MDMA (ecstasy) enhances loud noise‐induced morphofunctional alterations in heart and adrenal gland

Fulceri, Federica; Ferrucci, Michela; Lenzi, Paola; Soldani, Paola; Bartalucci, Alessia; Paparelli, Antonio; Gesi, Marco

doi:10.1002/jemt.20971

Cited by 6 publications

(3 citation statements)

References 152 publications

(199 reference statements)

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“…[23] Some studies have assessed the physiological and psychological effects of noise and its relation to quality-of-life. [24,25] The present findings indicate that a prolonged exposure to noise induced structural and functional modifications in the myocardium and adrenal gland.…”

Section: Damaged Myocardial Cells (Masson's Trichrome) (B ×40) Necrmentioning

confidence: 99%

Morphological changes of adrenal gland and heart tissue after varying duration of noise exposure in adult rat

Gannouni¹,

Mhamdi

May

et al. 2014

Noise Health

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Noise was considered an environmental stressor causing a wide range of health effects such as acoustic, cardiovascular, nervous, and endocrine systems. The present study was performed to examine the effects of a repeated noise exposure on adrenal gland and heart tissue. The results showed that exposure to moderate intensity sound (70 dB[A]) causes time-dependent changes in the morphological structure of the adrenal cortex that involve disarrangement of cells and modification in thickness of the different layers of the adrenal gland. The experiment revealed important changes depending on exposure duration in the morphological structure of heart tissue that causes irreversible cell damage leading to cell death or necrosis.

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Section: Damaged Myocardial Cells (Masson's Trichrome) (B ×40) Necrmentioning

confidence: 99%

Morphological changes of adrenal gland and heart tissue after varying duration of noise exposure in adult rat

Gannouni¹,

Mhamdi

May

et al. 2014

Noise Health

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“…Those neurotransmitters have vasoconstrictive and growth modulating effects on smooth muscle cells leading to the development of PAH (Montani et al, 2013). Fulceri and colleagues have also found that the combination of MDMA and loud noise, as in mass recreational activities, can potentiate the effects of prolonged loud noise exposure which might explain the unexpected fatal events that happen in entertainment and rave events (Fulceri et al, 2011). neurological excitation, lethargy, sleep deprivation, heart and blood vessel toxicity, and malnutrition in case of chronic substance misuse (Drug Enforcement Admin, 2003).…”

Section: Amphetamines and Cardiovascular Interactionsmentioning

confidence: 99%

Adverse Effects of Amphetamines on the Cardiovascular System: Review and Retrospective Analyses of Trends

Al-Imam¹

2017

GJHS

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Background: Amphetamine and amphetamine-type stimulants are powerful physical and psychostimulants; they are phenethylamine derivatives. The use of amphetamines can be either medicinal or illicit. Several amphetamines have been redesigned into illegal drugs of potent properties, also known as research chemicals and designer drugs. Hence, they are named novel (new) psychoactive substances (NPS). Materials and Methods:This study is a hybrid study of; data crunching and retrospective analysis of a trends database (1), and a systematic review of literature in relation to the amphetamines-induced adverse effects on the cardiovascular system (2). Google Trends database has been analysed in retrospect (2012)(2013)(2014)(2015)(2016)(2017) to evaluate the attentiveness of surface web users towards amphetamine and a potent renowned amphetamine derivative known as captagon (fenethylline).Results: Amphetamines appear to be highly popular worldwide, particularly in the developed world including North America and European countries, and to a less extent in the developing countries including the Middle East. However, the trends are oscillating with time with significant year-to-year changes although there was some steadiness in the temporal patterns (trends), for example in 2013-2014 (p-value=0.258). Variations in the trends were found to be correlated with global events including international terrorism. The adverse effects of amphetamines were found to be highly related to the cardiovascular system with a high incidence of intoxications and deaths among substance (ab)users. Conclusion:Several amphetamines are potent and used illicitly beyond their original therapeutic potential, as in the case of captagon, culminating in monumental public and economic threats. Legalising bodies should exercise tremendous and systematic efforts to counteract these threats. Database analyses can provide an accurate insight into this phenomenon that has been growing exponentially in the past decade.

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“…Prolonged exposure to noise can lead to excessive stimulation of inner ear hair cells, resulting in structural damage and the consequent attenuation and distortion of incoming auditory stimuli, which is one of the main reasons for hearing loss [ 9 , 10 ]. Noise is also related to cardiovascular disease, and the association can be explained by the biochemical changes related to the mechanisms of stress, in brief, an increase in the level of hormones such as cortisol, adrenaline, and noradrenaline in response to the stress caused by noise can result in peripheral vasoconstriction, increased heart rate, and increased arterial blood pressure (BP) [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional study on the health of workers exposed to occupational noise in China

Jin,

He,

Zhang

et al. 2024

PLoS ONE

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Objective This study aimed to understand the health of workers exposed to occupational noise and explore the influencing factors related to workers’ health, especially the impact of noise on workers’ hearing. This work can provide a basis for formulating relevant measures for occupational noise prevention and control in the future. Methods On the basis of the key occupational disease monitoring project in Chongqing, China, in 2021, the data of 1125 workers exposed to occupational noise were analyzed. Data included demographic information, occupational history, clinical physical examination information, and noise detection information of the working environment. Chi-square test and multifactorial logistic regression were used for statistical analysis. Results The prevalence rates of abnormal electrocardiogram (ECG), blood pressure (BP), and pure tone audiometry (PTA) were 21.9% (246/1125), 27.8% (313/1125), and 18.0% (202/1125), respectively. Male workers accounted for 78.8%. Compared with male workers, female workers had a lower prevalence of abnormal PTA (OR = 0.28, 95% CI = 0.16–0.50). Workers working in medium enterprises had a lower prevalence of abnormal BP than workers in micro enterprises (OR = 0.36, 95% CI = 0.19–0.66). The prevalence of abnormal BP and PTA of workers increased with age. After adjusting for age, sex, and body mass index, the prevalence of abnormal ECG of mining workers was higher than that of manufacturing workers (OR = 1.54, 95% CI = 1.07–2.24), and the prevalence of abnormal PTA had a rising trend with the increase in noise exposure value. Conclusion Noise-exposed workers have a high prevalence of abnormal ECG, BP, and PTA, and factors such as age, enterprise size, and workplace noise exposure are correlated with the aberrant health of workers. Governments, enterprises, and individuals need to attach great importance to the possible adverse effects of noise. They must also actively adopt various effective measures to protect the occupational safety and health of workers.

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MDMA (ecstasy) enhances loud noise‐induced morphofunctional alterations in heart and adrenal gland

Cited by 6 publications

References 152 publications

Morphological changes of adrenal gland and heart tissue after varying duration of noise exposure in adult rat

Morphological changes of adrenal gland and heart tissue after varying duration of noise exposure in adult rat

Adverse Effects of Amphetamines on the Cardiovascular System: Review and Retrospective Analyses of Trends

Cross-sectional study on the health of workers exposed to occupational noise in China

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