Mean platelet volume in children with attention deficit hyperactivity disorder

Yorbık, Özgür; Mutlu, Caner; Tanju, İlhan Asya; Celik, Dincer; Özcan, Ömer

doi:10.1016/j.mehy.2014.01.001

Cited by 18 publications

(23 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies comparing MPV between ASD patients and controls did not find a statistically significant difference [Bailey et al, 1998;Buitelaar, 2014;Kemper & Bauman, 1998]. There was a study that found increased MPV when comparing 70 children with Attention Deficit Hyperactivity Disorder and 41 healthy controls [Yorbik, Mutlu, Tanju, Celik, & Ozcan, 2014]. When we compared the MPV values between the two groups, we did not find a significant difference, as in previous studies.…”

Section: Discussionsupporting

confidence: 58%

Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

et al. 2019

View full text Add to dashboard Cite

Changes related to the serotonin system play a key role in the etiology of autism spectrum disorder (ASD). Although we know that platelets are associated with the serotonin system, their relation to ASD has not yet been elucidated. In this study, we aim to investigate platelet parameters in children with ASD. Forty patients with ASD according to Diagnostic and Statistical Manual of Mental Disorders 5 (DSM‐5) and 30 healthy controls were included in the study. A complete blood count was done to measure parameters relating to platelet morphology. Moreover, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were evaluated. Lastly, platelet functions were assessed with a platelet functions analyzer 100 (PFA‐100) device by measuring collagen‐ADP and collagen‐epinephrine (EPI) closure times. There was not a significant difference between the groups in terms of platelet count, mean platelet volume (MPV), platelet distribution width, plateletcrit, PT, or aPTT parameters for ASD patients when compared to the control group (P > 0.05). However, MPV in severe ASD, as quantified by the Childhood Autism Rating Scale, was found to be significantly lower when compared to mild to moderate ASD (P = 0.047). Moreover, in terms of platelet functions, the elongation in collagen‐ADP and collagen‐EPI closure times were significantly higher for the ASD group (P = 0.044). These results may suggest an impairment in platelet functions rather than in platelet morphology for children with ASD. Considering these results, further investigation of thrombocyte functions in the ASD may lead to a better understanding of the pathogenesis of ASD and to the development of our limited knowledge of this disorder. Autism Res 2019, 12: 1069–1076. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Serotonin is a chemical that is found in brain as wells as in blood cells that function in blood clotting in the human body. There are problems related to serotonin in brains of people who have autism. Thus, blood clotting cells may also be affected in people who have autism. In this study, we compare blood clotting functions of children with autism with that of healthy controls.

show abstract

Section: Discussionsupporting

confidence: 58%

Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Yorbik et al . reported significantly higher MPV values in children with ADHD than in an HC group . In that study, the increased MPV values were attributed to the underlying mechanism of the relation between ADHD and cardiovascular disease.…”

Section: Discussionmentioning

confidence: 72%

“…[30][31][32][33][34] Yorbik et al reported significantly higher MPV values in children with ADHD than in an HC group. 41 In that study, the increased MPV values were attributed to the underlying mechanism of the relation between ADHD and cardiovascular disease. Similarly, in the current study, MPV values were found to be higher in the ADHD group than in the HC group.…”

Section: Discussionmentioning

confidence: 87%

Evaluation of the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as inflammatory markers in children with attention‐deficit hyperactivity disorder

Avcıl

2018

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…In the literature, there has been only 1 study assessing the association between MPV and ADHD [20]. Our study may be a contribution to the literature on this subject.…”

Section: Discussionmentioning

confidence: 73%

“…The partial correlation analysis showed that vitamin D particularly had an effect on MPV. The only study in the literature assessing the association between ADHD and MPV is by Yorbik et al [20], who found increased levels of MPV in children aged 6–16 years and adolescents with ADHD, but concluded that the reason for and the importance of increased MPV should be clarified by further studies. In our study, we found no association between MPV and ADHD or ASD.…”

Section: Discussionmentioning

confidence: 99%

Association of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders with Mean Platelet Volume and Vitamin D

et al. 2017

View full text Add to dashboard Cite

BackgroundThe purpose of this study was to assess the values of the mean platelet volume (MPV) in children with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASDs) to determine the risk of cardiovascular disease in these 2 disorder groups.Material/MethodsThe study included a total of 79 patients with ADHD or ASDs and controls in the Van region of Turkey. The control group included subjects of matching age and sex with no ADHD, ASDs, or chronic disease and taking no vitamins. The hematological parameters of the patients, including MPV, vitamin B12, and vitamin D, were assessed.ResultsThe study included a total of 79 children and adolescents aged 2–18 years (32 females and 47 males). Of the patients, 36 were in the ADHD group, 18 in the ASDs group, and 25 in the control group. There was no statistically significant difference in hematological parameters between the groups, but there were significant differences in terms of vitamin D and vitamin B12. The patient groups showed lower levels of vitamin B12 and vitamin D. In the ADHD group, there was a negative correlation between both vitamins and MPV (p<0.05). Partial correlation analysis of the ADHD group showed that MPV in particular was negatively correlated to vitamin D, and not to vitamin B12 (p: 0.03).ConclusionsBoth ADHD and ASDs may accompany increased risk for cardiovascular disease due to the presence of vitamin B12 and D deficiency and their own characteristics. Therefore, these disorders should be closely followed up.

show abstract

Mean platelet volume in children with attention deficit hyperactivity disorder

Cited by 18 publications

References 51 publications

Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

Evaluation of the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as inflammatory markers in children with attention‐deficit hyperactivity disorder

Association of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders with Mean Platelet Volume and Vitamin D

Contact Info

Product

Resources

About