Mean platelet volume in patients with non-alcoholic fatty liver disease

Abstract

Mean platelet volume (MPV) is an indicator of platelet activation. Platelet activation and aggregation are central processes in the pathophysiology of coronary heart disease. Non-alcoholic fatty liver disease (NAFLD) is present up to one-third of the general population and the majority of patients with cardio-metabolic risk factors such as abdominal obesity, type 2 diabetes and other components of the metabolic syndrome (MS). The aim of the current study was to investigate the MPV in patients who had NAFLD. MPV values of the patients with NAFLD and of the patients without fatty liver disease were compared. NAFLD patients had significantly higher body mass index compared to the control cases. Among biochemical variables, fasting plasma glucose and triglyceride were significantly higher in the NAFLD group. NAFLD cases also had lower platelet count and higher MPV (10.43 +/- 1.14 vs. 9.09 +/- 1.25; p < 0.001, respectively). MPV was positively correlated with AST (r: 0.186, p < 0.042), ALT level (r: 0.279; p 0.002) and the presence of NAFLD (0.492; p < 0.001) but negatively correlated with platelet number (r: -0.26; p 0.004) and creatinine (r: -0.255; p 0.005). In logistic regression analysis (age, gender, NAFLD, body mass index, high-density lipid (HDL) cholesterol, systolic and diastolic blood pressure, triglyceride and fasting plasma glucose were used as covariates) only NAFLD was found to be the independent predictor of MPV (Odds Ratio (OR) 21.98) [95% confidence interval (CI): 2.404-201.048; p: 0.006]. We have shown for the first time in the literature that, patients with NAFLD have higher MPV. It may have prognostic value in NAFLD patients indicating a possible cardiovascular disease (CVD) risk increase.

Alcoholic fatty liver disease and alcoholic liver cirrhosis may be differentiated with mean platelet volume and platelet distribution width

“…We read with interest the article by Ozhan and colleagues on mean platelet volume in patients with non-alcoholic fatty liver disease [1]. In this article, they stated that mean platelet volume (MPV) was significantly increased in patients with non-alcoholic fatty liver disease (NAFLD) compared to control subjects.…”

A review of the association of mean platelet volume and red cell distribution width in inflammation

“…35 Another report has been suggested their findings. 36 MPV has been reported to be increased in infectious conditions; such as chronic prostatitis, 6 hepatic 5 and pulmonary 37 hydatid cyst disease.…”

Mean platelet volume in Korean patients with hepatic diseases

“…MPV has been studied in various disease groups other than hematologic disease such as cardiovascular and rheumatic diseases [2][3][4][5]. It has been also investigated in several hepatic diseases and showed significant differences in these disease entities [1,[6][7][8][9][10]. Recently, we read a series of interesting articles about MPV in various hepatic diseases [6,8,10].…”

“…It has been also investigated in several hepatic diseases and showed significant differences in these disease entities [1,[6][7][8][9][10]. Recently, we read a series of interesting articles about MPV in various hepatic diseases [6,8,10]. In this study, we planned to investigate this platelet index in Korean patients with chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC) accompanying increased alpha-fetoprotein (AFP).…”