Meal patterns and macronutrient intake after peripheral and PVN injections of the α2-receptor antagonist idazoxan

Alexander, Jesline T.; Cheung, W.K.; Dietz, Carsten; Leibowitz, Sarah F.

doi:10.1016/0031-9384(93)90165-c

Cited by 12 publications

(4 citation statements)

References 24 publications

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“…Noradrenaline transmission has different effects. Noradrenaline increases in PVH at the onset of the periods of food intake and stimulates carbohydrate intake through binding to α2 receptors (Alexander, Cheung, Dietz, & Leibowitz, 1993); however, noradrenaline in the NTS-PVH pathway is also a principal mediator of several satiation stimuli (Rinaman, 2011).…”

Section: Homeostatic Systemmentioning

confidence: 99%

Nicotinic Regulation of Energy Homeostasis

Zoli

Picciotto

2012

Nicotine & Tobacco Research

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Introduction: The ability of nicotine, the primary psychoactive substance in tobacco smoke, to regulate appetite and body weight is one of the factors cited by smokers that prevents them from quitting and is the primary reason for smoking initiation in teenage girls. The regulation of feeding and metabolism by nicotine is complex, and recent studies have begun to identify nicotinic acetylcholine receptor (nAChR) subtypes and circuits or cell types involved in this regulation.

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Section: Homeostatic Systemmentioning

confidence: 99%

Nicotinic Regulation of Energy Homeostasis

Zoli

Picciotto

2012

Nicotine & Tobacco Research

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“…[12][13][14] The nutrient selective role of NE in the facilitation of feeding appears to be regulated by α 2 receptors because the antagonist idazoxan selectively increased carbohydrate intake after intra-PVN administration. 35 This corresponds with the dense population of α2 receptors in the PVN 36 and related hypotheses regarding the role of the PVN in energy homeostasis. 37 Because NE transmission in the PVN selectively regulates carbohydrate intake, the present data warrant consideration of whether changes in ethanol intake may reflect energy regulation.…”

Section: Discussionmentioning

confidence: 60%

Norepinephrine and Serotonin Receptors in the Paraventricular Nucleus Interactively Modulate Ethanol Consumption

Hodge

Slawecki

Aiken

1996

Alcoholism Clin & Exp Res

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The homeostatic function of the hypothalamus has long been recognized. In particular, the role of the paraventricular nucleus (PVN) in regulating ingestive behavior has been of interest. Infusions of serotonin and norepinephrine into the PVN are correlated with nutrient selective decreases and increases in consumatory behavior, respectively. Given the wide range of homeostatic functions of the hypothalamus, it is plausible that similar hypothalamic mechanisms may also be involved in the regulation of ethanol intake. This study examined the effects of PVN infusions of serotonin (5-HT) and norepinephrine (NE) on ethanol intake in a 1-hr limited-access two-bottle paradigm. When intake of 6% (v/v) ethanol versus water stabilized, male Wistar rats were implanted with stainless steel guide cannulae aimed at the PVN. After recovery, NE (20, 50, and 100 nmol), 5-HT (5 and 25 nmol), and their combination (NE 50 nmol + 5-HT 5 nmol) were microinjected into the PVN in a volume of 0.5 microliter/side over 1 min. Baseline ethanol intake was approximately 1.0 g/kg and ethanol preference (milliliters ethanol per total milliliters) was approximately 60%. Both 20 and 50 nmol of NE significantly increased absolute ethanol intake by 50% and relative ethanol intake by approximately 30%. Corresponding decreases were observed in water intake. Neither dose of 5-HT when administered alone altered ethanol or water consumption, but the 5-nmol dose of 5-HT attenuated the increase observed after NE (50 nmol) administration. These data demonstrate that NE and 5-HT receptors in the PVN interact in the modulation of ethanol ingestion. This finding suggests that homeostatic regulatory functions of the hypothalamus are involved in ethanol intake, and a perturbation of this system may influence excessive drinking.

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“…For example, the 2 AR agonist clonidine stimulates feeding when infused into the rat hypothalamic paraventricular nucleus by increasing meal size and leaving meal frequency unaffected [175]. Idazoxan, an 2 AR antagonist, reduced meal size either when administered systemically or infused into the paraventriclar nucleus [176]. These authors also reported that clonidine stimulated, and idazoxan reduced, carbohydrate consumption.…”

Section: Noradrenalinementioning

confidence: 89%

Monoamine Receptors in the Regulation of Feeding Behaviour and Energy Balance

Clifton

Kennett²

2006

CNSNDDT

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We evaluate the likely utility of drugs that interact, either directly or indirectly, with monoamine binding receptors for the treatment of obesity. We discuss ligands at dopaminergic, adrenergic, serotoninergic and histaminergic receptors and also drugs that either release or inhibit the reuptake of monoamine neurotransmitters. We review evidence from preclinical studies of receptor distribution and function, together with the consequences of gene deletion in transgenic mouse strains and the results from human studies where these are available. In addition we consider the side effect profiles that would be expected of these potential anti-obesity treatments. We conclude that compounds interacting with 5-HT(2C), 5-HT(6) and histamine H(3) receptors may be of particular interest as specific drug development targets for the treatment of appetite disturbance in obesity.

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Meal patterns and macronutrient intake after peripheral and PVN injections of the α2-receptor antagonist idazoxan

Cited by 12 publications

References 24 publications

Nicotinic Regulation of Energy Homeostasis

Nicotinic Regulation of Energy Homeostasis

Norepinephrine and Serotonin Receptors in the Paraventricular Nucleus Interactively Modulate Ethanol Consumption

Monoamine Receptors in the Regulation of Feeding Behaviour and Energy Balance

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