Evaluation of Procalcitonin and hs-CRP Levels in Sudden Sensorineural Hearing Loss

Göde, Sercan; Turhal, Göksel; Kaya, İsa; Mavili, Halil İbrahim; Kirazlı, Tayfun

doi:10.5152/iao.2017.2780

Cited by 10 publications

(24 citation statements)

References 25 publications

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“…[21] Gul et al [22] investigated oxidative imbalance in sudden hearing loss and found that total oxidant status levels were higher in patients suffering from ISSNHL than the healthy control group. Higher procalcitonin levels were detected in ISSNHL patients, compared to healthy individuals, as reported by Göde et al [23] Kim et al [24] also reported that vertebrobasilar loop was associated with a sudden sensorineural hearing loss in their study which provided more proof toward importance of ischemia as a potential cause for ISSNHL.…”

Section: Discussionsupporting

confidence: 58%

Ischemia-modified albumin levels in patients with idiopathic sudden sensorineural hearing loss

Cırık¹

2019

Tr-ENT

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Objectives: This study aims to investigate whether serum levels of ischemia-modified albumin (IMA) are associated with idiopathic sudden sensorineural hearing loss (ISSNHL). Patients and Methods: Between December 2015 and June 2017, a total of 17 patients (9 males, 8 females; mean age 49.4±18.0 years; range, 24 to 88 years) with ISSNHL and 24 age-and sex-matched healthy individuals (12 males, 12 females; mean age 44.5±13.3 years; range, 30 to 81 years) as the control group were included in the study. All patients underwent audiometric examination at the time of admission immediately before the beginning of the treatment and weekly after treatment initiation until one month using the Interacoustics AC40 audiometer. Serum IMA levels were evaluated using blood samples from the antecubital vein of both patient and control groups. The samples were centrifuged to separate the serum from the cells. Albumin cobalt binding test was used for IMA measurement. Results: The mean IMA level was 0.374±0.081 absorbance units (ABSU) (range, 0.205 to 0.536) in the study group at the time of diagnosis, 0.358±0.051 ABSU (range, 0.297 to 0.466) in the post-treatment period, at least four weeks after onset, and 0.358±0.053 ABSU (range, 0.281 to 0.434) in the control group. There was no statistically significant difference between the patient and control groups. The IMA levels of the patients with ISSNHL in the post-treatment period were lower than the onset of illness, although this difference was not statically significant (0.440). Conclusion: Our study results demonstrated that serum IMA levels in the patients with ISSNHL did not differ from the control group.

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Section: Discussionsupporting

confidence: 58%

Ischemia-modified albumin levels in patients with idiopathic sudden sensorineural hearing loss

Cırık¹

2019

Tr-ENT

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“…CRP concentration may be indicative of infection and the efficacy of treatment [ 39 ]. A study that analyzed hs-CRP and procalcitonin found that only procalcitonin concentration was significantly higher in patients with SSNHL than in control subjects, suggesting that procalcitonin may be indicative of inflammatory etiology in patients with SSNHL [ 40 ]…”

Section: Biomarkers In Ssnhlmentioning

confidence: 99%

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

Doo

Kim

et al. 2020

IJMS

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Sudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors have been found to affect treatment outcomes. Various studies are being performed to determine the prognosis and effects of treatment in patients who experience sudden hearing loss, and to identify biomarkers associated with this condition. Embase, PubMed, and the Cochrane database were searched using the key words SSNHL, prognostic, and biomarker. This search identified 4 articles in Embase, 28 articles in PubMed, and 36 in the Cochrane database. Of these 68 articles, 3 were duplicates and 37 were unrelated to the research topic. After excluding these articles, the remaining 28 articles were reviewed. Factors associated with SSNHL were divided into six categories: metabolic, hemostatic, inflammatory, immunologic, oxidative, and other factors. The associations between these factors with the occurrence of SSNHL and with patient prognosis were analyzed. Low monocyte counts, low neutrophil/lymphocyte ratio (NLR) and monocyte/high-density lipoproteins (HDL) cholesterol ratio (MHR), and low concentrations of fibrinogen, platelet glycoprotein (GP) IIIa, and TNF-α were found to be associated with good prognosis. However, these factors alone could not completely determine the onset of and recovery from SSNHL, suggesting the need for future basic and clinical studies.

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“…Some authors found no relationship between the CRP level and SSNHL. 7,13,14 One study suggested that the CRP/Alb ratio might be prognostic of SSNHL development. 10 We sought relationships between inflammatory parameters (the CRP level, CRP/Alb ratio, and NLR) and SSNHL.…”

Section: Introductionmentioning

confidence: 99%

The Roles Played by Blood Inflammatory Parameters in Sudden Sensorineural Hearing Loss

Guo

Liu

2021

Ear Nose Throat J

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Objective: The etiology of sudden sensorineural hearing loss (SSNHL) remains unknown; inflammation may be one cause. We retrospectively studied SSHNL cases in terms of the inflammatory parameters involved. Methods: We reviewed 169 SSNHL cases. The control group contained 132 patients with vocal cord polyps. The C-reactive protein (CRP) level, CRP/serum albumin (Alb) ratio, and neutrophil/lymphocyte ratio (NLR) were compared between the 2 groups. The relationships between these parameters and the time to treatment after SSHNL onset, hearing level, and therapeutic effects were also analyzed. Results: The CRP level, CRP/Alb ratio, and NLR were higher in SSNHL patients than in controls, but only the NLR differed significantly between the 2 groups. We found no significant differences between patients with different hearing levels, those evaluated at various times after SSNHL onset, and those with different outcomes. Conclusion: The NLR is a reliable SSNHL diagnostic marker. The CRP level and CRP/Alb ratio are not useful indicators.

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Evaluation of Procalcitonin and hs-CRP Levels in Sudden Sensorineural Hearing Loss

Cited by 10 publications

References 25 publications

Ischemia-modified albumin levels in patients with idiopathic sudden sensorineural hearing loss

Ischemia-modified albumin levels in patients with idiopathic sudden sensorineural hearing loss

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

The Roles Played by Blood Inflammatory Parameters in Sudden Sensorineural Hearing Loss

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