Mean platelet volume and its relation to insulin resistance in non-diabetic patients with slow coronary flow

Elsherbiny, Islam A.; Shoukry, A; Tahlawi, Mohammad El

doi:10.1016/j.jjcc.2011.11.009

Cited by 26 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chou et al reported that serum UA levels were more strongly associated with insulin resistance in females than in males [29]. Insulin resistance contributes to increased platelet activation and MPV [30]. Thus, one possible explanation for the observed gender differences in the present study is that insulin resistance may play a role in the etiology of the relationship between UA and MPV.…”

Section: Discussionmentioning

confidence: 50%

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

et al. 2013

View full text Add to dashboard Cite

Mean platelet volume (MPV) can reflect platelet activity. Furthermore, high MPV is associated with thrombogenic activation and increased risk of cardiovascular disease. MPV of subjects with hypertension, hyperglycemia, or hyperlipidemia is higher compared with that of normal subjects. In contrast, the relationship between MPV and uric acid (UA) is poorly understood. The present study aims to evaluate the relationship between MPV and serum UA levels in both genders. We retrospectively studied 2104 Japanese subjects (1221 males, 883 females) undergoing general health examinations. Age, gender, body mass index (BMI), blood pressure (BP), smoking habits, alcohol intake, lipid profiles, fasting plasma glucose (FPG), high-sensitivity C-reactive protein, serum UA levels and MPV were evaluated. On the basis of the serum UA levels, the subjects were categorized into the following tertiles: 1st (Q1), 2nd (Q2), and 3rd (Q3). In males, a univariate analysis revealed that age, FPG and systolic and diastolic BP were significantly associated with MPV; in addition to these parameters, in females, UA and LDL-cholesterol correlate with MPV. Furthermore, in females, a stepwise linear regression analysis showed a significant positive correlation between UA and MPV (β=0.059, p=0.008). MPV in females increased gradually based on the serum UA tertile, despite adjusting for confounding variables (Q1, Q2, and Q3 values were 9.88 ± 0.70, 9.95 ± 0.73, and 10.00 ± 0.77 fL, respectively; p<0.039). The serum UA levels were found to be a key determinant of MPV in females.

show abstract

Section: Discussionmentioning

confidence: 50%

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Rapid resolution of insulin resistance occurs after delivery, suggesting a major contribution from placental hormones. The relationship between MPV and insulin resistance was demonstrated in some studies [20,21]. In vitro and in vivo studies showed that insulin inhibits platelet aggregation and activation in insulin-sensitive subjects.…”

Section: Discussionmentioning

confidence: 97%

Elevated mean platelet volume is associated with gestational diabetes mellitus

İyidir

Değertekin

Yılmaz

et al. 2014

Gynecological Endocrinology

View full text Add to dashboard Cite

The mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Elevated MPV values are associated with larger and more active platelets and perceived as a new independent cardiovascular risk factor. The aim of this study was to determine the MPV in women with gestational diabetes mellitus (GDM) and to determine the correlation of MPV with metabolic parameters in GDM. We retrospectively analyzed 30 women with GDM and 38 body mass index-matched women with healthy pregnancies as controls. MPV and platelet counts were recorded in the third trimester and at postpartum 6-12 months for GDM group and in the third trimester for control group. Third-trimester MPV was significantly higher in GDM group compared to control group (8.8 ± 1.0 versus 8.1 ± 0.7 fl, p = 0.002). In women with GDM, there was a significant decrease in MPV in the postpartum period (8.8 ± 1.0 versus 8.1 ± 0.8 fl, p < 0.001). Fasting plasma glucose levels and glucose area under the curve were positively correlated with third trimester MPV (r = 0.346, p = 0.007 and r = 0.346, p = 0.02, respectively). Our results indicate that MPV is increased in GDM. Monitoring MPV, which is widely available in clinical practice, may potentially identify women who will develop gestational diabetes during pregnancy.

show abstract

“…Arterial thrombosis and the proliferation of thrombi require that a sequence of coagulation reactions as well as platelet deposition occur on the thrombus surface. Adding pharmacologic concentrations of rFVIIa to hemophilic blood markedly increases platelet activation in the absence of tissue factor and decreases the tissue factor-independent APTT and tissue factor-relative prothrombin time [16],[18],[19]. Therefore, the administration of a combination of additional platelets and rFVIIa could significantly improve coagulation reactions, better than a single administration of either platelets or rFVIIa alone.…”

Section: Discussionmentioning

confidence: 99%

Combination use of platelets and recombinant activated factor VII for increased hemostasis during acute type a dissection operations

Wen

Xuan

et al. 2014

J Cardiothorac Surg

View full text Add to dashboard Cite

BackgroundRefractory blood loss is a common problem in surgeries for acute type A aortic dissections. Significant evidence has supported the benefit of using recombinant activated factor VII (rFVIIa) to control of intractable bleeding in patients after cardiac surgery. In this prospective clinical study, we present a novel method to achieve intraoperative hemostasis by using a combination of platelets and rFVIIa during operations for acute type A aortic dissections.MethodsBetween May 2009 and August 2012, 71 patients with acute type A dissections who underwent emergency surgery were prospectively included and allocated to one of the following two intervention groups for hemostasis: 3 units platelets combined with 2.4 mg rFVIIa (n = 25), and conventional methods (n = 46).ResultsThe patients who received the combination of platelets and rFVIIa required fewer transfusions of red blood cells (6.2 ± 3.1 units vs 9.8 ± 2.8 units; p < 0.05), fresh frozen plasma (736.9 ± 178.3 ml vs 1264.3 ± 245.2 ml, p < 0.05), platelet concentrates (3 units vs 5.0 ± 1.8 units, p < 0.001), and cryoprecipitate (2.8 ± 0.9 units vs 8.2 ± 2.3 units, p < 0.05). These patients also required less time for sternal closure (76.9 ± 17.2 min vs 102.3 ± 10.7 min, p < 0.05) compared with the conventional therapy patients. There was no statistically significant difference in the incidence of serious adverse events between these two groups.ConclusionsUsing a combination of platelets and rFVIIa is an effective strategy for achieving hemostasis during acute type A dissection surgery. This hemostatic strategy does not appear to be associated with an increase in postoperative adverse events.Electronic supplementary materialThe online version of this article (doi:10.1186/s13019-014-0156-y) contains supplementary material, which is available to authorized users.

show abstract

Mean platelet volume and its relation to insulin resistance in non-diabetic patients with slow coronary flow

Cited by 26 publications

References 28 publications

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

Elevated mean platelet volume is associated with gestational diabetes mellitus

Combination use of platelets and recombinant activated factor VII for increased hemostasis during acute type a dissection operations

Contact Info

Product

Resources

About