summary. Background: Platelet size, measured as mean platelet volume (MPV), is associated with platelet reactivity. MPV is increased in acute myocardial infarction, and has been identified as an independent risk factor for future myocardial infarction and stroke. Objectives: The purpose of the study was to determine the impact of platelet count and MPV on the incidence of venous thromboembolism (VTE) in a prospective, population-based study. Methods: Platelet count, MPV and baseline characteristics were registered in 25 923 subjects aged 25-96 years who participated in the Tromsø Study in 1994-1995. Incident VTE events were registered to the end of followup (1 September 2007). Results: There were 445 validated incident VTE events (1.6 per 1000 person-years), of which 186 (42%) were unprovoked, during a mean of 10.8 years of followup. Subjects with MPV ‡ 9.5 fL had a 1.3-fold [95% confidence interval (CI) 1.0-1.7] higher risk of total VTE and a 1.5-fold (95% CI 1.1-2.3) higher risk of unprovoked VTE than subjects with MPV < 8.5 fL in analyses adjusted for age, sex, smoking, body mass index, and platelet count. Increasing MPV was associated with increased risk of total VTE (P for trend = 0.09) and unprovoked VTE (P for trend = 0.03) in analyses adjusted for age and sex. There was no significant association between increasing platelet count and risk of VTE. Conclusions: An increasing MPV was identified as a predictor for VTE, in particular VTE of unprovoked origin. The present findings support the concept that platelet reactivity is important in the pathogenesis of VTE.

Acute infection as a trigger for incident venous thromboembolism: Results from a population‐based case‐crossover study

“…Incident VTE events among the study participants were recorded from the date of enrollment (1994‐95) until December 31, 2012. For each potential VTE case the medical records were reviewed by trained personnel, and VTE events were adjudicated and recorded when clinical signs and symptoms of DVT or PE were combined with objective confirmation by radiological procedures, and resulted in a VTE diagnosis requiring treatment, as described in detail previously 19. The University Hospital of North Norway is the only hospital serving the Tromsø region, and all relevant diagnostics and hospital care are provided by this hospital.…”

Evaluation of Procalcitonin and hs-CRP Levels in Sudden Sensorineural Hearing Loss

“…An increase in the mean platelet volume (MPV) is seen in vascular events such as atheroscherosis, acute syndromes, venous and arterial thrombosis, or thromboembolism [20][21][22] . Previous reports have investigated the relationship between MPV levels and ISSNHL.…”

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

“…Patients with conditions that have been considered to influence platelet indices were excluded from the study. Exclusion criteria were: (1) previous thromboembolism, (2) known malignancy, (3) immobilization, (4) inability to attend follow-up visits, (5) pregnancy, (6) ventricular systolic dysfunction, (7) trauma, (8) a new previous surgical operation, (9) atrial fibrillation, (10) obesity, (11) arterial stroke, (12) peripheral vascular disease, (13) infection, (14) acute coronary syndromes, (15) chronic renal or hepatic diseases, (16) diabetes mellitus, (17) acute and chronic PE and (18) recurrent episode of DVT. Control group consisted of patients with uncomplicated primary varicose veins of the lower limbs.…”

“…Previous studies have shown platelet reactivity in patients with PE and DVT [7][8][9][10][11][12]. Mean platelet volume (MPV) is a measure of average platelet size [13,14].…”