MDM2 SNP309 polymorphism is associated with lung cancer risk in women: A meta-analysis using METAGEN

He, Wenwu; Long, Jianxiong; Xian, Lei; Pang, Feng; Su, Li; Wei, Shixiu; Wei, Bo; Hu, Yanling

doi:10.3892/etm.2012.640

Cited by 8 publications

(16 citation statements)

References 39 publications

(64 reference statements)

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“…Recent meta-analyses have also found that SNP309G is associated with increasing lung cancer risk in females but not in males (29,33). However, in the stratified analysis by gender, we did not observe any evidence of their interaction in all the genotype models.…”

Section: Discussioncontrasting

confidence: 46%

Meta-analysis of associations between MDM2 SNP309 polymorphism and gastric cancer risk

Chen

Ren

2013

Biomedical Reports

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Abstract. Epidemiological studies have been conducted to evaluate genetic variations of murine double minute 2 (MDM2) SNP309 associated with the risk of gastric cancer (GC), although evidence remains conflicting. To gain a better understanding of this relationship, a meta-analysis was performed. Several electronic databases were searched up to February 2013, in order to identify relevant case-control studies. Seven published case-control studies with 2,199 cases and 3,201 controls were included. In the overall analysis, significant associations between the MDM2 SNP309 variant and GC risk were found for G vs. T alleles (OR=1.35; 95% CI, 1.24-1.47), GG vs. TT (OR=1.88; 95% CI, 1.59-2.24), recessive model (OR=1.71; 95% CI, 1.49-1.96). Furthermore, stratified by cancer site, significant associations were observed in gastric cardia cancer for all the models, although no significant association was found in any of the models among non-gastric cardia cancer, with the exception of the recessive model. In the subgroup analysis by source of control, MDM2 SNP309 was associated with increased GC risk for the hospital-based case-control (HCC) study for the GG vs. TT, recessive model and for the population-based case-control (PCC) study for the GG vs. TT, recessive model.

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Section: Discussioncontrasting

confidence: 46%

Meta-analysis of associations between MDM2 SNP309 polymorphism and gastric cancer risk

Chen

Ren

2013

Biomedical Reports

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“…The meta-analysis revealed that select ethnic population such as Caucasians and Africans are unaffected by SNP309, while Asians are at considerable risk of lung cancer when carrying SNP309 TG or GG allele (Table 6). These effects are in accordance with the meta-analysis studies published by Zhuo et al [11] and He et al [40].…”

Section: Discussionsupporting

confidence: 92%

A cohort study on the association of MDM2 SNP309 with lung cancer risk in Bangladeshi population

Reza

Anamika

Chowdhury

et al. 2020

Korean J Intern Med

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Background/Aims: Bangladesh is a densely populated country with an increased incidence of lung cancer, mostly due to smoking. Therefore, elucidating the association of mouse double minute 2 homolog (MDM2) single nucleotide polymorphism (SNP) 309 (rs2279744) with lung cancer risk from smoking in Bangladeshi population has become necessary. Methods: DNA was extracted from blood samples of 126 lung cancer patient and 133 healthy controls. The MDM2 SNP309 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), using the restriction enzymes MspA1I. Logistic regression was then carried out to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the risk of lung cancer. A meta-analysis of SNP309 was also carried out on 12,758 control subjects and 11,638 patient subjects. Results: In multivariate logistic regression, significantly increased risk of lung cancer was observed for MDM2 SNP309 in the dominant model (TG + GG vs. TT: OR, 2.13; 95% CI, 1.29 to 3.53). Stratification analysis revealed that age, sex, obesity, and smoking also increases the risk of lung cancer when carrying the MDM2 SNP309. Our meta-analysis revealed that MDM2 SNP309 was considerably associated with lung cancer in Asian populations (TG + GG vs. TT: OR, 1.32; 95% CI , 1.12 to 1.56; p = 0.019 for heterogeneity). Conclusions: The MDM2 SNP309 was associated with high risk of lung cancer in Bangladeshi and Asian population, particularly with increased age, smoking, and body mass index.

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“…The data of the present study suggests that c.309T>G is not associated with the lung cancer risk among the total population, which is in line with numerous epidemiological studies conducted in Caucasians (13,17,18), African-Americans (13) and Asians (14,16,20). A previous meta-analysis study (39) concluded that the association between c.309T>G and lung cancer was statistically significant in Asians, females and never-smokers, but not in Caucasians, males, ever-smokers or among any of the individual histological types.…”

Section: Adjusted or (95% Ci) A -------------------------------------supporting

confidence: 74%

“…A recent meta-analysis study (39) reported that the association between c.309T>G and lung cancer was statistically significant, particularly in the Asian population, female and never-smokers. No statistically significant association was observed in males or ever-smokers.…”

Section: T/t (%) T/g (%) G/g (%) T/t Vs G/g T/t Vs T/g+g/g T/t+t/g mentioning

confidence: 99%

Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk

et al. 2014

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Abstract. Murine double minute 2 (MDM2) is a negative regulator of p53. A single-nucleotide polymorphism (SNP) (rs2279744: c.309T>G) in the promoter region of the MDM2 gene has been shown to result in higher levels of MDM2 RNA and protein. Regarding the contribution of c.309T>G in the MDM2 gene to the lung cancer risk, previous studies are conflicting. In order to evaluate the association between c.309T>G and the lung cancer risk, a case-control study was performed. The MDM2 genotypes were determined in 762 lung cancer patients and in 700 cancer-free control subjects using the Smart Amplification Process. Statistical adjustment was performed for gender, age and pack-years of smoking. The distributions of c.309T>G (T/T, T/G, G/G) were 20.1, 49.7, 30.2% in the case group and 21.7, 47.9, 30.4% in the healthy-control group. There were no overall associations between the MDM2 genotypes and the risk of lung cancer [T/G genotype: Adjusted odds ratio (AOR), 1.30; 95% confidence interval (CI), 0.88-1.93; and G/G genotype: AOR, 1.18; 95% CI, 0.78-1.80]. The subgroup analysis of gender, histology, smoking status and epidermal growth factor receptor mutation status also indicated that there was no association with lung cancer. Additionally, the genotypes did not have an effect on the age at the time of diagnosis of lung cancer (P=0.25). In conclusion, the G allele frequency in the lung cancer cases was 0.551, which was similar to other studies. The results of the present study suggest that the c.309T>G is not significantly associated with lung cancer.

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MDM2 SNP309 polymorphism is associated with lung cancer risk in women: A meta-analysis using METAGEN

Cited by 8 publications

References 39 publications

Meta-analysis of associations between MDM2 SNP309 polymorphism and gastric cancer risk

Meta-analysis of associations between MDM2 SNP309 polymorphism and gastric cancer risk

A cohort study on the association of MDM2 SNP309 with lung cancer risk in Bangladeshi population

Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk

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