Mean platelet volume as a marker of increased cardiovascular risk in patients with nonalcoholic steatohepatitis

Alkhouri, Naim; Kistangari, Gaurav; Campbell, Carla; López, Rocío; Zein, Nizar N.; Feldstein, Ariel E.

doi:10.1002/hep.24721

Cited by 49 publications

(38 citation statements)

References 27 publications

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“…Previous studies have suggested an increased activity of platelets in patients with the metabolic syndrome [12,13] and in patients with NAFLD [14,[32][33][34], which might contribute to their increased risk of thrombosis. However results from these studies are inconsistent, most of these studies are limited by their relative small sample size, and use indirect markers of platelet activation (e.g., mean platelet volume).…”

Section: Discussionmentioning

confidence: 98%

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Preserved hemostatic status in patients with non-alcoholic fatty liver disease

Potze

Siddiqui

Boyett

et al. 2016

Journal of Hepatology

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Section: Discussionmentioning

confidence: 98%

“…Platelet hyperactivity has also been implicated as a contributor of the increased risk of cardiovascular disease in patients with the metabolic syndrome [12][13][14], but its role in NAFLD remains unclear [3].…”

Section: Introductionmentioning

confidence: 99%

Preserved hemostatic status in patients with non-alcoholic fatty liver disease

Potze

Siddiqui

Boyett

et al. 2016

Journal of Hepatology

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“…[5] NAFLD is a major liver disease and is associated with T2 DM and with increased cardiovascular risk. [1] It is a cause for progressive and chronic liver injury. [6] Past studies of NAFLD were based on abdominal ultrasound, magnetic resonance spectroscopy and liver biopsies.…”

Section: Discussionmentioning

confidence: 99%

“…[1] NAFLD accounts for 30% of population in developed countries [2] and is associated with enhanced cardiovascular risk. [1] Platelets play a vital role in hemostasis and mean platelet volume (MPV) is a measure of average size and platelet activity. [3] Larger platelets are more thrombogenic and contribute to atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume in Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus - A Marker of Cardiovascular Risk

Arundhathi¹,

S²,

Gandham³

2016

Int J of Biomed & Adv Res

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Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease associated with diabetes and cardiovascular risk. Platelets play a vital role in hemostasis and mean platelet volume (MPV) is a measure of average size and platelet activity. Larger platelets are highly thrombogenic. Increase in MPV is well documented in diabetes mellitus (DM). Hence, MPV can be used as simple and cost-effective hematological parameter for predicting cardiovascular events in metabolic syndrome. The present study was conducted to study significance of MPV in NAFLD in type 2 DM (T2 DM). Materials & Methods:A case-control study was conducted on 97 T2 DM patients. They were divided into: group 1 which included T2 DM patients without NAFLD and group 2 with T2 DM patients with NAFLD. Healthy 78 individuals were taken as controls. Serum was used for estimation of fasting and post-prandial blood sugar (FBS & PPBS) and liver function test (LFT). EDTA anticoagulated blood was used for estimation of mean platelet volume (MPV). Results: Among 97 T2 DM patients, 62 were males (63.9%) and 35 were females (36%). Liver size, liver enzymes such as aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) were significantly increased in T2DM patients compared to controls and same were significantly increased in T2DM patients with NAFLD compared to those without NAFLD. MPV was found to be increased in T2 DM patients compared to controls. It was also noted to be increased in T2 DM patients with NAFLD compared to T2 DM patients without NAFLD but there was no statistical significance. Conclusion: MPV should be included as screening test to predict cardiovascular events in T2 DM patients with NAFLD.

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“…Nevertheless, the level of MPV on NAFLD remains controversial. While some studies have shown increased MPV values in patients with NAFLD [7,8], others have reported no change [9,10]. Previous studies which have reported increased MPV values in patients with NAFLD, patients were enrolled according to ultrasound criterias [8].…”

mentioning

confidence: 99%