Mean platelet volume increase after tamoxifen, but not after anastrazole in adjuvant therapy of breast cancer

Karagöz, Bülent; Bilgi, Oğuz; Alacacıoğlu, Ahmet; Ozgun, Alpaslan; Sayan, Özkan; Erikçi, Alev Akyol; Kandemir, Emin Gökhan

doi:10.1007/s12032-009-9191-2

Cited by 11 publications

(10 citation statements)

References 16 publications

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“…Large platelets are more reactive than their smaller counterparts, and are more likely to aggregate, leading to thrombosis. Large platelets are an independent risk factor for myocardial infarction, as platelet size is a predictor of recurrent myocardial infarction and death ( 14 ). The MPV tested in our study can be easily evaluated by hematological analyzers, which makes it a convenient marker of platelet functions and activation ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer

Xiang‐dong¹,

Xia

Lian³

et al. 2016

Oncology Letters

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Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related mortalities worldwide. Platelets play an important and multifaceted role in cancer progression. Elevated mean platelet volume (MPV) detected in peripheral blood has been identified in various types of cancer. In the present study, we investigated the application value of MPV in early diagnostic and prognostic prediction in patients with resectable gastric cancer. In total, 168 patients with resectable gastric cancer were included and separated into the gastric cancer and healthy control groups according to median pre-operatic MPV value (MPV low, <10.51 or MPV high, ≥10.51). The results showed that the pre-operatic MPV level was significantly higher in gastric cancer patients compared with the healthy subjects. Low pre-operatic MPV level correlated with improved clinicopathological features, including decreased depth of invasion, less lymphonodus metastasis and early tumor stage. The Kaplan-Meier plots showed that the patients with higher pre-operatic MPV had decreased overall survival (OS) and disease-free survival (DFS). Surgical tumor resection resulted in a significant decrease in the MPV level. The patients whose MPV level decreased following surgery had an improved OS. Multivariate Cox regression analysis revealed that the depth of invasion, lymphonodus metastasis, American Joint Committee on Cancer (AJCC) stage, and changes in MPV following surgery were prognostic factors affecting OS, and the AJCC stage and pre-operatic MPV were prognostic factors affecting DFS. In conclusion, MPV measurement can provide important diagnostic and prognostic results in patients with resectable gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer

Xiang‐dong¹,

Xia

Lian³

et al. 2016

Oncology Letters

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show abstract

“…Evidence has shown that the larger PLTs are more reactive than the smaller ones and are more likely to aggregate, leading to thrombosis. Large PLTs (LPLTs) are independent risk factors for myocardial infarction, and PLT size is one predictor of recurrent myocardial infarction and death ( 19 ). A high level of MPV, a marker of PLT size, may indicate tendency towards thrombosis, and has been demonstrated in the case of myocardial infarction and cerebrovascular embolus ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer

et al. 2015

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Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related mortalities worldwide. Platelets play an important and multifaceted role in cancer progression. Elevated mean platelet volume (MPV) detected in peripheral blood has been identified in various types of cancer. In the present study, we investigated the application value of MPV in the prediction of chemotherapy response and prognosis in patients with unresectable gastric cancer. A total of 128 patients with unresectable gastric cancer were included and divided according to the median values of baseline MPV (low MPV: <11.65 or high MPV: ≥11.65). A low baseline MPV level was correlated with reduced metastasis. The results showed that patients with a low baseline level of MPV improved response to chemotherapy. Changes in MPV were associated with therapeutic efficacy. Patients who remained in or were transferred into the low MPV level subgroup following first-line chemotherapy had improved response, compared to those remaining in or being transferred into the high MPV level group. The patients with a higher baseline MPV had decreased progression-free and overall survival ratios. Univariate and multivariate analyses revealed that baseline MPV was a prognostic factor affecting progression-free survival. In conclusion, the results showed that MPV measurements can provide important prognostic information for gastric cancer patients.

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“…6 There is little information available about the value of MPV on risk prediction and data on the effects of chemotherapy on this platelet index are contradictory. Indeed, MPV has been reported to increase after tamoxifen adjuvant therapy of breast cancer patients 7 which led some authors to solicit studies to assess the need and timing of anti-platelet drugs if elevated MPV is found in tamoxifen-treated patients. 8 On the other hand, MPV was significantly reduced by antiangiogenic treatment of metastatic colon cancer, a condition known to increase thromboembolic risk.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of mean platelet volume as a predictive marker for cancer-associated venous thromboembolism during chemotherapy

et al. 2014

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Mean platelet volume has been proposed as a predictor for venous thromboembolism in cancer. We, therefore, investigated the effects of different anti-cancer drugs on mean platelet volume in order to assess its possible value in the risk prediction of a first thromboembolic episode in cancer outpatients during treatment. Pre-treatment mean platelet volumes were retrospectively evaluated in 589 ambulatory patients at the beginning of a new chemotherapy regimen. Moreover, serial changes were evaluated at baseline and before each chemotherapy cycle on 385 of the 589 patients who consented to have additional blood withdrawals during treatment. Cox proportional hazards survival analysis demonstrated a 2.7 hazard ratio (P=0.01) of developing a first venous thromboembolic episode during chemotherapy for patients with baseline mean platelet volumes below the 10 th percentile (<7.3 fL). This index significantly declined during the first three months of chemotherapy (-6%; P<0.0001) reverting to baseline at the end of treatment. Multivariate regression analysis showed that normal baseline volumes (P=0.012) and platinum-based regimens (P=0.017) were both independent predictors of mean platelet volume decline during chemotherapy which, in turn, was associated with a 2.4 hazard ratio (P=0.044) of venous thromboembolism. In conclusion, low pre-chemotherapy mean platelet volume might be regarded as a predictor of increased venous thromboembolism risk in cancer patients and chemotherapy further decreases platelet volumes, possibly due to drug-induced platelet activation and destruction. Changes in mean platelet volumes during chemotherapy might provide additional information on thromboembolic risk of patients treated with anti-cancer drugs, particularly platinum compounds. Evaluation of mean platelet volume as a predictive marker for cancer-associated venous thromboembolism during chemotherapy

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Mean platelet volume increase after tamoxifen, but not after anastrazole in adjuvant therapy of breast cancer

Abstract: We found increased MPV after tmx treatment, but did not after anastrazole treatment. The advanced studies which explore biological significance of high MPV in breast cancer patients used endocrine therapy, should be established.

Cited by 11 publications

References 16 publications

Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer

Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer

Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer

Evaluation of mean platelet volume as a predictive marker for cancer-associated venous thromboembolism during chemotherapy

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