Mean platelet volume and the extent of coronary artery disease: Results from a large prospective study

The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease

“…In the present study, the plasma PCSK9 level was related to the PLT and PCT in the patients regardless of whether they had single-, two-or multi-vessel disease, but was particularly strong in patients with two diseased vessels ( Table 3). This result might suggest that the potential interaction between PCSK9 and platelets responded differently to the various degrees of CAD [14][15][16] . After performing the univariate and multivariate logistic analyses regarding the independent effects of PCSK9 and the platelet indices on the severity of CAD (Table 4), the PCSK9 levels were found to be significantly associated with multivessel CAD (odds ratio [OR]: 2.282, 95% confidence interval [CI] 1.063-4.900; p 0.05), but the four platelet indices showed no significant association with the severity of CAD in the present study population.…”

“…The MPV data therefore might not be helpful at present, as they are still dependent on the careful control of laboratory procedures, and the standardization of platelet studies is an emerging topic of discussion. Moreover, there have been conflicting data about the importance of MPV in patients with stable CAD 15,16) . Additionally, the platelet volume is mainly number of diseased vessels.…”

Association between mean platelet volume and hypertension incidence

“…In fact, over the past decade, an accumulating body of evidence has demonstrated that MPV is a predictive marker for stroke 11 and coronary artery disease. 12 Platelet count and platelet parameters such as platelet distribution width are usually measured along with MPV, and significant differences have been observed in thrombosis and cardiovascular events as well as MPV. 13,14 However, no reports concerning these two indices have been found for hypertension.…”

Biomarkers and Coronary Atherosclerotic Burden and Activity as Assessed by Coronary Angiography and Intra-Coronary Imaging Modalities

“…This study showed that MPV was not related to platelet aggregation, the extent of CAD and carotid intima-media thickness. Thus, according to this study (De Luca et al, 2009) this parameter cannot be considered as a marker of platelet reactivity or a risk factor for CAD. This is the largest study so far conducted to investigate the relationship between MPV and CAD.…”

“…Confirming the importance of MPV, several additional reports have demonstrated that MPV was associated with impaired myocardial perfusion and clinical outcome after primary angioplasty. De Luca et al (De Luca et al, 2009) measured MPV in 1411 consecutive patients undergoing coronary angiography. Significant CAD was defined as stenosis >50% in at least 1 coronary vessel.…”