Mean platelet volume and its close relationship with septic hospital infections

Abstract

Introduction: the average platelet volume is obtained from the blood count, considered as a low-cost and easily accessible biomarker, available in all medical units. It is considered a biomarker that indicates inflammation, thrombosis, and endothelial injury, while foreign studies have shown encouraging advances in diseases with prothrombotic and immunoinflammatory components. Objective: to establish the relationship of mean platelet volume with hospital septic infections. Methodology: information sources available in the Pubmed, Medicgraphic, and SciELO databases were consulted, as well as the Google Scholar search engine. Publications in both English and Spanish were included, with a maximum of 5 years prior to the topic of interest. Results: original articles were analyzed in which populations of neonates and adults with sepsis are analyzed. Populations of newborns reflected a high value of MPV in the first 24 hours, proving to be an early predictive marker in the diagnosis of neonatal sepsis, while population studies in adults reflected a much higher MPV in septic patients who later died. in relation to those who survived, being also considered a predictor of mortality. Conclusions: it is evident that MPV is closely related to sepsis since it increases progressively during infection, constituting a biomarker for early prediction and poor prognosis in sepsis.