Mean Platelet Volume in Depression and Anxiety Disorder- a Hospital Based Case-control Study

Abstract

Introduction: Depression and anxiety disorder are the common mental disorders. Serotonin ) is a well-established neurotransmitter in the central nervous system (CNS). It has a role in the anxiety, depression, appetite, motor, cognitive and autonomic functions, platelet aggregation and regulation of vascular tone. As the CNS is difficult to access, peripheral platelet models are widely used as the indicators of central 5-HT metabolism; moreover, they are known to reflect central serotonergic function. Mean platelet volume (MPV) is contemplated as the marker of platelet function. It is a measure of platelet size and a good indicator of platelet activity. In this backdrop the current study was carried out to evaluate the MPV in depression and anxiety disorders. Methods: Consecutive 90 depressive disorder patients, 76 anxiety disorder patients, diagnosed according to DSM 5 criteria and 49 healthy control subjects were selected for the study. Hamilton

Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

“…In high grade inflammatory disease, MPV levels negatively correlated with inflammation (29)(30)(31) however, MPV levels found to be increased in low grade inflammatory diseases such as embolism and infective endocarditis (21,32). MPV was also investigated in psychiatric disorders such as bipolar disorder, depression, anxiety disorder, panic disorder, suicide attempt, and ADHD (23,(33)(34)(35)(36). In this study, MPV and BASO levels were found to be high, especially in boys, but no significant difference was observed in other inflammatory and hematological markers.…”

Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities

“…Other epidemiological studies investigated the relation between MDD and platelets by making use of platelet parameters commonly tested, like mean platelet volume (MPV) and Plt. A positive association between MPV and MDD was reported in a Turkish population sample (N = 2286, 287 cases) [ 144 ], and later replicated in a study comparing 103 MDD patients and 106 controls [ 145 ], as well as in a hospital-based study (90 cases vs. 49 controls) [ 146 ]. However, these studies revealed contrasting evidence of association between Plt and MDD status: while Bondade and colleagues observed an increased Plt in depressed patients [ 146 ], Cai et al found no statistical evidence supporting that finding [ 145 ].…”

“…A positive association between MPV and MDD was reported in a Turkish population sample (N = 2286, 287 cases) [ 144 ], and later replicated in a study comparing 103 MDD patients and 106 controls [ 145 ], as well as in a hospital-based study (90 cases vs. 49 controls) [ 146 ]. However, these studies revealed contrasting evidence of association between Plt and MDD status: while Bondade and colleagues observed an increased Plt in depressed patients [ 146 ], Cai et al found no statistical evidence supporting that finding [ 145 ]. They reported a positive association between MDD and plateletcrit (PCT), i.e., the product of MPV and Plt, which represents the total mass occupied by platelets in the blood [ 145 ].…”

“…Sex effect on the platelet-MDD association has been largely neglected in previous studies [ 144 , 145 , 146 ]. To this end and for the purpose of this review, we made used of the Moli-sani cohort to investigate the influence of sex on the link between depression and platelet indices.…”

“…A summary of shared associated platelet markers among MDD and its comorbidities is reported in Table 2. [146], PanDis [168,169], GAD [146], ASD [170], ADHD [171,172] ↓ in GAD [173] No association with MDD [145], Depressive Symptoms with MI [174], AD [175], PD [175,176], PanDis [177,178], ADHD [171,172,179,180] MPV ↑ in MDD [144][145][146][147], Depressive Symptoms [150], post-Ischemic Stroke depression [181,182], AD [175,183], PD [175], PanDis [177,184,185], GAD [146,173], ADHD [171,179,180,186] ↓ in VaD patients [187] and in AD [187,188], MCI [188], PanDis [168,169,178] Negative correlation with PD progression stage (Hoehn and Yahr score…”