Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer

Abstract

Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related mortalities worldwide. Platelets play an important and multifaceted role in cancer progression. Elevated mean platelet volume (MPV) detected in peripheral blood has been identified in various types of cancer. In the present study, we investigated the application value of MPV in early diagnostic and prognostic prediction in patients with resectable gastric cancer. In total, 168 patients with resectable gastric cancer were included and separated into the gastric cancer and healthy control groups according to median pre-operatic MPV value (MPV low, <10.51 or MPV high, ≥10.51). The results showed that the pre-operatic MPV level was significantly higher in gastric cancer patients compared with the healthy subjects. Low pre-operatic MPV level correlated with improved clinicopathological features, including decreased depth of invasion, less lymphonodus metastasis and early tumor stage. The Kaplan-Meier plots showed that the patients with higher pre-operatic MPV had decreased overall survival (OS) and disease-free survival (DFS). Surgical tumor resection resulted in a significant decrease in the MPV level. The patients whose MPV level decreased following surgery had an improved OS. Multivariate Cox regression analysis revealed that the depth of invasion, lymphonodus metastasis, American Joint Committee on Cancer (AJCC) stage, and changes in MPV following surgery were prognostic factors affecting OS, and the AJCC stage and pre-operatic MPV were prognostic factors affecting DFS. In conclusion, MPV measurement can provide important diagnostic and prognostic results in patients with resectable gastric cancer.

Utility of complete blood count parameters to detect premature ovarian insufficiency in cases with oligomenorrhea/amenorrhea

“…On the other hand, as the estrogen concentration increases, the anti‐inflammatory pathway becomes active . To date, the relationship between many types of cancer and MPV has been investigated . All authors reported that MPV could be used as a cheap, non‐invasive marker for cancer diagnosis and prognosis in these publications.…”

“…7 To date, the relationship between many types of cancer and MPV has been investigated. [20][21][22][23][24][25][26] All authors reported that MPV could be used as a cheap, non-invasive…”

The angiotensinogen gene polymorphism, lifestyle factors, associated diseases and gastric areas of inflammatory and preneoplastic lesions in a Romanian sample of patients

“…The research performed by Shen XM. et al in a case-control study on 168 patients with resectable gastric cancer showed that the pre-operatic mean platelet volume (MPV) was significantly higher in patients with gastric cancer compared with the healthy control group and a low pre-operatic MPV level and antiplatelet therapy independently related to better histopathological features and improved overall survival in gastric cancer patients (19). On the one hand, there is a concordance of our findings regarding that NSAIDs and antiplatelet therapy was not associated with the occurrence of inflammatory or premalignant gastric lesions (p>0.05) and the data described in the literature which demonstrate that regular use of non-selective NSAIDs, including aspirin, is an effective chemopreventive strategy for the development of gastric cancer.…”

Lower mean platelet volume predicts poor prognosis in renal cell carcinoma

“…Mean platelet volume (MPV), the most commonly used index of platelet size, is a surrogate marker of platelet activation 10 . Altered MPV levels were observed in gastric cancer, ovarian cancer, lung cancer, colon cancer, and breast cancer 11 – 14 . However, its clinical implications in RCC have not been reported.…”