Mean Oxygen Saturation during Sleep Is Related to Specific Brain Atrophy Pattern

Marchi, Nicola Andrea; Ramponi, Cristina; Hirotsu, Camila; Haba‐Rubio, José; Lutti, Antoine; Preisig, Martin; Marques‐Vidal, Pedro; Vollenweider, Péter; Kherif, Ferath; Heinzer, Raphaël; Draganski, Bogdan

doi:10.1002/ana.25728

Cited by 37 publications

(33 citation statements)

References 52 publications

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“…Previous research has shown that putamen is involved in sensorimotor activity (45), suggesting an important role in gating respiratory information (46). Consistent with our study, Marchi et al (47) reported that mean oxygen saturation during sleep is correlated with the volume of left putamen. Asthma often attacks during sleep, with a great influence on the oxygen saturation.…”

Section: Relationship Between Variability and Clinical Symptomssupporting

confidence: 92%

Asthma-Specific Temporal Variability Reveals the Effect of Group Cognitive Behavior Therapy in Asthmatic Patients

et al. 2021

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Background: Group cognitive behavior therapy (GCBT) is a successful therapy for asthma. However, the neural biomarker of GCBT which could be used in clinic remains unclear. The temporal variability is a novel concept to characterize the dynamic functional connectivity (FC), which has many advantages as biomarker. Therefore, the aim of this study is to explore the potential difference of temporal variability between asthmatic patients and healthy controls, then determine the different patterns of temporal variability between pre- and post-treatment group and reveal the relationship between the variability and the symptoms improvement reduced by GCBT.Methods: At baseline, 40 asthmatic patients and 40 matched controls received resting-state functional magnetic resonance imaging (fMRI) scans and clinical assessments. After 8 weeks of GCBT treatment, 17 patients received fMRI scans, and assessments again. Temporal variability at baseline and post-treatment were calculated for further analysis.Results: Compared with controls, asthmatic patients showed widespread decreases in temporal variability. Moreover, the variability in both right caudate and left putamen were positively correlated with asthma control level. After GCBT, asthma control level and depression of patients were improved. Meanwhile, compared with pre-GCBT, patients after treatment showed lower variability in left opercular of Rolandic, right parahippocampal gyrus and right lingual gyrus, as well as higher variability in left temporal pole. Variability in regions which were found abnormal at baseline did not exhibit significant differences between post-GCBT and controls.Conclusions: Asthma-specific changes of dynamic functional connectivity may serve as promising underpinnings of GCBT for asthma.Clinical Trial Registration:http://www.chictr.org.cn/index.aspx, identifier: Chi-CTR-15007442.

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Section: Relationship Between Variability and Clinical Symptomssupporting

confidence: 92%

Asthma-Specific Temporal Variability Reveals the Effect of Group Cognitive Behavior Therapy in Asthmatic Patients

et al. 2021

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“…Of interest, the average sleep oxygen saturation correlated with lower brain volumes. In a large population-based study, average oxygen saturation during sleep correlated with lower brain volumes in the hippocampus-amygdala complex and other cortical regions sensitive to low oxygen saturation [41]. These findings suggest that nocturnal oxygen saturation could be a better metric to study brain health in OSA patients.…”

Section: Discussionmentioning

confidence: 78%

Cognitive and Neuroimaging Correlates of the Insomnia Severity Index in Obstructive Sleep Apnea: A Pilot-Study

et al. 2021

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We aim to determine the sleep correlates of age-related brain loss in a sample of middle-aged to older males with obstructive sleep apnea (OSA). We recruited consecutive treatment naïve male patients with moderate to severe OSA from January to November of 2019. We excluded participants if they had dementia, stroke or heart disease. We collected demographic variables and vascular risk factors. We also obtained the insomnia severity index, the Epworth sleepiness scale and the Pittsburgh sleep quality index. We also obtained computerized neurocognitive testing with the go-no-go response inhibition test, Stroop interference test, catch game test, staged information processing speed test, verbal memory test and non-verbal memory test. We derived age and education adjusted domain-specific Z-scores for global cognition, memory, attention, processing speed and executive function. We used brain MRI T1-weighted images to derive total hippocampal and gray matter volumes. Partial correlations evaluated associations between variables from sleep questionnaires (e.g., insomnia severity index score), and polysomnographic variables (the apnea-hypopnea index, average oxygen levels during sleep) with cognitive domains and brain volumes. We examined 16 participants with an age range of 40–76 years, 73% Hispanic/Latino. The mean apnea-hypopnea index was 48.9 ± 25.5 and average oxygen saturation during sleep was 91.4% ± 6.9%. Hypertension was seen in 66% and diabetes mellitus in 27%. We found that the insomnia severity index score and average oxygen levels during sleep had the strongest correlations with brain volumes and cognition. These preliminary findings may aid in developing future strategies to improve age-related brain loss in patients with OSA.

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“…In a large population based study, oxygen levels during sleep correlated with brain volumes in the hippocampusamygdala complex and other cortical regions sensitive to hypoxemia. [42] These findings suggest that nocturnal oxygenation or hypoxemia may serve as better predictors of brain health. In addition, we observed that daytime sleepiness, as measured by the Epworth sleepiness scale (ESS), had positive correlations with the lateral ventricles, suggesting an increment in ventricular volume with increase daytime sleepiness.…”

Section: Discussionmentioning

confidence: 96%

Cognitive and Neuroimaging Correlates of Insomnia Symptoms in Obstructive Sleep Apnea: A Pilot-Study

Ramos¹,

Alperin²,

S³

et al. 2021

Preprint

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We aim to determine the sleep correlates of age-related brain loss in a sample of middle-aged to older males with obstructive sleep apnea. We evaluated consecutive treatment naïve male patients with OSA (AHI≥15 events/hr) without dementia, stroke or heart disease, from January to November of 2019. We collected demographic variables, vascular risk factors, and sleep questionnaires. We also obtained computerized neurocognitive testing with the Go-No-Go Response Inhibition Test, Stroop Interference Test, Catch Game Test, Staged Information Processing Speed Test, Verbal Memory Test and Non-Verbal Memory Test. We derived age and education adjusted domain-specific Z-scores for global cognition, memory, attention, processing speed and executive function. We used brain MRI T1-weighted images to derive total hippocampal and gray matter volumes. Partial correlations evaluated associations between the ISI, AHI, and oxygen level during sleep, with cognitive domains and brain volumes. Sixteen participants, age 40-76 years, 73% Hispanic/Latino, with mean AHI=48.9±25.5 and mean oxygen saturation of 91.4±6.9% during sleep. Hypertension was seen in 66% and diabetes in 27%. We observed that ISI and oxygen level during sleep had strong correlations with brain volumes and cognition. These preliminary findings may aid in developing future strategies to improve age-related brain loss in OSA.

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Mean Oxygen Saturation during Sleep Is Related to Specific Brain Atrophy Pattern

Cited by 37 publications

References 52 publications

Asthma-Specific Temporal Variability Reveals the Effect of Group Cognitive Behavior Therapy in Asthmatic Patients

Asthma-Specific Temporal Variability Reveals the Effect of Group Cognitive Behavior Therapy in Asthmatic Patients

Cognitive and Neuroimaging Correlates of the Insomnia Severity Index in Obstructive Sleep Apnea: A Pilot-Study

Cognitive and Neuroimaging Correlates of Insomnia Symptoms in Obstructive Sleep Apnea: A Pilot-Study

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