MDR1 C3435T polymorphism in Mexican patients with breast cancer

Abstract

ABSTRACT. We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro Médico de Occidente (México) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 paraffin-embedded breast samples with IDBC, 64 samples with FCC, and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52% for the FCC, IDBC, and HG samples, respectively. Significant differences were only found between the FCC The prevalence of the T/T genotype was 8, 13, and 24% for FCC, IDBC, and HG samples, respectively. Again, statistical differences were only found between FCC and HG samples for the T/T genotype (OR = 0.28, 95%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the C3435T polymorphism and clinical-pathological features of the IDBC group. Both the FCC and IDBC groups had a high frequency of the C allele relative to the HG in this sample of women from Western Mexico.

Association between ABCB1 C3435T polymorphism and breast cancer risk: a Moroccan case-control study and meta-analysis

“…In agreement with a number of previous reports [16, 18, 21, 23, 24], our findings revealed no significant association between this polymorphism and breast cancer development. Otherwise, Gutierrez-Rubio et al [24] did not find differences in the distribution of C3435T polymorphism between breast cancer patients and controls.…”

“…In this line, Turgut et al [13], Wu et al [20] and Macías-Gómezdid et al [23] have reported similar results. However, Ghafouri et al have found a significant correlation between ABCB1 C3435T polymorphism and clinical grades of breast cancer with higher grade in CC carriers ( P  = 0.027) [25].…”

Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan

“…Zubor et al (2007), reported that, among patients in Slovak Republic, those carrying CC genotype of C3435T had increased risk of breast cancer. In a study by Macias-Gomez et al (2014) conducted among Mexicans the prevalence of the TT genotype was 8% for patients with fibrocystic changes (FCC), 13% for infiltrating ductal breast cancer (IDBC) and 24% for control samples.…”

ABCB13435TT andABCG2421CC genotypes were significantly associated with longer progression-free survival in Chinese breast cancer patients

“…Other clinicopathological features in this study were not significantly related to ABCB 1 C3435T polymorphisms. Turgut et al [ 36 ], Wu et al [ 9 ] and Macías-Gómezdid et al [ 37 ] reported similar results. The correlation between the clinicopathological features of breast carcinoma in our study, according to ABCG 2 C421A polymorphism revealed no significant association at this level.…”