Mean platelet volume and mean platelet volume/platelet count ratio in risk stratification of pulmonary embolism

Yardan, Türker; Meriç, Murat; Katı, Celal; Çelenk, Yıldıray; Atıcı, Atilla Güven

doi:10.1016/j.medici.2016.03.001

Cited by 23 publications

(20 citation statements)

References 24 publications

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“…Most reports have shown that reduced MPV and/or MPV/P were linked to unsatisfactory prognosis in several carcinomas. 20,21 However, in advanced NSCLC studied by Omar et al, 22 they found elevated MPV and MPV/P could be an indicator of poor prognosis regarding OS, which is consistent with our current study. We conclude that this disparity maybe due to differing choice in cut-off points and in the type of carcinomas studied.…”

Section: Ta B L E 2 (Continued)supporting

confidence: 92%

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Lau

Hsueh

Chen

et al. 2020

Clinical Otolaryngology

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Objectives To investigate the prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma (HPSCC). Methods The data of 247 eligible advanced HPSCC patients were reviewed retrospectively. Pretreatment haematological parameters were categorised into two groups based on the result of X‐tile, and several variates were assessed using chi‐square test, Kaplan‐Meier method, Cox univariate and multivariate analysis. Results The optimal cut‐off points of 171.4 for PLR, 260 × 109/L for platelet, 10.4 fL for mean platelet volume (MPV) and 16.5% for platelet distribution width were defined. The haematological parameters PLR and MPV, postoperative metastasis and internal jugular vein invasion were statistically significant in OS and DFS analyses (P < .05). The high PLR (>171.4) or high MPV (>10.4 fL) was significantly associated with worse OS and DFS (P < .05). Conclusions The preoperative levels of PLR and MPV could be considered as independent prognostic predictors in patients with advanced HPSCC.

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Section: Ta B L E 2 (Continued)supporting

confidence: 92%

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Lau

Hsueh

Chen

et al. 2020

Clinical Otolaryngology

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“…20 Several studies suggested its correlation with right ventricular (RV) dimensions and the severity of RV dysfunction. 15,21,22 Nevertheless, these studies were not consistent so far and some studies failed to find a correlation between MPV and disease severity. 21,23 In this study, the simplified PESI outperformed the platelet indices in prognosticating patients with acute PTE.…”

Section: Discussionmentioning

confidence: 93%

“…This can be attributed to the consumption of platelets for thrombus formation and a compensatory production of larger platelets from megakaryocytes in the bone marrow. 22,25 Previous studies have showed a relationship between PLR and a high risk of in-hospital mortality in patients with acute PTE and found it to be correlated with established risk scores (e.g. simplified PESI).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Ghaffari

Parvizian

Pourafkari

et al. 2020

J Cardiovasc Thorac Res

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Introduction: Given the role of platelets in thrombus formation, markers of platelet activation may be able to predict outcomes in patients with acute pulmonary thromboembolism (PTE). Methods: In a prospective cohort study, 492 patients with acute PTE were enrolled. Patients were evaluated for platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and platelet-lymphocyte-ratio (PLR), as well as for the simplified Pulmonary Embolism Severity Index (PESI) risk score. The primary endpoint was in-hospital all-cause mortality. Major adverse cardiopulmonary events (MACPE, composite of mortality, thrombolysis, mechanical ventilation and surgical embolectomy during index hospitalization) and all-cause death during follow-up were secondary endpoints. Results: MPV, PDW and PLR were 9.9±1.0 fl, 13.5±6.1%, and 14.7±14.5, respectively, in the total cohort. Whilst MPV was higher in those with adverse events (10.1±1.0 vs 9.9±1.0 fl; P = 0.019), PDW and PLR were not different between two groups. MPV with a cut-off point of 9.85 fl had a sensitivity of 81% and a specificity of 50% in predicting in-hospital mortality, but it had lower performance in predicting MACPE (Area under the curve: AUC 0.58; 95%CI 0.52-0.63) or long-term mortality (AUC 0.54; 95% CI 0.47-0.61). The AUC for all these three markers were lower than the AUC calculated for the simplified PESI score (0.80; 0.71-0.88). Conclusion: Platelet indices had only fair-to-good predictive performance in predicting in-hospital all-cause death. Established PTE risk scoring models such as simplified PESI outperform these indices in predicting adverse outcomes. Article info TUOMS P R E S SPlatelets indicies in acute pulmonary thromboembolism

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“…PDW is accepted as a more specific marker of platelet activation because it does not increase in response to platelet swelling. There are some studies in the literature regarding the relationship of PDW with PTE [15,26]. Sevuk et al reported that PDW values were higher in patients who developed acute PTE after DVT than those who did not [27].…”

Section: Discussionmentioning

confidence: 99%

Does the Platelet Index Have a Guiding Role in the Association of Cancer and Pulmonary Thromboembolism?

Öcal¹,

Öcal²

2020

Multidiscip Cancer Investig

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Introduction: The diagnostic value of the D-dimer test varies with variable platelet numbers and functions in patients suffering from cancer and concomitant pulmonary thromboembolism (PTE). This requires easy and reliable evaluation tests. In this study, we aimed to investigate the hypothesis that platelet functions may be more guiding in the prediction and diagnosis of PTE rather than the number of platelets in cancer pa- tients. Methods: The clinical, laboratory and radiological findings of all patients diagnosed with PTE were retrieved, retrospectively. Comparisons were performed between “can- cer-free” and “cancer” patients. The patients were also evaluated according to their active and remission status. Results: The data of 232 patients with PTE were reviewed. 172 patients were cancer- free and 60 were diagnosed with cancer. The mean values of D-dimer, mean platelet volume (MPV) and platelet distribution width (PDW) were found to be significantly higher in patients with cancer (P=0.015, P=0.026, and P=0.023; respectively). On the other hand, mean platelet counts were significantly higher in patients without cancer (P=0.05). It was also observed that the mean values of D-dimer, Troponin-I, MPV, and PDW were found to be significantly higher in patients with active cancer (P=0.05, P=0.044, P=0.05, and P=0.042; respectively). However, the mean platelet counts were significantly higher in patients with cancer who were in remission (P=0.05). Conclusions: The morphological characteristics of the platelets are more determinant than the number of platelets in cancer patients with PTE. Platelet indexes such as MPV and PDW may be useful in the prediction, diagnosis, and follow-up of PTE in patients with cancer.

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Mean platelet volume and mean platelet volume/platelet count ratio in risk stratification of pulmonary embolism

Abstract: MPV and MPV/P were found to be associated with RV dysfunction and clinical severity in acute PE. Low MPV and MPV/P levels may be an indicator of low risk and, high WBC levels may be an indicator of high risk in patients with acute PE. RDW levels may not reflect severity of acute PE.

Cited by 23 publications

References 24 publications

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Does the Platelet Index Have a Guiding Role in the Association of Cancer and Pulmonary Thromboembolism?

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