MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case–control studies

Wang, Jun; Wang, Baocheng; Bi, Jian; Li, Kainan; Jiang, Di

doi:10.1007/s00432-012-1171-9

Cited by 43 publications

(26 citation statements)

References 48 publications

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“…In a meta-analysis published in 2012 that involved 7 studies, MDR1 C3435T polymorphism was significantly associated with increased risk of breast cancer (TT vs CC, OR = 1.66, 95% CI (1.24-2.21) (Wang et al, 2012). A meta-analysis published in 2013 based on 52 studies, included 9 studies that analysed the association of breast cancer and C3435T polymorphism showed similar results [TT vs CC: OR=1.18, 95%CI (0.869-1.621), p=0.001] (Wang et al, 2013b).…”

Section: Discussionmentioning

confidence: 99%

Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan

Abuhaliema¹,

Yousef²,

Elmadany³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan

Abuhaliema¹,

Yousef²,

Elmadany³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…It has been suggested that synonymous single nucleotide polymorphisms (SNPs), such as C3435T of MDR1 (rs1045642), affect protein expression and function via impaired stability of the mRNA (Sauna et al, 2007); however, this remains to be fully clarified. Several clinical studies have examined whether the C3435T polymorphism is a protective or a risk factor to tumor development, including breast cancer, as well as its effect on clinical outcome and anti-cancer drugs; however, conflicting results have been reported (Sheng et al, 2012;Wang et al, 2012). The aim of this study was to analyze the association of the C3435T polymorphism of MDR1 in Mexican women with either benign fibrocystic changes (FCC) or infiltrating ductal breast cancer (IDBC).…”

Section: Introductionmentioning

confidence: 99%

MDR1 C3435T polymorphism in Mexican patients with breast cancer

et al. 2014

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ABSTRACT. We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro Médico de Occidente (México) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 paraffin-embedded breast samples with IDBC, 64 samples with FCC, and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52% for the FCC, IDBC, and HG samples, respectively. Significant differences were only found between the FCC The prevalence of the T/T genotype was 8, 13, and 24% for FCC, IDBC, and HG samples, respectively. Again, statistical differences were only found between FCC and HG samples for the T/T genotype (OR = 0.28, 95%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the C3435T polymorphism and clinical-pathological features of the IDBC group. Both the FCC and IDBC groups had a high frequency of the C allele relative to the HG in this sample of women from Western Mexico.

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“…However, C3435T polymorphism had no effects on gastrointestinal cancer and lung cancer risk (Sheng et al, 2012). The other meta-analysis from China supported, the C3435T polymorphism might be a risk factor in the susceptibility of breast cancer, renal cancer, and in Caucasian individuals, but it did not show significant role in Asian population and colorectal cancer, gastric cancer, and acute lymphoblastic leukemia (Wang et al, 2012). Lack of association in both studies may be due to ethnic differences or may be related with limited number of patients investigated.…”

Section: Discussionmentioning

confidence: 97%

Is the MDR1 C3435T Polymorphism Responsible for Oral Mucositis in Children with Acute Lymphoblastic Leukemia?

Bektaş-Kayhan¹,

Küçükhüseyin²,

Karagöz³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background and Aim: Although the functional consequences of MDR-1 polymorphisms have been the subject of numerous studies, to the best to our knowledge, associations with clinical side effects of anticancer drugs have yet to be assessed. Our aim was to clarify any role of the C3435T polymorphism of the MDR1 gene in oral mucositis and its relation with elevated reactive oxygen species (ROS) levels, in children with acute lymphoblastic leukemia (ALL). Materials and Methods: The distribution of the MDR-1 C3435T polymorphism in 47 patients with ALL was determined by RFLP and compared with that of 68 healthy controls. Results: There were no association in distribution of genotypes of MDR-1 C3435T polymorphism and the risk of ALL. Oral mucositis were detected in 78.7% (n=37) of the patients and significantly related to the MDR-1 CT genotype (p=0.042), as confirmed by logistic regression analysis. Conclusion: Our preliminary data suggest that children carrying the CT genotype are more prone to develop oral mucositis, which might mean that the heterozygous genotype leads to accumulation of more reactive oxygen species. Since a limited number of patients was investigated, further studies are needed to confirm these findings.

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MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case–control studies

Abstract: In summary, this meta-analysis suggests that the MDR1 C3435T polymorphism is associated with cancer susceptibility, increasing the risk of breast and renal cancer.

Cited by 43 publications

References 48 publications

Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan

Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan

MDR1 C3435T polymorphism in Mexican patients with breast cancer

Is the MDR1 C3435T Polymorphism Responsible for Oral Mucositis in Children with Acute Lymphoblastic Leukemia?

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