Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: A case control study

Abstract

Background:Coronary artery disease is mainly caused by atherosclerosis and its complications. Platelets and their activity have an important role in initiation of atherosclerotic lesions and coronary thrombus formation. Larger platelets are enzymatically and metabolically more active and have a higher potential thrombotic ability as compared with smaller platelets.Aims:To study the changes in platelet volume indices and platelet count in acute myocardial infarction, stable coronary artery disease and compare them with controls to assess their usefulness in predicting coronary events.Materials and Methods:This was a comparative study of 128 subjects; 39 patients with acute myocardial infarction (AMI), 24 patients with stable coronary artery disease (SCAD) and 65 controls. Venous sample were drawn from AMI subjects on admission (within 4 hours of chest pain) and collected in standardized EDTA sample tubes. Platelet count and volume indices were assayed within 30 minutes of blood collection, using Sysmex KX21-N autoanalyzer. Venous samples were also drawn from SCAD on who were admitted for angiography and subject attending routine checkups.Results:The mean platelet volume was significantly higher in patients with AMI (9.65 ± 0.96) as compared to SCAD (9.37 ± 0.88) and controls (9.21 ± 0.58). The best cut-off values for MPV when predicting AMI and SCAD in patients were 9.25 fl (sensitivity 56.4%; specificity 45.9%) and 9.15 fl (sensitivity 54.2%; specificity 42.23%), respectively.Conclusions:Measurements of MPV may be of some benefit in detecting those patients at higher risk for an AMI and CAD.

Platelet volume indices in acute coronary syndrome - a case control study

“…The Thrombus leads to partial or complete coronary artery occlusion which in turn leads to myocardial ischemia and various clinical manifestations ranging from unstable angina (UA) to acute myocardial infarction (AMI). 1,2 Platelets play a crucial role in pathogenesis of atherosclerotic complications, contributing to the thrombus formation after plaque rupture. 3,4 Increased platelet reactivity as well as shortened bleeding time is associated with increased platelet volume.…”

Mean platelet volume as diagnostic and therapeutic marker of risk and prognosis of heart disease

“…Studies have reported platelet volume to be significantly higher among acute myocardial infarction patients than control subjects. 13,14 An elevated MPV correlates with poor clinical outcomes among survivors of myocardial infarction in the era of thrombolysis and an impaired response to thrombolysis in those with ST segment elevated myocardial infarction. 15 Elevated MPV has also been reported has also been reported to carry worse prognosis in terms of poor angiographic reperfusion and higher six months mortality following primary percutaneous coronary intervention (PCI) and also correlates with subsequent mortality and nonfatal myocardial reinfarction.…”

Platelet Volume Indices and Platelet Count in Patients with Acute Coronary Syndrome – Case control study

“…Few studies have shown that platelet volume indices vary between different ethnicities. [17], [18] Few medications, obesity, diabetes influence platelet indices. There is temporal increase in MPV values in EDTA anticoagulated sample.…”