Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

Abstract

Mean platelet volume (MPV) can reflect platelet activity. Furthermore, high MPV is associated with thrombogenic activation and increased risk of cardiovascular disease. MPV of subjects with hypertension, hyperglycemia, or hyperlipidemia is higher compared with that of normal subjects. In contrast, the relationship between MPV and uric acid (UA) is poorly understood. The present study aims to evaluate the relationship between MPV and serum UA levels in both genders. We retrospectively studied 2104 Japanese subjects (1221 males, 883 females) undergoing general health examinations. Age, gender, body mass index (BMI), blood pressure (BP), smoking habits, alcohol intake, lipid profiles, fasting plasma glucose (FPG), high-sensitivity C-reactive protein, serum UA levels and MPV were evaluated. On the basis of the serum UA levels, the subjects were categorized into the following tertiles: 1st (Q1), 2nd (Q2), and 3rd (Q3). In males, a univariate analysis revealed that age, FPG and systolic and diastolic BP were significantly associated with MPV; in addition to these parameters, in females, UA and LDL-cholesterol correlate with MPV. Furthermore, in females, a stepwise linear regression analysis showed a significant positive correlation between UA and MPV (β=0.059, p=0.008). MPV in females increased gradually based on the serum UA tertile, despite adjusting for confounding variables (Q1, Q2, and Q3 values were 9.88 ± 0.70, 9.95 ± 0.73, and 10.00 ± 0.77 fL, respectively; p<0.039). The serum UA levels were found to be a key determinant of MPV in females.

Hematological parameters in adolescents with hyperuricemia

“…Increased insulin resistance and other components of the metabolic syndrome were earlier shown to be associated with increased white and red blood cell count, hemoglobin, and hematocrit, and as a consequence, increased blood viscosity [14]. Our finding of no correlation between serum uric acid and platelet count and mean platelet volume was contrary to other reports [15] Although there is some evidence linking increased white and red blood cell count, hemoglobin, and hematocrit with hyperuricemia, role of confounding variables like chronic inflammation and obesityassociated obstructive sleep apnea cannot be ruled out.…”

The Association Between Hyperuricemia and Hematological Indicators in a Chinese Adult Population

“…Studies had reported a significant correlation between SUA and platelet count and mean platelet volume. 18 In addition, several theories implicated that elevated SUA was a causative factor for increasing platelet reactivity, but SUA levels did not influence platelet aggregation. 17,19 A previous study observed a significant relationship between SUA and mean platelet volume, and this association was stronger in women than men.…”

“…17,19 A previous study observed a significant relationship between SUA and mean platelet volume, and this association was stronger in women than men. 18 Platelet abnormalities occurred with hyperuricemia. Altered platelet kinetics played a role in arterial thrombosis and possibly in the genesis of atherosclerosis.…”

An association of platelet indices with blood pressure in Beijing adults

“…Previous studies have shown that there was a sex effect on the relationship of blood pressure and platelet indices. [18,49–51] Those studies suggested that only partial indicators of platelet indices reflect the disease severity. From our findings, we can suggest that an elevated MPV and PDW might be an indication to recognize the part of platelet activation in the interpretation of the cause of hypertension.…”